Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy
Conditions
Malignant Mesothelioma
Conditions: official terms
Lung Neoplasms - Mesothelioma
Conditions: Keywords
epithelial mesothelioma, sarcomatous mesothelioma, stage II malignant mesothelioma, stage III malignant mesothelioma, stage IV malignant mesothelioma
Study Type
Interventional
Study Phase
Phase 2
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: pemetrexed disodium Type: Drug
Name: clinical observation Type: Other
Overall Status
Recruiting
Summary
RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This randomized phase II trial is studying how well pemetrexed disodium or observation works in treating patients with malignant pleural mesothelioma without progressive disease after first-line chemotherapy.
Detailed Description
OBJECTIVES:

Primary

- To determine if maintenance therapy with pemetrexed disodium versus observation improves progression-free survival of patients with malignant pleural mesothelioma who have at least stable disease after completion of first-line therapy comprising pemetrexed disodium with cisplatin or carboplatin.

Secondary

- To determine the overall survival of patients treated with this regimen versus observation.

- To evaluate the frequency of responses in patients treated with this regimen.

- To assess the toxicity of this regimen in these patients.

OUTLINE: This is a multicenter study. Patients are stratified according to first-line chemotherapy regimen (cisplatin/pemetrexed disodium vs carboplatin/pemetrexed disodium), histologic subtype (epithelioid vs other) and number of courses received (< 6 vs 6).

- Arm I: Patients receive pemetrexed disodium IV over 10 minutes on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

- Arm II: Patients undergo observation until disease progression. After completion of study therapy, patients are followed up every 6 months for 3 years.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically confirmed malignant pleural mesothelioma meeting 1 of the following cell types:

- Epithelial

- Sarcomatoid

- Mixed type

- Histologically documented malignant pleural mesothelioma, epithelial, sarcomatoid or mixed type, not amenable to surgical resection

- Prior treatment

- Currently receiving first-line treatment with pemetrexed + platinum; patients are to be registered to Cancer and Leukemia Group B (CALGB) 30901 no later than the last day of cycle 4 of first line therapy

- Prior intracavitary cytotoxic or sclerosing therapy (including bleomycin) are acceptable; prior intrapleural cytotoxic chemotherapy will not be considered systemic chemotherapy

- Prior surgical treatment is allowed

- Prior radiation therapy is allowed

- Non-pregnant and non-nursing; women of child bearing potential and men must agree to use an appropriate method of birth control throughout their participation in this study; appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives (Norplant), or double barrier methods (diaphragm plus condom)

- RANDOMIZATION ELIGIBILITY CRITERIA

- Patients with complete response, partial response, or stable disease following 4, 5 or 6 cycles of first-line chemotherapy with pemetrexed AND either cisplatin or carboplatin; a maximum of 6 cycles of chemotherapy may have been given

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

- Granulocytes >= 1,500/ul

- Platelet count >= 100,000/ul

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) =< 2 x ULN

- Calculated creatinine clearance >= 45 ml/min

- Disease not amenable to surgery

- Must be enrolled on imaging protocol CALGB-580903

- Complete response, partial response, or stable disease after completion of 4 courses of first-line chemotherapy comprising pemetrexed disodium AND cisplatin or carboplatin

- Study therapy will begin within 9 weeks following day 1 of cycle 4 of first-line treatment

- No clinically significant pleural or peritoneal effusions that cannot be adequately managed by drainage before or during pemetrexed disodium

PATIENT CHARACTERISTICS:

- ECOG performance status of 0-1

- Life expectancy ≥ 12 weeks

- Granulocytes ≥ 1,500/μL

- Platelet count ≥ 100,000/μL

- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST ≤ 2 times ULN

- Creatinine clearance ≥ 45 mL/min

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No psychiatric illness that would prevent the patient from giving informed consent

- No second malignancy except non-melanoma skin cancer or carcinoma in situ of the cervix unless curatively treated with no evidence of active disease for ≥ 5 years

- No medical conditions that, in the opinion of the treating physician, would make study treatment unreasonably hazardous for the patient including, but not limited to, the following:

- Ongoing or active infection such as HIV positivity

- Inability to take oral medications

- Psychiatric illness/social situations that would limit compliance with study requirements

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Prior intracavitary cytotoxic or sclerosing therapy (including bleomycin) allowed

- Prior intrapleural cytotoxic chemotherapy not considered systemic chemotherapy

- Prior surgery allowed

- Prior radiotherapy allowed

- No concurrent palliative radiotherapy

- No concurrent hormones or other chemotherapeutic agents except for the following:

- Steroids for adrenal failure

- Hormones for nondisease-related conditions (e.g., insulin for diabetes)

- Intermittent use of dexamethasone as an antiemetic or premedication for pemetrexed disodium
Locations
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Status: Recruiting
Contact: Clinical Trials Office - All Mayo Clinic Locations - 507-538-7623
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Status: Recruiting
Contact: Clinical Trials Office - UCSF Helen Diller Family Comprehensi - 877-827-3222
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
New Britain, Connecticut, United States
Status: Recruiting
Contact: Clinical Trials Office - George Bray Cancer Center - 860-224-5660
Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, United States
Status: Recruiting
Contact: Clinical Trials Office - Tunnell Cancer Center - 302-645-3171
CCOP - Christiana Care Health Services
Newark, Delaware, United States
Status: Recruiting
Contact: Clinical Trial Office - CCOP - Christiana Care Health Services - 302-623-4450
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, United States
Status: Recruiting
Contact: Clinical Trials Office - Saint Alphonsus Cancer Care Center - 208-367-7954
Illinois CancerCare - Bloomington
Bloomington, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-662-2102
St. Joseph Medical Center
Bloomington, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-662-3311
Illinois CancerCare - Canton
Canton, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-647-5240
Illinois CancerCare - Carthage
Carthage, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 217-357-6877
University of Chicago Cancer Research Center
Chicago, Illinois, United States
Status: Recruiting
Contact: Clinical Trials Office - University of Chicago Cancer Research - 773-834-7424
Eureka Community Hospital
Eureka, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-467-2371
Illinois CancerCare - Eureka
Eureka, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-467-2371
Galesburg Clinic, PC
Galesburg, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-344-1000
Illinois CancerCare - Havana
Havana, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-543-8557
Illinois CancerCare - Kewanee Clinic
Kewanee, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-852-0598
La Grange Memorial Hospital
La Grange, Illinois, United States
Status: Recruiting
Contact: Clinical Trials Office - La Grange Memorial Hospital - 630-856-7526
Illinois CancerCare - Macomb
Macomb, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-833-3503
Illinois CancerCare - Monmouth
Monmouth, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-734-3141
OSF Holy Family Medical Center
Monmouth, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-734-3141
BroMenn Regional Medical Center
Normal, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-454-1400
Community Cancer Center
Normal, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-451-8500
Illinois CancerCare - Community Cancer Center
Normal, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-662-2102
Community Hospital of Ottawa
Ottawa, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-433-3100
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-431-9270
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-353-0512
Illinois CancerCare - Pekin
Pekin, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-353-0214
CCOP - Illinois Oncology Research Association
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-243-3605
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Status: Recruiting
Contact: Clinical Trials Office - Methodist Medical Center of Illinois - 309-243-3000
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-243-3000
OSF St. Francis Medical Center
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-655-2000
Proctor Hospital
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 309-691-1000
Illinois CancerCare - Peru
Peru, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-780-3185
Illinois Valley Community Hospital
Peru, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-223-3000
Illinois CancerCare - Princeton
Princeton, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-875-3010
Illinois CancerCare - Spring Valley
Spring Valley, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 815-664-1487
Elkhart Clinic, LLC
Elkhart, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Elkhart General Hospital
Elkhart, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Michiana Hematology-Oncology, PC - Elkhart
Elkhart, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Howard Community Hospital
Kokomo, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Michiana Hematology-Oncology, PC - South Bend
Mishawaka, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Saint Joseph Regional Medical Center
Mishawaka, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Michiana Hematology Oncology PC - Plymouth
Plymouth, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Memorial Hospital of South Bend
South Bend, Indiana, United States
Status: Recruiting
Contact: Clinical Trials Office - Memorial Hospital of South Bend - 800-284-7370
Michiana Hematology Oncology PC - La Porte
Westville, Indiana, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States
Status: Recruiting
Contact: Donald B. Wender, MD, PhD - 712-252-0088
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, United States
Status: Recruiting
Contact: Donald B. Wender, MD, PhD - 712-252-0088
St. Luke's Regional Medical Center
Sioux City, Iowa, United States
Status: Recruiting
Contact: Donald B. Wender, MD, PhD - 712-252-0088
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas-Independence
Independence, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Lawrence Memorial Hospital
Lawrence, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Liberal
Liberal, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - McPherson
McPherson, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Newton
Newton, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Salina
Salina, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Associates in Womens Health, PA - North Review
Wichita, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
CCOP - Wichita
Wichita, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, United States
Status: Recruiting
Contact: Shaker R. Dakhil, MD, FACP - 316-262-4467
Ochsner Health Center - Bluebonnet
Baton Rouge, Louisiana, United States
Status: Recruiting
Contact: Frank E. Mott - 225-761-5200
Ochsner Health Center - Covington
Covington, Louisiana, United States
Status: Recruiting
Contact: Frank E. Mott - 985-875-2828
CCOP - Ochsner
New Orleans, Louisiana, United States
Status: Recruiting
Contact: Frank E. Mott - 504-842-3910
New Orleans Cancer Institute at Memorial Medical Center
New Orleans, Louisiana, United States
Status: Recruiting
Contact: Frank E. Mott - 504-894-2700
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, United States
Status: Recruiting
Contact: Frank E. Mott - 504-842-4360
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, United States
Status: Recruiting
Contact: Clinical Trials Office - Greenebaum Cancer Center at Universit - 800-888-8823
Veterans Affairs Medical Center - Baltimore
Baltimore, Maryland, United States
Status: Recruiting
Contact: Martin J. Edelman, MD - 410-328-2703
Union Hospital of Cecil County
Elkton MD, Maryland, United States
Status: Recruiting
Contact: Stephen S. Grubbs, MD - 302-366-1200
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, United States
Status: Recruiting
Contact: Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp - 313-593-8090
Genesys Hurley Cancer Institute
Flint, Michigan, United States
Status: Recruiting
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute - 810-762-8057
Hurley Medical Center
Flint, Michigan, United States
Status: Recruiting
Contact: Clinical Trials Office - Hurley Medical Center - 810-762-8057
Genesys Regional Medical Center
Grand Blanc, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, United States
Status: Recruiting
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo - 313-343-3166
Foote Memorial Hospital
Jackson, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Sparrow Regional Cancer Center
Lansing, Michigan, United States
Status: Recruiting
Contact: Clinical Trials Office - Sparrow Regional Cancer Center - 517-364-2890
St. Mary Mercy Hospital
Livonia, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
St. Joseph Mercy Oakland
Pontiac, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, United States
Status: Recruiting
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw - 989-776-8411
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph, Michigan, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
Lakeside Cancer Specialists, PLLC
Saint Joseph, Michigan, United States
Status: Recruiting
Contact: Rafat H. Ansari, MD, FACP - 574-234-5123
St. John Macomb Hospital
Warren, Michigan, United States
Status: Recruiting
Contact: Philip J. Stella, MD - 734-712-1000
St. Joseph's Medical Center
Brainerd, Minnesota, United States
Status: Recruiting
Contact: Daniel Nikcevich, MD, PhD - 218-786-3625
CCOP - Duluth
Duluth, Minnesota, United States
Status: Recruiting
Contact: Daniel Nikcevich, MD, PhD - 218-786-3625
Essentia Health - Duluth Clinic
Duluth, Minnesota, United States
Status: Recruiting
Contact: Clinical Trials Office - Essentia Health - Duluth Clinic - 218-786-3308
Miller - Dwan Medical Center
Duluth, Minnesota, United States
Status: Recruiting
Contact: Daniel Nikcevich, MD, PhD - 218-786-3625
Masonic Cancer Center at University of Minnesota
Minneapolis, Minnesota, United States
Status: Recruiting
Contact: Clinical Trials Office - Masonic Cancer Center at University o - 612-624-2620
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Status: Recruiting
Contact: Clinical Trials Office - All Mayo Clinic Locations - 507-538-7623
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, United States
Status: Recruiting
Contact: John A. Ellerton, MD, CM - 702-384-0013
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States
Status: Recruiting
Contact: John A. Ellerton, MD, CM - 702-384-0013
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees, New Jersey, United States
Status: Recruiting
Contact: Clinical Trials Office - Cancer Institute of New Jersey at Coo - 856-325-6757
CCOP - Hematology-Oncology Associates of Central New York
East Syracuse, New York, United States
Status: Recruiting
Contact: Jeffrey J. Kirshner, MD - 315-472-7504
SUNY Upstate Medical University Hospital
Syracuse, New York, United States
Status: Recruiting
Contact: Clinical Trials Office - SUNY Upstate Medical University Hospi - 315-464-5476
Duke Cancer Institute
Durham, North Carolina, United States
Status: Recruiting
Contact: Clinical Trials Office - Duke Cancer Institute - 888-275-3853
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, United States
Status: Recruiting
Contact: James N. Atkins, MD - 919-580-0000
Kinston Medical Specialists
Kinston, North Carolina, United States
Status: Recruiting
Contact: Peter R. Watson, MD - 252-559-2200
Iredell Memorial Hospital
Statesville, North Carolina, United States
Status: Recruiting
Contact: Ruby A. Grimm, MD - 704-873-2219
Medcenter One Hospital Cancer Care Center
Bismarck, North Dakota, United States
Status: Recruiting
Contact: John T. Reynolds - 701-323-5741
Mid Dakota Clinic, PC
Bismarck, North Dakota, United States
Status: Recruiting
Contact: Clinical Trials Office - Mid Dakota Clinic, PC - 701-530-6950
St. Alexius Medical Center Cancer Center
Bismarck, North Dakota, United States
Status: Recruiting
Contact: Clinical Trials Office - St. Alexius Medical Center Cancer Cen - 701-530-6950
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, United States
Status: Recruiting
Contact: Clinical Trials Office - Akron City Hospital - 330-375-6101
Barberton Citizens Hospital
Barberton, Ohio, United States
Status: Recruiting
Contact: Jennifer E. Payne - 330-745-1611
Cleveland Clinic Beachwood Family Health and Surgery Center
Beachwood, Ohio, United States
Status: Recruiting
Contact: Anjali S. Advani - 216-839-3200
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio, United States
Status: Recruiting
Contact: Clinical Trials Office - Cleveland Clinic Cancer Center at Fai - 216-476-9362
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States
Status: Recruiting
Contact: Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente - 866-223-8100
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Status: Recruiting
Contact: Ohio State University Cancer Clinical Trial Matching Service - 866-627-7616 - Jamesline@osumc.edu
Cleveland Clinic Cancer Center
Independence, Ohio, United States
Status: Recruiting
Contact: Anjali S. Advani - 216-524-7979
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights, Ohio, United States
Status: Recruiting
Contact: Anjali S. Advani - 440-312-4500
Parma Community General Hospital
Parma, Ohio, United States
Status: Recruiting
Contact: Clinical Trials Office - Parma Community General Hospital - 440-743-4747
North Coast Cancer Care, Incorporated
Sandusky, Ohio, United States
Status: Recruiting
Contact: Anjali S. Advani - 419-626-9090
Cleveland Clinic Foundation - Strongsville
Strongsville, Ohio, United States
Status: Recruiting
Contact: Anjali S. Advani - 440-878-2500
Cleveland Clinic - Wooster
Wooster, Ohio, United States
Status: Recruiting
Contact: Clinical Trials Office - Cleveland Clinic - Wooster - 800-862-7798
Clackamas Radiation Oncology Center
Clackamas, Oregon, United States
Status: Recruiting
Contact: Alison K. Conlin - 503-513-3300
Providence Milwaukie Hospital
Milwaukie, Oregon, United States
Status: Recruiting
Contact: Alison K. Conlin - 503-513-8300
Providence Newberg Medical Center
Newberg, Oregon, United States
Status: Recruiting
Contact: Alison K. Conlin - 503-537-1555
Willamette Falls Hospital
Oregon City, Oregon, United States
Status: Recruiting
Contact: Alison K. Conlin - 503-650-6758
CCOP - Columbia River Oncology Program
Portland, Oregon, United States
Status: Recruiting
Contact: Alison K. Conlin - 503-216-6260
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, United States
Status: Recruiting
Contact: Clinical Trials Office - Providence Cancer Center at Providenc - 503-215-6412
Providence St. Vincent Medical Center
Portland, Oregon, United States
Status: Recruiting
Contact: Clinical Trials Office - Providence St. Vincent Medical Center - 503-215-6412
Rosenfeld Cancer Center at Abington Memorial Hospital
Abington, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - Rosenfeld Cancer Center at Abington M - 215-481-2402
Geisinger Cancer Institute at Geisinger Health
Danville, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - Geisinger Cancer Institute - 570-271-5251
Geisinger Hazleton Cancer Center
Hazleton, Pennsylvania, United States
Status: Recruiting
Contact: Rajiv Panikkar - 570-459-2901
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - Abramson Cancer Center of the Univers - 800-474-9892
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - Fox Chase Cancer Center - Philadelphi - 215-728-4790
UPMC Cancer Centers
Pittsburgh, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - UPMC Cancer Centers - 412-647-8073
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, United States
Status: Recruiting
Contact: Rajiv Panikkar - 814-231-4560
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States
Status: Recruiting
Contact: Clinical Trials Office - Frank M. and Dorothea Henry Cancer Ce - 570-271-5251
Roper St. Francis Cancer Center at Roper Hospital
Charleston, South Carolina, United States
Status: Recruiting
Contact: James M. Orcutt, MD - 843-577-2276
Danville Regional Medical Center
Danville, Virginia, United States
Status: Recruiting
Contact: Clinical Trials Office - Danville Regional Medical Center - 434-799-3753
Northwest Cancer Specialists at Vancouver Cancer Center
Vancouver, Washington, United States
Status: Recruiting
Contact: Alison K. Conlin - 360-944-9889
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, United States
Status: Recruiting
Contact: Alison K. Conlin - 360-514-2174
Gundersen Lutheran Center for Cancer and Blood
La Crosse, Wisconsin, United States
Status: Recruiting
Contact: Clinical Trials Office - Gundersen Lutheran Cancer Center - 608-775-2385 - cancerctr@gundluth.org
Start Date
April 2010
Sponsors
Alliance for Clinical Trials in Oncology
Source
Alliance for Clinical Trials in Oncology
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page