Hypofractionated Intensity Modulated Chemoradiotherapy to Treat Locally Advanced Non-Small Cell Lung Cancer
Conditions
Stage III Non-Small Cell Lung Cancer
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Study Type
Interventional
Study Phase
Phase 2
Study Design
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Dose escalated, accelerated, hypofractionated radiotherapy
Type: Radiation
Overall Status
Recruiting
Summary
Locally advanced non-small cell lung cancer can be treated successfully with chemotherapy and radiation. However, the cure rate is low.

This study is carried out to find out whether giving radiotherapy at a higher dose over fewer treatment sessions with intensity modulated radiotherapy (IMRT) can improve the treatment outcome.

This study aims to recruit 43 patients from National University Hospital and Tan Tock Seng Hospital over a period of about 2 years.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 70 Years
Minimum Age: 21 Years
Gender: Both
Criteria: Inclusion Criteria:

- Pathologically proven (either histologic or cytologic) diagnosis of Stage IIIA or IIIB non-small cell lung cancer; excluding patients with N3 disease based on supraclavicular or contralateral hilar adenopathy, or significant pleural / pericardial effusion.

Exclusion Criteria:

- Patients for whom treatment is planned with a maximum dose of ≥ 66 Gy to the ipsilateral brachial plexus

- Greater than minimal, exudative, or cytologically positive pleural effusions

- ≥ 10% weight loss within the past month

- Prior invasive malignancy (with exceptions)

- Prior radiotherapy to the region of the study cancer

- Significant co-morbidities

- Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception

- Known allergic reactions to components of planned chemotherapy regimen
Locations
National University Hospital
Singapore, Singapore
Status: Recruiting
National University Hospital
Singapore, Singapore
Status: Recruiting
Contact: Jay Lu, MD - 6567724870
Tan Tock Seng Hospital
Singapore, Singapore
Status: Recruiting
Contact: Cheng Nang Leong, MD - 6563571070
Start Date
July 2009
Sponsors
National University Hospital, Singapore
Source
National University Hospital, Singapore
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page