Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma
Conditions
Advanced Malignant Mesothelioma - Epithelioid Mesothelioma - Recurrent Malignant Mesothelioma - Sarcomatoid Mesothelioma
Conditions: official terms
Lung Neoplasms - Mesothelioma
Study Type
Interventional
Study Phase
Phase 1/Phase 2
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Cediranib Maleate Type: Drug
Name: Cisplatin Type: Drug
Name: Pemetrexed Disodium Type: Drug
Name: Placebo Type: Other
Overall Status
Recruiting
Summary
This randomized phase I/II trial is studying the side effects and best dose of cediranib maleate when given together with pemetrexed disodium and cisplatin and to see how well it works in treating patients with malignant pleural mesothelioma. Drugs used in chemotherapy, pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving pemetrexed disodium and cisplatin together with cediranib maleate may kill more tumor cells.
Detailed Description
OBJECTIVES:

I. To establish the maximum tolerated dose and the recommended phase II dose of cediranib maleate in combination with pemetrexed disodium and cisplatin in patients with malignant pleural mesothelioma. (Phase I) II. To compare the progression-free survival of patients treated with pemetrexed disodium and cisplatin with vs without cediranib maleate. (Phase II) III. To compare the overall survival of patients treated with these regimens. (Phase II) IV. To assess the safety and toxicity profile of these regimens. V. To assess the response rate (confirmed and unconfirmed, complete and partial responses) and disease control rate (responsive or stable disease) using RECIST criteria and modified RECIST criteria for pleural tumors in a subset of patients with measurable disease. (Phase II) VI. To assess the rate of agreement between local and central pathology review of mesothelioma and its histologic subtypes. (Phase II) VII. To collect specimens for banking for use in future research studies. (Phase II)

OUTLINE: This is a multicenter, phase I dose-escalation study of cediranib maleate followed by a phase II randomized study. Patients enrolled in the phase II portion of the study are stratified according to Zubrod performance status (0-1 vs 2) and histologic subtype (epithelioid vs biphasic/sarcomatoid).

PHASE I: Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 2 hours on day 1 and oral cediranib maleate once daily on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive oral cediranib maleate alone once daily in the absence of disease progression or unacceptable toxicity.

PHASE II: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 2 hours on day 1 and oral cediranib maleate once daily at the maximum tolerated dose determined in phase I on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive oral cediranib maleate alone once daily in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive pemetrexed disodium and cisplatin as in arm I and oral placebo once daily on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive oral placebo alone once daily in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for up to 3 years.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically or cytologically confirmed malignant pleural mesothelioma

- Not planning to undergo surgical resection

- Patients must have measurable or non-measurable disease by both RECIST and modified RECIST criteria for pleural tumors as documented by CT scan; examinations for assessment of measurable disease must have been completed within 28 days prior to registration; examinations for assessment of non-measurable disease must have been performed within 42 days prior to registration; all disease must be assessed and documented on the RECIST 1.1 and Modified RECIST Baseline Tumor Assessment Form

- Zubrod performance status 0-2

- ANC ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin ≥ 9.0 g/dL (transfusion allowed)

- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

- SGOT or SGPT ≤ 2.5 times ULN (≤ 5 times ULN if liver metastases are present)

- Serum creatinine ≤ 1.5 times ULN

- Creatinine clearance ≥ 60 mL/min

- Proteinuria ≤ +1 on 2 consecutive dipsticks taken ≥ 7 days apart

- Repeat urinalysis not required provided first urinalysis shows no protein

- Not pregnant or nursing

- Fertile patients must agree to use effective contraception

- Must be able to swallow oral medications

- No mean QTc > 500 msec (with Bazett correction) by ECG or other significant ECG abnormality

- No NYHA class III-IV congestive heart failure

- No clinically significant hemoptysis, defined as > 1 tablespoon of bright red blood, within the past year

- No known HIV infection

- No other malignancy within the past 5 years except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or adequately treated stage I or II cancer from which the patient is currently in complete remission.

- No other concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy or any other type of therapy for treatment of cancer

- No prior systemic therapy (chemotherapy or other biological therapy) for unresectable malignant pleural mesothelioma

- Prior systemicchemotherapy or biologic therapy as neoadjuvant or adjuvant therapy allowed provided disease has recurred and systemic therapy was completed > 6 months before study entry

- No prior therapy with any of the study drugs

- At least 28 days since prior surgery (e.g., pleurectomy, pleurodeses, thoracic or other major surgeries) and recovered

- At least 28 days since prior radiotherapy and recovered

- No concurrent medication that may markedly affect renal function (e.g., vancomycin, amphotericin, pentamidine)

- No concurrent drugs or biologics with proarrhythmic potential

- No concurrent major surgery
Locations
Highlands Oncology Group-Rogers
Rogers, Arkansas, United States
Status: Recruiting
Contact: Joseph T. Beck - 800-381-6939
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, United States
Status: Recruiting
Contact: Keith S. Lanier - 503-215-6412
Kaiser Permanente-Fremont
Fremont, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente
Fresno, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Los Angeles County-USC Medical Center
Los Angeles, California, United States
Status: Recruiting
Contact: Barbara J. Gitlitz - 323-865-0451
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Status: Recruiting
Contact: Barbara J. Gitlitz - 323-865-0451
Kaiser Permanente-Modesto
Modesto, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Oakland
Oakland, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, United States
Status: Recruiting
Contact: Sai-Hong I. Ou - 877-827-8839 - ucstudy@uci.edu
Kaiser Permanente-Redwood City
Redwood City, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Richmond
Richmond, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Roseville
Roseville, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente - Sacramento
Sacramento, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-South Sacramento
Sacramento, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Status: Recruiting
Contact: Karen L. Kelly - 916-734-3089
Kaiser Permanente-San Francisco
San Francisco, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente San Leandro
San Leandro, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-San Rafael
San Rafael, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-South San Francisco
South San Francisco, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Stockton
Stockton, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Vallejo
Vallejo, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
UF Cancer Center at Orlando Health
Orlando, Florida, United States
Status: Recruiting
Contact: Tirrell T. Johnson - 321-841-7246 - CancerClinicalTrials@orlandohealth.com
Northeast Georgia Medical Center
Gainesville, Georgia, United States
Status: Terminated
Oncare Hawaii Inc-Pali Momi
Aiea, Hawaii, United States
Status: Withdrawn
Pali Momi Medical Center
Aiea, Hawaii, United States
Status: Withdrawn
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, United States
Status: Recruiting
Contact: Louis Fehrenbacher - 626-564-3455
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States
Status: Withdrawn
Kuakini Medical Center
Honolulu, Hawaii, United States
Status: Withdrawn
Oncare Hawaii Inc-Kuakini
Honolulu, Hawaii, United States
Status: Withdrawn
Oncare Hawaii Inc-POB II
Honolulu, Hawaii, United States
Status: Withdrawn
OnCare Hawaii-Liliha
Honolulu, Hawaii, United States
Status: Withdrawn
Queen's Medical Center
Honolulu, Hawaii, United States
Status: Withdrawn
Straub Clinic and Hospital
Honolulu, Hawaii, United States
Status: Withdrawn
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Status: Withdrawn
Castle Medical Center
Kailua, Hawaii, United States
Status: Withdrawn
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, United States
Status: Withdrawn
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Kootenai Medical Center
Coeur D'Alene, Idaho, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Kootenai Cancer Center
Post Falls, Idaho, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Kootenai Cancer
Sandpoint, Idaho, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Saint Joseph Medical Center
Bloomington, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Canton
Canton, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Memorial Hospital of Carbondale
Carbondale, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Carthage
Carthage, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Centralia Oncology Clinic
Centralia, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Cancer Care Center of Decatur
Decatur, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Central Illinois CCOP
Decatur, Illinois, United States
Status: Recruiting
Contact: Anne S. Tsao - 713-792-6363
Decatur Memorial Hospital
Decatur, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Crossroads Cancer Center
Effingham, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Eureka
Eureka, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare Galesburg
Galesburg, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Western Illinois Cancer Treatment Center
Galesburg, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Macomb
Macomb, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Radiation Oncology of Northern Illinois
Ottawa, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Pekin
Pekin, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Pekin Cancer Treatment Center
Pekin, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Peoria
Peoria, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
OSF Saint Francis Medical Center
Peoria, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
Peoria, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Peru
Peru, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Valley Radiation Oncology
Peru, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Princeton
Princeton, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Central Illinois Hematology Oncology Center
Springfield, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Memorial Medical Center
Springfield, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Southern Illinois University School of Medicine
Springfield, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Springfield Clinic
Springfield, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Franciscan St. Francis Health-Beech Grove
Beech Grove, Indiana, United States
Status: Withdrawn
Franciscan Saint Francis Health-Indianapolis
Indianapolis, Indiana, United States
Status: Withdrawn
Reid Hospital and Health Care Services
Richmond, Indiana, United States
Status: Active, not recruiting
Oncology Hematology Care Inc-Crestview
Crestview Hills, Kentucky, United States
Status: Active, not recruiting
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States
Status: Withdrawn
Michigan Cancer Research Consortium CCOP
Ann Arbor, Michigan, United States
Status: Terminated
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Status: Recruiting
Contact: Anne S. Tsao - 713-792-6363
Oakwood Hospital and Medical Center
Dearborn, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Henry Ford Hospital
Detroit, Michigan, United States
Status: Recruiting
Contact: Robert A. Chapman - 313-916-1784
Saint John Hospital and Medical Center
Detroit, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States
Status: Recruiting
Contact: Shirish M. Gadgeel - 313-576-9363
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States
Status: Recruiting
Contact: Shirish M. Gadgeel - 313-576-9363
Genesys Hurley Cancer Institute
Flint, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Genesys Regional Medical Center-West Flint Campus
Flint, Michigan, United States
Status: Withdrawn
Hurley Medical Center
Flint, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Allegiance Health
Jackson, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Sparrow Hospital
Lansing, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Saint Mary Mercy Hospital
Livonia, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Saint Joseph Mercy Oakland
Pontiac, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Saint Joseph Mercy Port Huron
Port Huron, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Saint Mary's of Michigan
Saginaw, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Saint John Macomb-Oakland Hospital
Warren, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella - 734-712-4673
Singing River Hospital
Pascagoula, Mississippi, United States
Status: Recruiting
Contact: James E. Clarkson - 228-809-5292
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Saint Francis Medical Center
Cape Girardeau, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Southeast Cancer Center
Cape Girardeau, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Missouri Baptist Medical Center
Saint Louis, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Billings Clinic Cancer Center
Billings, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Frontier Cancer Center and Blood Institute-Billings
Billings, Montana, United States
Status: Terminated
Montana Cancer Consortium CCOP
Billings, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint Vincent Healthcare
Billings, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Bozeman Deaconess Cancer Center
Bozeman, Montana, United States
Status: Withdrawn
Bozeman Deaconess Hospital
Bozeman, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Great Falls Clinic
Great Falls, Montana, United States
Status: Terminated
Saint Peter's Community Hospital
Helena, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Glacier Oncology PLLC
Kalispell, Montana, United States
Status: Terminated
Kalispell Regional Medical Center
Kalispell, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Community Medical Hospital
Missoula, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Montana Cancer Specialists
Missoula, Montana, United States
Status: Terminated
Saint Patrick Hospital - Community Hospital
Missoula, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Carolina Surgical Clinic of Charlotte PA
Charlotte, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Oncology Specialists of Charlotte
Charlotte, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Southern Oncology Specialists-Charlotte
Charlotte, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Hendersonville Hematology and Oncology at Pardee
Hendersonville, North Carolina, United States
Status: Recruiting
Contact: James E. Radford - 828-696-4716
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, United States
Status: Recruiting
Contact: James E. Radford - 828-696-4716
Lake Norman Hematology Oncology Specialists-Huntersville
Huntersville, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Southern Oncology Specialists-Huntersville
Huntersville, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Matthews Radiation Oncology Center
Matthews, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Novant Health Cancer Specialists-Matthews
Matthews, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Lake Norman Hematology Oncology Specialists-Mooresville
Mooresville, North Carolina, United States
Status: Recruiting
Contact: Justin P. Favaro - 704-384-5369
Iredell Memorial Hospital
Statesville, North Carolina, United States
Status: Recruiting
Contact: Ruby A. Grimm - 704-873-5661
Southeast Cancer Control Consortium CCOP
Winston-Salem, North Carolina, United States
Status: Recruiting
Contact: Anne S. Tsao - 713-792-6363
Strecker Cancer Center-Belpre
Belpre, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Adena Regional Medical Center
Chillicothe, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Oncology Hematology Care Inc - Anderson
Cincinnati, Ohio, United States
Status: Active, not recruiting
Oncology Hematology Care Inc - Kenwood
Cincinnati, Ohio, United States
Status: Active, not recruiting
Oncology Hematology Care Inc-Blue Ash
Cincinnati, Ohio, United States
Status: Active, not recruiting
Oncology Hematology Care Inc-Eden Park
Cincinnati, Ohio, United States
Status: Active, not recruiting
Oncology Hematology Care Inc-Mercy West
Cincinnati, Ohio, United States
Status: Active, not recruiting
Columbus CCOP
Columbus, Ohio, United States
Status: Terminated
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Doctors Hospital
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Grant Medical Center
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Mount Carmel Health Center West
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Riverside Methodist Hospital
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
The Mark H Zangmeister Center
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 800-446-5532
Dayton CCOP
Dayton, Ohio, United States
Status: Terminated
Good Samaritan Hospital - Dayton
Dayton, Ohio, United States
Status: Active, not recruiting
Grandview Hospital
Dayton, Ohio, United States
Status: Terminated
Miami Valley Hospital
Dayton, Ohio, United States
Status: Active, not recruiting
Samaritan North Health Center
Dayton, Ohio, United States
Status: Active, not recruiting
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Delaware Radiation Oncology
Delaware, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Grady Memorial Hospital
Delaware, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Oncology Hematology Care Inc-Healthplex
Fairfield, Ohio, United States
Status: Active, not recruiting
Blanchard Valley Hospital
Findlay, Ohio, United States
Status: Active, not recruiting
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, United States
Status: Active, not recruiting
Wayne Hospital
Greenville, Ohio, United States
Status: Active, not recruiting
Kettering Medical Center
Kettering, Ohio, United States
Status: Active, not recruiting
Fairfield Medical Center
Lancaster, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Marietta Memorial Hospital
Marietta, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Knox Community Hospital
Mount Vernon, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Licking Memorial Hospital
Newark, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Newark Radiation Oncology
Newark, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Southern Ohio Medical Center
Portsmouth, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Springfield Regional Medical Center
Springfield, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-488-2745 - sheree@columbusccop.org
Upper Valley Medical Center
Troy, Ohio, United States
Status: Active, not recruiting
Saint Ann's Hospital
Westerville, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-566-3275
Greene Memorial Hospital
Xenia, Ohio, United States
Status: Terminated
Genesis HealthCare System
Zanesville, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-488-2745 - sheree@columbusccop.org
Clackamas Radiation Oncology Center
Clackamas, Oregon, United States
Status: Active, not recruiting
Providence Milwaukie Hospital
Milwaukie, Oregon, United States
Status: Terminated
Providence Newberg Medical Center
Newberg, Oregon, United States
Status: Active, not recruiting
Providence Willamette Falls Medical Center
Oregon City, Oregon, United States
Status: Active, not recruiting
Providence Portland Medical Center
Portland, Oregon, United States
Status: Recruiting
Contact: Keith S. Lanier - 503-215-6412
Providence Saint Vincent Medical Center
Portland, Oregon, United States
Status: Active, not recruiting
SWOG
Portland, Oregon, United States
Status: Recruiting
Contact: Anne S. Tsao - astsao@mdanderson.org
Western Oncology Research Consortium
Portland, Oregon, United States
Status: Terminated
Greenville Health System Cancer Institute-Easley
Easley, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Andrews
Greenville, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Butternut
Greenville, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Faris
Greenville, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Memorial Hospital
Greenville, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Cancer Centers of the Carolinas-Greer Medical Oncology
Greer, South Carolina, United States
Status: Withdrawn
Greenville Health System Cancer Institute-Greer
Greer, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina, United States
Status: Recruiting
Contact: Jeffrey K. Giguere - 864-241-6251
Wellmont Medical Associates Oncology and Hematology-Bristol
Bristol, Tennessee, United States
Status: Active, not recruiting
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, United States
Status: Recruiting
Contact: Asheesh Shipstone - 423-578-8538
Wellmont Medical Associates Oncology and Hematology-Kingsport
Kingsport, Tennessee, United States
Status: Recruiting
Contact: Asheesh Shipstone - 423-578-8538
M D Anderson Cancer Center
Houston, Texas, United States
Status: Recruiting
Contact: Anne S. Tsao - 713-792-3245
M D Anderson Cancer Center
Houston, Texas, United States
Status: Active, not recruiting
Southwest Oncology Group (SWOG) Research Base
San Antonio, Texas, United States
Status: Recruiting
Contact: Anne S. Tsao - astsao@mdanderson.org
Danville Hematology Oncology
Danville, Virginia, United States
Status: Recruiting
Contact: Qiwei W. Gai - 434-793-0044
Danville Regional Medical Center
Danville, Virginia, United States
Status: Recruiting
Contact: Timothy W. Brotherton - 434-793-0044
Southwest VA Regional Cancer Center
Norton, Virginia, United States
Status: Recruiting
Contact: Asheesh Shipstone - 423-578-8538
Cancer Care Center at Island Hospital
Anacortes, Washington, United States
Status: Active, not recruiting
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, United States
Status: Active, not recruiting
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington, United States
Status: Active, not recruiting
Highline Medical Center-Main Campus
Burien, Washington, United States
Status: Active, not recruiting
Swedish Medical Center-Edmonds
Edmonds, Washington, United States
Status: Active, not recruiting
Swedish Cancer Institute-Issaquah
Issaquah, Washington, United States
Status: Active, not recruiting
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, United States
Status: Active, not recruiting
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington, United States
Status: Active, not recruiting
Saint John Medical Center
Longview, Washington, United States
Status: Active, not recruiting
Skagit Valley Hospital
Mount Vernon, Washington, United States
Status: Active, not recruiting
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington, United States
Status: Active, not recruiting
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Seattle, Washington, United States
Status: Active, not recruiting
Group Health Cooperative-Seattle
Seattle, Washington, United States
Status: Active, not recruiting
Harborview Medical Center
Seattle, Washington, United States
Status: Terminated
Minor and James Medical PLLC
Seattle, Washington, United States
Status: Active, not recruiting
Swedish Medical Center-Ballard Campus
Seattle, Washington, United States
Status: Active, not recruiting
Swedish Medical Center-First Hill
Seattle, Washington, United States
Status: Active, not recruiting
The Polyclinic
Seattle, Washington, United States
Status: Terminated
University of Washington Medical Center
Seattle, Washington, United States
Status: Active, not recruiting
United General Hospital
Sedro-Woolley, Washington, United States
Status: Terminated
Cancer Care Northwest - Spokane South
Spokane, Washington, United States
Status: Active, not recruiting
Evergreen Hematology and Oncology PS
Spokane, Washington, United States
Status: Active, not recruiting
Rockwood Clinic
Spokane, Washington, United States
Status: Terminated
Compass Oncology Vancouver
Vancouver, Washington, United States
Status: Terminated
PeaceHealth Southwest Medical Center
Vancouver, Washington, United States
Status: Active, not recruiting
Wenatchee Valley Hospital and Clinics
Wenatchee, Washington, United States
Status: Active, not recruiting
Rocky Mountain Oncology
Casper, Wyoming, United States
Status: Terminated
Big Horn Basin Cancer Center
Cody, Wyoming, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Billings Clinic-Cody
Cody, Wyoming, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Welch Cancer Center
Sheridan, Wyoming, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Start Date
March 2010
Sponsors
National Cancer Institute (NCI)
Source
National Cancer Institute (NCI)
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page