Autoantibody Blood Test in Finding Metastasis in Patients With Localized or Metastatic Kidney Cancer
Conditions
Kidney Cancer
Conditions: official terms
Carcinoma, Renal Cell - Kidney Neoplasms
Conditions: Keywords
stage I renal cell cancer, stage II renal cell cancer, stage III renal cell cancer, stage IV renal cell cancer
Study Type
Interventional
Study Phase
N/A
Study Design
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Intervention
Name: gene expression analysis Type: Genetic
Name: protein expression analysis Type: Genetic
Name: diagnostic laboratory biomarker analysis Type: Other
Name: immunoenzyme technique Type: Other
Name: immunohistochemistry staining method Type: Other
Overall Status
Recruiting
Summary
RATIONALE: Studying specific autoantibodies in blood samples from patients with cancer may help doctors find metastasis and help plan cancer treatment.

PURPOSE: This clinical trial is studying an autoantibody blood test in finding metastasis in patients with localized or metastatic kidney cancer.
Detailed Description
OBJECTIVES:

- To develop an anti-IMP3 autoantibody blood test to identify the status of current and potential metastasis in patients with localized or metastatic renal cell carcinoma.

OUTLINE: Serum samples obtained prior to surgery are analyzed for anti-IMP3 autoantibody by ELISA. Tissue samples obtained at the time of surgery are examined for IMP3 gene overexpression by IHC. The results of the ELISA serum assay are then compared with the results of the IHC tissue analysis to evaluate the sensitivity and specificity of the assay.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: DISEASE CHARACTERISTICS:

- Diagnosis of renal cell carcinoma (RCC)

- Localized or metastatic disease

- Undergoing surgery at the City of Hope National Medical Center to remove primary and/or metastatic lesions

- Serum and tissue samples available, including any of the following:

- Discarded or left-over plasma/serum samples from the Blood Bank of the Department of Transfusional Medicine

- Formalin-fixed paraffin-embedded (FFPE) and/or frozen primary and/or metastatic RCC tissue samples

- FFPE and/or frozen benign renal tissue samples that are near the tumor and removed during surgery

- Discarded or leftover FFPE and/or frozen renal tissue samples from the Department of Anatomic Pathology and its Tumor Bank

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics
Location
City of Hope Medical Center
Duarte, California, United States
Status: Recruiting
Contact: City of Hope Medical Center - 800-826-4673
Start Date
June 2008
Sponsors
City of Hope Medical Center
Source
City of Hope Medical Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page