A Comprehensive Study to Isolate Tumor-initiating Cells From Human Epithelial Malignancies
Conditions
Bladder Cancer - Skin Cancers - Bladder (Urothelial, Transitional Cell) Cancer - Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy)
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Not yet recruiting
Summary
We hypothesize that all human malignancies harbour a subpopulation of tumor initiating cells/cancer stem cells (CSCs) that drives tumor development and potentially recurrence or metastasis of the disease. The primary aim of this study is to develop strategies for prospective isolation/enrichment of CSCs from human tumors of different tissue origins. In addition, we will characterize the signaling pathways and/or tumor specific antigens that are specific for CSCs, in order to specifically target these CSCs as the endpoint of this study.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:N/A. We will recruit all non-melanoma skin and bladder cancer patients that are recommended for surgical removal of tumor tissues. This includes patients from all ages, gender and ethnicity background. Our sample collection criteria based on the tumor size of individual (e.g. tumor samples will only be collected if it will not affect the pathological diagnosis or treatment procedures of patients).

Exclusion Criteria:N/A
Location
Stanford University School of Medicine
Stanford, California, United States
Status: Not yet recruiting
Contact: Linda Quinn - 650-723-6520 - ljquinn@stanford.edu
Start Date
December 2013
Completion Date
December 2014
Sponsors
Stanford University
Source
Stanford University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page