Partial Liver Radiotherapy for Unresectable Liver Metastases
Conditions
Metastatic Colorectal Liver Cancer
Conditions: official terms
Liver Neoplasms
Conditions: Keywords
colorectal liver cancer, metastatic, radiation therapy
Study Type
Interventional
Study Phase
N/A
Study Design
Primary Purpose: Treatment
Intervention
Name: radiation therapy
Type: Radiation
Overall Status
Recruiting
Summary
This study is designed to treat tumors in the liver that cannot be removed surgically and chemotherapy cannot control these tumors, using radiation therapy and a more precise delivery than has been used before.
Detailed Description
The purpose of this study is to evaluate safety and feasibility of conformal radiation therapy in patients with metastatic colorectal liver cancer. This study would also evaluate local control rate within irradiated area and to assess failure patterns and survival of patients treated with conformal liver radiation.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- liver metastases unequivocally seen on contrast enhanced CT and/or MRI from colon or rectal cancer, previously confirmed pathologically as adenocarcinoma

- either 1) the tumor must be unresectable, 2) the patient must be medically inoperable, or 3) extra-hepatic metastases are present (making hepatic surgery an inappropriate treatment option)

- good performance status (0-1)

- Age > 18 years. Adult patients of all ages, both sexes and all races will be included in this study. Female patients within reproductive years may not be, nor become, pregnant during participation in this study

- life expectancy > 3 months

Exclusion Criteria:

- patients with active hepatitis or clinically significant liver failure

- patients receiving anticoagulation treatment with warfarin or heparin

- prior radiation therapy to the right upper abdomen, precluding re-irradiation of the liver

- clinically apparent ascites

- central nervous system metastases
Location
Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom
Status: Recruiting
Contact: Maria Hawkins - 020 8661 8915
Start Date
November 2006
Completion Date
June 2008
Sponsors
Royal Marsden NHS Foundation Trust
Source
Royal Marsden NHS Foundation Trust
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page