Metabolomic Analysis of Lung Cancer
Conditions
Carcinoma, Non-Small Cell Lung - Carcinoma, Small Cell Lung
Conditions: official terms
Carcinoma - Carcinoma, Non-Small-Cell Lung - Carcinoma, Small Cell - Small Cell Lung Carcinoma
Conditions: Keywords
lung cancer, non-small cell lung cancer, small cell lung cancer, cancer metabolism
Study Type
Observational
Study Phase
Phase 1
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Intervention
Name: 13-C-glucose
Type: Other
Overall Status
Recruiting
Summary
The purpose of this study is to learn more about the metabolic properties of lung cancer cells.
Detailed Description
It has long been known that cancer cells absorb and break down substances in the body differently than healthy, non-cancer cells. This process of absorbing and breaking down substances is known as metabolism and is increased in cancer cells. Recent research suggests that this increased metabolic activity makes it easier for cancer cells to multiply. The objective of the study is to characterize the metabolism of glucose by lung tumors by serum metabolite analysis, using a variant of glucose (sugar) which makes up 1% of glucose in nature.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 75 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Lung Cancer Patients (Groups 1 & 2)

Inclusion Criteria:

- patients with suspected, clinically diagnosed, or histologically diagnosed lung cancer. Occasionally, other cancers (including metastatic cancers to the lung) may be resected for the study as negative controls for NSCLC, as warranted by the particulars of the case.

- patients must have general medical conditions to allow them to undergo surgical resection of their primary tumor

Exclusion Criteria:

- history of diabetes for the experimental group (surgery + glucose); patients with a history of diabetes are allowed in the control group (surgery/no glucose)

- known hepatitis C or HIV (AIDS)

Healthy Subjects (Group 3)

Inclusion Criteria:

- at least 30 years of age

- preferably be fasting for 12 hours (minimum 8 hours) prior to enrollment

Exclusion Criteria:

- prior history of diagnosed lung cancer

- known hepatitis C or HIV (AIDS)
Location
James Graham Brown Cancer Center, University of Louisville
Louisville, Kentucky, United States
Status: Recruiting
Start Date
December 2005
Completion Date
December 2016
Sponsors
James Graham Brown Cancer Center
Source
James Graham Brown Cancer Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page