Genetic Susceptibility to Bladder Cancer
Bladder Cancer - Healthy
Conditions: official terms
Disease Susceptibility - Genetic Predisposition to Disease - Urinary Bladder Neoplasms
Conditions: Keywords
Bladder cancer, Genetic susceptibility, Increased Risk
Study Type
Study Phase
Study Design
Time Perspective: Prospective
Name: Specimens, personal and follow-up telephone interviews
Type: Other
Overall Status
Bladder cancer (BC) is a model disease system for evaluating the relationship of tobacco, dietary, and occupational exposures (which are responsible for up to 90% of BCs) and host-specific susceptibility factors. The induction of BC by arylamines (from tobacco or occupational exposure) is one of the best understood types of carcinogenesis. There is also substantial evidence suggesting that an individual's genetic make-up influences susceptibility to cancer.

This clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer. We propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- Subject has a histologically confirmed diagnosis of superficial or muscle-invasive bladder cancer

- Subject is a Texas resident.

- Subject can understand English or a qualified translator is available for the interview.

- Subjects of any age, gender, or ethnicity are eligible to participate in the study.

- Subject consents to participate in the study.

Exclusion Criteria:

- Subject has had prior treatment with systemic chemotherapy or radiotherapy in the past 6 months.

- Subject has been diagnosed with superficial or muscle-invasive bladder cancer more than twelve months ago.
Baylor College of Medicine
Houston, Texas, United States
Status: Recruiting
Contact: Susan L. Kingston, LVN, CCRP - 713-798-8514 -
M.D. Anderson Cancer Center
Houston, Texas, United States
Status: Recruiting
Contact: XIFENG WU, MD - 713-792-0807 -
Start Date
July 2008
Completion Date
January 2014
Baylor College of Medicine
Baylor College of Medicine
Record processing date processed this data on July 28, 2015 page