Level of HER2-neu Gene Amplification an Response to Trastuzumab
Conditions
Advanced Breast Cancer
Conditions: official terms
Breast Neoplasms
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Retrospective
Intervention
Name: Fluorescent in-situ hybridization (FISH)
Type: Genetic
Overall Status
Recruiting
Summary
Primary objective of the study is to evaluate the correlation between level of HER2-neu gene amplification evalued by dual-color Fluorescent in-situ hybridization (FISH) test and time to progression (TTP) in patients with HER2-positive advanced breast cancer treated with trastuzumab-containing regimens.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- HER2-positive breast cancer Trastuzumab-containing regimen delivered for advanced disease Tumor sample available at Pathology Archive

Exclusion Criteria:

- HER2-negative advanced breast cancer Pretreatment with trastuzumab
Location
Istituto Clinco Humanitas
Rozzano, Milan, Italy
Status: Recruiting
Contact: Armando Santoro, MD - +39028224 - armando.santoro@humanitas.it
Start Date
March 2009
Completion Date
December 2009
Sponsors
Istituto Clinico Humanitas
Source
Istituto Clinico Humanitas
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page