Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease
Chronic Liver Disease - Hepatocellular Carcinoma
Conditions: official terms
Carcinoma, Hepatocellular - Liver Diseases
Study Type
Study Phase
Study Design
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Name: TNF-alpha and HBV genotype Type: Genetic
Name: TNF-alpha and HBV genotypes Type: Other
Overall Status
The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- HBV-positive patients

Exclusion Criteria:

- HBV-negative patients
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan
Status: Recruiting
Contact: Jen-Eing Jeng, M.D. - 886-7-3121101 - jejeng
Start Date
January 2007
Completion Date
December 2007
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung Medical University Chung-Ho Memorial Hospital
Record processing date processed this data on July 28, 2015 page