Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer
Conditions
Lung Cancer
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
stage I non-small cell lung cancer, stage II non-small cell lung cancer
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Intervention
Name: gene expression analysis Type: Genetic
Name: microarray analysis Type: Genetic
Name: protein expression analysis Type: Genetic
Name: biologic sample preservation procedure Type: Other
Name: laboratory biomarker analysis Type: Other
Name: matrix-assisted laser desorption/ionization time of flight mass spectrometry Type: Other
Overall Status
Recruiting
Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer.

PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.
Detailed Description
OBJECTIVES:

- Develop statistical and computational methods for modeling the relationships between multiple variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches.

- Determine protein and RNA expression fingerprints on completely resected non-small cell lung cancer without prior chemotherapy.

- Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at the time of surgery, and collect outcome data to allow correlation with recurrence (local and/or distant) and survival.

OUTLINE: This is a multicenter study.

Any excess tissues removed from surgery and would otherwise be discarded (tissues not used for diagnosis and/or treatment decision making) are obtained for this study. Tissue are analyzed for molecular features that predict biologic behavior. Quantitation of RNA, gene expression profiles, and protein expression patterns are assessed by matrix-assisted laser desorption/ionization time of flight mass spectroscopy and microarray analysis.

Medical records are reviewed to obtain information about results of tests associated with cancer diagnosis. Further progress in cancer treatment and tumor behavior after surgery are followed via record review.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion criteria

- Diagnosis of non-small cell lung cancer

- Clinical stage I and II disease

- Resectable disease and complete surgical resection planned

- Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network

- Tumor specimen samples must be available at resection

Exclusion criteria

- Chemotherapy before surgery

- Radiotherapy before surgery
Locations
Dan Rudy Cancer Center at Saint Thomas Hospital
Nashville, Tennessee, United States
Status: Recruiting
Contact: Contact Person - 615-222-2166
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Status: Recruiting
Contact: Clinical Trials Office - Vanderbilt-Ingram Cancer Center - 800-811-8480
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States
Status: Recruiting
Contact: Clinical Trials Information Program - 800-811-8480
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States
Status: Recruiting
Contact: Clinical Trials Information Program - 800-811-8480
Veterans Affairs Medical Center - Nashville
Nashville, Tennessee, United States
Status: Recruiting
Contact: Clinical Trials Office - Veterans Affairs Medical Center - Nas - 615-327-4751
Start Date
May 2001
Completion Date
July 2017
Sponsors
Vanderbilt-Ingram Cancer Center
Source
Vanderbilt-Ingram Cancer Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page