Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma
Conditions
Non-Hodgkin's Lymphoma (NHL)
Conditions: official terms
Lymphoma - Lymphoma, Mantle-Cell - Lymphoma, Non-Hodgkin
Conditions: Keywords
Mantle Cell Lymphoma, non-Hodgkin lymphoma (NHL), temsirolimus
Study Type
Interventional
Study Phase
Phase 4
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: temsirolimus Type: Drug
Name: temsirolimus Type: Drug
Overall Status
Recruiting
Summary
This study will compare the effectiveness and safety of two different doses of temsirolimus (Torisel).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Have confirmed mantle cell lymphoma diagnosis.

- Have measurable disease.

- Have received at least 2 prior treatment, which may include stem cell transplant.

- Have adequate organ and bone marrow function.

- There are other criteria--please discuss with your doctor.

Exclusion Criteria:

- Had any prior treatment with temsirolimus or mTOR inhibitor.

- Had allogeneic stem cell transplant within last 6 months and on immunosuppressive therapy.

- Has active or untreated brain or central nervous system metastases.

- There are other criteria--please discuss with your doctor.
Locations
Dr. Jorge Antunez de Mayolo office
Miami, Florida, United States
Status: Recruiting
Dr. Luis Villa Private Office
Miami, Florida, United States
Status: Recruiting
Mercy Hospital
Miami, Florida, United States
Status: Recruiting
Mercy Research Institute
Miami, Florida, United States
Status: Recruiting
Presence Medical Group Hematology Oncology
Skokie, Illinois, United States
Status: Recruiting
Floyd Memorial Cancer Center of Indiana
New Albany, Indiana, United States
Status: Recruiting
Veterans Affairs New Jersey Healthcare System-Hematology/Oncology Section (111)
East Orange, New Jersey, United States
Status: Recruiting
Mercy Physicians of Oklahoma
Norman, Oklahoma, United States
Status: Recruiting
Mercy Physicians of Oklahoma
Oklahoma City, Oklahoma, United States
Status: Recruiting
Veterans Affairs Puget Sound Health Care System
Seattle, Washington, United States
Status: Recruiting
St George Hospital/
Kogarah, New South Wales, Australia
Status: Recruiting
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Status: Recruiting
Royal Hobart Hospital
Hobart, Tasmania, Australia
Status: Recruiting
Eastern Clinical Research Unit
Box Hill, Victoria, Australia
Status: Recruiting
The Alfred Hospital
Melbourn, Victoria, Australia
Status: Recruiting
Fakultni nemocnice Kralovske Vinohrady
Praha 10, Czech Republic
Status: Recruiting
Vseobecna fakultni nemocnice v Praze
Praha 2, Czech Republic
Status: Recruiting
CHU de Nancy
Vandoeuvre les Nancy, France
Status: Active, not recruiting
Klinik fuer Onkologie und Haematologie, Medizinische Klinik IV
Aachen, Germany
Status: Active, not recruiting
Klinikum Johannes-Gutenberg -Universitaet, III. Medizinische Klinik und Poliklinik
Mainz, Germany
Status: Recruiting
Universitätsmedizin
Mainz, Germany
Status: Recruiting
Divisione di Ematologia, Ospedale Ferrarotto
Catania, Italy
Status: Recruiting
Policlinico di Modena, Centro Oncologico Modenese
Modena, Italy
Status: Recruiting
SCDO Ematologia 2, AOU San Giovanni Battista
Torino, Italy
Status: Recruiting
Samsung Medical Center
Seoul, Korea, Republic of
Status: Terminated
Severance Hospital, Yonsei University
Seoul, Korea, Republic of
Status: Terminated
Klinika Hematologii i Transplantologii
Gdansk, Poland
Status: Recruiting
Malopolskie Centrum Medyczna S.C.
Krakow, Poland
Status: Recruiting
Institutul Clinic Fundeni Bucuresti, Sectia II Hematologie
Bucuresti, Romania
Status: Terminated
Spitalul Clinic Coltea, Clinica de Hematologie
Bucuresti, Romania
Status: Recruiting
Spitalul Universitar de Urgenta Bucuresti, Clinica de Hematologie
Bucuresti, Romania
Status: Recruiting
Republican Clinical Oncology Dispensary of the Ministry of Healthcare of Tatarstan Republic
Kazan, Russian Federation
Status: Terminated
Institute of Pediatric Hematology and Transplantology R.M.Gorbacheva
Saint-Petersburg, Russian Federation
Status: Recruiting
St.-Petersburg State Medical University I.P.Pavlov of Roszdrav
Saint-Petersburg, Russian Federation
Status: Recruiting
Clinical Centre of Serbia,Clinic of Hematology
Belgrade, Serbia
Status: Recruiting
Institute for Oncology and Radiology of Serbia
Belgrade, Serbia
Status: Recruiting
Oncology Institute of Vojvodina
Sremska Kamenica, Serbia
Status: Recruiting
Start Date
March 2011
Completion Date
July 2017
Sponsors
Pfizer
Source
Pfizer
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page