Study of Genes and Environment in Patients With Breast Cancer in the East Anglia Region of the United Kingdom
Conditions
Breast Cancer
Conditions: official terms
Breast Neoplasms
Conditions: Keywords
breast cancer, male breast cancer
Study Type
Observational
Study Phase
N/A
Study Design
N/A
Intervention
Name: polymorphism analysis Type: Genetic
Name: laboratory biomarker analysis Type: Other
Name: questionnaire administration Type: Other
Overall Status
Recruiting
Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with breast cancer.
Detailed Description
OBJECTIVES:

- To obtain epidemiological information and biological material on a population-based series of breast cancer cases.

- To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of breast cancer by comparing the frequency of alterations in breast cancer patients with the corresponding frequency in controls.

- To define the proportion of breast cancer incidence attributable to mutations in such genes.

- To examine the interactions between genetic and nongenetic risk factors.

- To evaluate the relationship between pathological and clinical characteristics of breast cancers and germline genotype.

OUTLINE: This is a multicenter study.

Patients complete an epidemiological questionnaire that covers standard known breast cancer risk factors including reproductive history, oral contraceptive use, hormone replacement therapy use, family history, and alcohol consumption. The questionnaire will also request identifying information on the patient's first-degree relatives.

Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.

In addition to the breast cancer patients recruited for this study, patients with malignant melanoma and lymphoma, colorectal, ovarian, prostate, colorectal, bladder, kidney, pancreatic, and esophageal cancer, and brain tumors are recruited for the following related clinical trials: MREC-SEARCH-COLORECTAL, MREC-SEARCH-OVARIAN, MREC-SEARCH-PROSTATE, MREC-SEARCH-ENDOMETRIAL, and MREC-SEARCH-CANCER.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 70 Years
Minimum Age: 18 Years
Gender: Both
Criteria: DISEASE CHARACTERISTICS:

- Diagnosis of breast cancer within the past 5 years

- Identified through the East Anglian Cancer Registry in the East Anglia region of the United Kingdom

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- Identified by the patient's general practitioner as fit to contact for this study

- No serious mental illness or retardation

PRIOR CONCURRENT THERAPY:

- Not specified
Location
University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
Status: Recruiting
Contact: Contact Person - 44-122-374-0166 - paul.pharoah@srl.cam.ac.uk
Start Date
February 2008
Sponsors
Cancer Research UK
Source
National Cancer Institute (NCI)
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page