Efficacy of Ultrasound Contrast Agent to Assess Renal Masses
Renal Cell Carcinoma
Conditions: official terms
Carcinoma - Carcinoma, Renal Cell
Conditions: Keywords
Small renal Mass, Contrast Enhanced Ultrasound, Renal Cell Carcinoma, noninvasive diagnosis of RCC
Study Type
Study Phase
Phase 2
Study Design
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Name: Definity
Type: Drug
Overall Status
Patients with an incidentally discovered small renal masses (SRM) < 4 cm in diameter are included. All patients will undergo biopsy for tissue diagnosis. Most patients will be followed by imaging. Study intervention includes low MI US to be performed following both bolus and infusion injection of Definity contrast. Presence and absence of vascularity, pattern of vascularity, and TIC values will be correlated with the final pathology to find features differentiating benign from malignant masses.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

- Patients with newly diagnosed Renal mass < 4 cmm, who are going to undergo diagnostic CT, MRI or biopsy.
Toronto General Hospital
Toronto, Ontario, Canada
Status: Recruiting
Contact: mostafa atri, MD - 416 340 4800 - mostafa.atri@uhn.on.ca
Start Date
October 2009
University Health Network, Toronto
University Health Network, Toronto
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page