Early Evaluation of the Response of Large B Cell Non Hodgkin’s Lymphoma to Chemotherapy by PET/CT
Conditions
Lymphoma, Large-Cell
Conditions: official terms
Lymphoma - Lymphoma, B-Cell - Lymphoma, Non-Hodgkin
Conditions: Keywords
Diffuse large B cells lymphoma, PET/CT, FDG
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Intervention
Name: PET/CT 20 days after the first cycle of chemotherapy
Type: Procedure
Overall Status
Recruiting
Summary
Patients affected with non-Hodgkin’s large B-cell lymphoma are treated by chemotherapy. The evaluation of the response to this treatment is made by Positron Emission Tomography (PET/CT) in many centres where this technology is available. Presently PET scans and CT scans are being performed before treatment, after 4 cycles of chemotherapy and a few months after the end of treatment.

The goal of this study is to determine if it is possible to evaluate the efficiency of chemotherapy treatments after one cycle of treatment instead of waiting after 4 cycles, using a new scanner that combines PET and CT modalities. Data available from studies on these combined exams suggest that PET/CT helps to rapidly evaluate the response of the chemotherapy treatment. We also want to verify if some pathological characteristics measured from tumor cells will enable doctors to predict in advance the response to treatment.
Detailed Description
Participation in this study involves 4 PET/CT exams, which occur before the treatments start, after the first cycle of chemotherapy, after 4 cycles of chemotherapy and then 12 weeks after the end of the treatments. The only additional test performed in this study compared to the regular follow-up of patients that are not in this study is the PET/CT exam after the first cycle. Your participation in this study will not affect treatment since the results of the first PET/CT test will not be communicated. All other tests results will be available in the medical record.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 70 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Newly diagnosed large B cells non Hodgkin’s lymphoma, CD20 positive

- Chemotherapy treatments planned (R-CHOP) but not started

Exclusion Criteria:

- Pregnancy (determined by urinary β-HCG and blood test)

- Patients younger than 18 years

- Unable to tolerate the procedure (30 minutes laying down on the back)

- No chemotherapy treatment planned secondary to the patient's health performance

- Previous lymphoma that has been treated with chemotherapy with the exception of stade I lymphoma treated only with radiotherapy.

- All lymphoma other than large cell Non Hodgkin’s lymphoma
Location
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
Status: Recruiting
Contact: Eric Turcotte, MD, FRCPC - 819-346-1110 - e.turcotte@usherbrooke.ca
Start Date
November 2005
Completion Date
November 2009
Sponsors
Université de Sherbrooke
Source
Université de Sherbrooke
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page