Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Colonic Neoplasms
Conditions: official terms
Colonic Neoplasms - Colorectal Neoplasms
Conditions: Keywords
Colonic Neoplasms, Lynch syndrome
Study Type
Study Phase
Study Design
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
Overall Status
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
Detailed Description
Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- Colorectal cancer

Exclusion Criteria:

- Histology showing other than adenocarcinoma
Samsung Medical Center
Seoul, Gangnam-gu, Korea, Republic of
Status: Recruiting
Contact: Tae Kyun Kim - +82-2-3410-2975 -
Start Date
January 2006
Completion Date
December 2011
Samsung Medical Center
Samsung Medical Center
Record processing date processed this data on July 28, 2015 page