Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease
Conditions
Chronic Liver Disease - Hepatocellular Carcinoma
Conditions: official terms
Carcinoma, Hepatocellular - Liver Diseases
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Intervention
Name: TNF-alpha and HBV genotype Type: Genetic
Name: TNF-alpha and HBV genotypes Type: Other
Overall Status
Recruiting
Summary
The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- HBV-positive patients

Exclusion Criteria:

- HBV-negative patients
Location
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan
Status: Recruiting
Contact: Jen-Eing Jeng, M.D. - 886-7-3121101 - jejeng @cc.kmu.edu.tw
Start Date
January 2007
Completion Date
December 2007
Sponsors
Kaohsiung Medical University Chung-Ho Memorial Hospital
Source
Kaohsiung Medical University Chung-Ho Memorial Hospital
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page