Genetic and Environmental Risk Factors Related to Esophageal Cancer
Conditions
Esophageal Cancer
Conditions: official terms
Esophageal Neoplasms
Conditions: Keywords
stage 0 esophageal cancer, stage I esophageal cancer, stage II esophageal cancer, stage III esophageal cancer, stage IV esophageal cancer
Study Type
Observational
Study Phase
N/A
Study Design
N/A
Intervention
Name: DNA analysis Type: Genetic
Name: polymorphism analysis Type: Genetic
Name: questionnaire administration Type: Other
Overall Status
Recruiting
Summary
RATIONALE: Gathering information about genes, cigarette smoking, and diet may help doctors learn more about risk factors that may cause esophageal cancer.

PURPOSE: This clinical trial is studying genetic and environmental risk factors related to esophageal cancer.
Detailed Description
OBJECTIVES:

- Examine the role of several genetically-determined factors in combination with cigarette smoking and diet in the etiology and prevention of esophageal cancer.

- Identify polymorphisms in metabolizing enzymes (e.g., phase I or II metabolism [GSTM1, GSTT1,CYP1A1, CYP3A5, mEH, NQO1, GSTP1], DNA repair [XRCC1, ERCC2], free-radical formation [MPO, MnSOD], inflammatory genes [ IL1-beta], metastatic potential [MMP1], and cell cycle or tumor suppression [p21, p53]) and related path genes of susceptibility for esophageal cancer.

OUTLINE: Blood and tumor tissue samples are collected. DNA purified from these samples is analyzed using DNA-based assays to determine polymorphisms in various related gene pathways.

Patients complete questionnaires concerning environmental, smoking and diet habits.

PROJECTED ACCRUAL: A total of 1,000 tissue samples from patients and healthy participants (750 patients and 250 healthy participants) will be accrued for this study.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Diagnosis of esophageal cancer (patient)

- Newly diagnosed disease

- Receiving care at Massachusetts General Hospital, Thoracic Oncology Center

- Friend or spouse of patient (healthy participants)

PATIENT CHARACTERISTICS:

- No concurrent psychiatric incapacity or dementia

PRIOR CONCURRENT THERAPY:

- Not specified
Locations
Harvard School of Public Health
Boston, Massachusetts, United States
Status: Recruiting
Contact: David C. Christiani, MD - 617-726-9274
Massachusetts General Hospital
Boston, Massachusetts, United States
Status: Recruiting
Contact: Clinical Trials Office - Massachusetts General Hospital - 877-726-5130
Sponsors
Massachusetts General Hospital
Source
National Cancer Institute (NCI)
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page