Familial Barrett's Esophagus
Conditions
Barrett's Esophagus - Esophageal Neoplasm
Conditions: official terms
Barrett Esophagus - Esophageal Neoplasms
Conditions: Keywords
Barrett's Esophagus
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Family-Based, Time Perspective: Cross-Sectional
Overall Status
Recruiting
Summary
This is a multi-center study whose aim is to define the epidemiology and genetics of Barrett's esophagus and adenocarcinoma. The researchers have studied families affected with Barrett's esophagus and esophageal adenocarcinoma, a specific type of cancer of the esophagus. They have found that Barrett's and esophageal cancer occur at a younger age in these families suggesting that familial Barrett's esophagus is a genetically inherited disease.
Detailed Description
This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland and the Cleveland Clinic are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Eligible cases will be defined as those patients and their family members who meet the following criteria:

- Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.

- Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.

- Ability to give informed consent, if patient is age 18 or older.
Locations
Johns Hopkins Hospital
Baltimore, Maryland, United States
Status: Recruiting
Contact: Marcia Canto, M.D. - 410-614-5388
Mayo Clinic
Rochester, Minnesota, United States
Status: Recruiting
Contact: Ganapathy A Prasad, M.D. - 507-255-6930 - Prasad.Ganapathy@Mayo.edu
Washington University School of Medicine
St Louis, Missouri, United States
Status: Recruiting
Contact: Jean Wang, MD - 314-362-5952 - jwang@DOM.wustl.edu
Creighton University Medical Center
Omaha, Nebraska, United States
Status: Recruiting
Contact: Sumeet Mittal, MD - 402-280-4161 - SumeetMittal@creighton.edu
Columbia University Medical Center
New York, New York, United States
Status: Recruiting
Contact: Julian Abrams, MD - 212-342-0476 - ja660@mail.cumc.columbia.edu
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Status: Recruiting
Contact: Nicholas J Shaheen, M.D. - 919-966-2513 - nshaheen@med.unc.edu
Northeastern Ohio University College of Medicine, Mercy Medical Center
Canton, Ohio, United States
Status: Recruiting
Contact: James King, MD - 330-305-2020 - jfjk@aol.com
Cleveland Veterans Administration Medical Center - Wade Park
Cleveland, Ohio, United States
Status: Recruiting
Contact: Margaret Kinnard, MD - 216-791-3800 - Margaret.kinnard@med.va.gov
The Cleveland Clinic
Cleveland, Ohio, United States
Status: Recruiting
Contact: John Vargo, MD - 216-444-1000 - jvargo@ccf.org
University Hospitals of Cleveland
Cleveland, Ohio, United States
Status: Recruiting
Contact: Amitabh Chak, MD - 216-844-5386 - axc22@po.cwru.edu
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Gary W Falk, MD, MS - 215-615-6588 - Gary.Falk@uphs.upenn.edu
Fred Hutchinson Cancer Research Center, UWMC
Seattle, Washington, United States
Status: Recruiting
Contact: William Grady, MD - 206-667-1107 - wgrady@fhcrc.org
Start Date
October 2005
Completion Date
September 2017
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Source
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page