Feasibility of Radiofrequency Ablation in the Management of Papillary Thyroid Cancer Under Ultra-Sound Guidance.
Conditions
Papillary Thyroid Cancer
Conditions: official terms
Carcinoma - Thyroid Diseases - Thyroid Neoplasms
Conditions: Keywords
radio-frequency, ablation, ultra-sound, guidance, papillary, thyroid, cancer
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Ultra-sound guided radio-frequency ablation
Type: Procedure
Overall Status
Not yet recruiting
Summary
To study the feasibility of Radiofrequency ablation (RFA) via ultrasound guidance in the treatment of papillary thyroid cancer (PTC).
Detailed Description
Around 23,000 cases of thyroid cancer are discovered annually in the US, and PTC accounts for 70-75% of those cases. The conventional treatment consists mainly of surgical resection, in the form of lobectomy with/without isthmusectomy, or total thyroidectomy, making it one of the most commonly performed procedures. It has high costs, and exposes the patients to morbidity of surgery and anesthesia. PTC tends to be indolent with a 90% cure rate and controversy exists regarding extent of treatment.

Percutaneous image-guided RFA has received increasing attention as a promising minimally invasive technique for the treatment of focal malignant disease. It permits the in situ destruction of tumors without necessitating their surgical excision.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 90 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Aged 18-90 years old

- Patients with low risk well-differentiated PTC, diagnosed by US guided FNA, and whose management decision is total thyroidectomy.

- Patients with only one dominant malignant nodule will be included in the study.

- Patients with size of their thyroid nodule ranging only between 1-4cm in diameter will be included in the study.

- Patients with nodules located only in between the mid and lower pole of the thyroid gland will be included in the study.

Exclusion Criteria:

- When the patient does not meet the inclusion criteria.

- When the patient has a contra-indication of surgery or anesthesia.

- If the patient refuses involvement in the study.
Location
Johns Hopkins University, School of Medicine
Baltimore, Maryland, United States
Status: Not yet recruiting
Start Date
November 2006
Completion Date
November 2008
Sponsors
Johns Hopkins University
Source
Johns Hopkins University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page