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Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
Conditions
Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) - Childhood Supratentorial Primitive Neuroectodermal Tumor - Ewing Sarcoma of Bone - Extraosseous Ewing Sarcoma - Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor - Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor - Peripheral Primitive Neuroectodermal Tumor of the Kidney - Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Conditions: official terms
Kidney Neoplasms - Neuroectodermal Tumors - Neuroectodermal Tumors, Primitive - Neuroectodermal Tumors, Primitive, Peripheral - Sarcoma - Sarcoma, Ewing
Study Type
Interventional
Study Phase
Phase 3
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: vincristine sulfate
Type: Drug
Name: doxorubicin hydrochloride
Type: Drug
Name: cyclophosphamide
Type: Drug
Name: ifosfamide
Type: Drug
Name: etoposide
Type: Drug
Name: topotecan hydrochloride
Type: Drug
Name: laboratory biomarker analysis
Type: Other
Overall Status
Recruiting
Summary
This randomized phase III trial studies combination chemotherapy to see how well it works compared to combination chemotherapy with topotecan hydrochloride in treating patients with non-metastatic extracranial Ewing sarcoma. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, ifosfamide, etoposide, and topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with topotecan hydrochloride in treating Ewing sarcoma.
Detailed Description
PRIMARY OBJECTIVES:
l. Test the effect of the combination of vincristine (vincristine sulfate), cyclophosphamide, and topotecan (topotecan hydrochloride) (VTC) added to the standard 5-drug chemotherapy interval-compressed backbone on event-free and overall survival of children and young adults with Ewing sarcoma.
SECONDARY OBJECTIVES:
I. To evaluate initial volumetric tumor size as a prognostic factor for event free survival (EFS) in patients with localized Ewing tumors.
II. To evaluate histologic response as a prognostic factor for EFS in patients with localized Ewing tumors.
III. To continue evaluation of biologic markers both as related to prognosis and as eventual therapeutic targets via encouraging concurrent enrollment on a Ewing sarcoma specimen-collection study.
IV. To evaluate imaging response by fludeoxyglucose F 18 (FDG)-positron emission tomography (PET) as a prognostic factor for EFS.
V. To evaluate the effects of the type of local therapy on EFS and overall survival.
VI. To evaluate the effect of local surgical margins in conjunction with histologic response on EFS in patients with localized Ewing tumors.
VII. To evaluate the effect of local therapy modality (surgery, radiotherapy, or a combination) as well as the type of surgical reconstruction on musculoskeletal complications.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I:
INDUCTION THERAPY: Patients receive vincristine sulfate intravenously (IV) on day 1 in weeks 1, 2, 5, 6, 9, and 10; doxorubicin hydrochloride IV on days 1 and 2 and cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 5, and 9; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 7, and 11.
CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7, 8, 9, 10, 13, 14, 17, 18, 21, and 22; doxorubicin hydrochloride IV on days 1 and 2 in weeks 1 and 9; cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 7, 9, 13, 17, and 21; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 5, 11, 15, and 19.
ARM II:
INDUCTION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 5, 6, 9, 10, 11 and 12; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1 and 9; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1 and 9, and on day 1 of weeks 5 and 11; ifosfamide and etoposide as in arm I; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 5 and 11.
CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7-10, 13-16, 19, and 20; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1, 7, and 15; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1, 7, and 15, and on day 1 in weeks 9, 13, and 19; ifosfamide IV over 1 hour and etoposide IV over 1- 2 hours on days 1-5 in weeks 3, 5, 11, 17, and 21; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 9,13, and 19.
Patients with responsive or stable disease undergo may undergo surgery alone in week 13 if lesion can be complete resected with negative margins and with reasonable functional result. Patients with unresectable lesions or inadequate margins after surgery receive radiotherapy during weeks 1-7. Patients with bulky lesions in surgically difficult sites such as the spine, skull, and periacetabular pelvis, patients with a poor response to induction chemotherapy, or those patients in whom surgery would result in unacceptable functional results may undergo radiotherapy alone in weeks 1-7 of consolidation therapy, and surgery should be performed after completion of consolidation chemotherapy. Patients with microscopic residual disease after planned pre-operative radiotherapy receive additional radiotherapy.
After completion of study therapy, patients are followed up every 3 months for 3 years and then every 6 months for 2 years.
l. Test the effect of the combination of vincristine (vincristine sulfate), cyclophosphamide, and topotecan (topotecan hydrochloride) (VTC) added to the standard 5-drug chemotherapy interval-compressed backbone on event-free and overall survival of children and young adults with Ewing sarcoma.
SECONDARY OBJECTIVES:
I. To evaluate initial volumetric tumor size as a prognostic factor for event free survival (EFS) in patients with localized Ewing tumors.
II. To evaluate histologic response as a prognostic factor for EFS in patients with localized Ewing tumors.
III. To continue evaluation of biologic markers both as related to prognosis and as eventual therapeutic targets via encouraging concurrent enrollment on a Ewing sarcoma specimen-collection study.
IV. To evaluate imaging response by fludeoxyglucose F 18 (FDG)-positron emission tomography (PET) as a prognostic factor for EFS.
V. To evaluate the effects of the type of local therapy on EFS and overall survival.
VI. To evaluate the effect of local surgical margins in conjunction with histologic response on EFS in patients with localized Ewing tumors.
VII. To evaluate the effect of local therapy modality (surgery, radiotherapy, or a combination) as well as the type of surgical reconstruction on musculoskeletal complications.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I:
INDUCTION THERAPY: Patients receive vincristine sulfate intravenously (IV) on day 1 in weeks 1, 2, 5, 6, 9, and 10; doxorubicin hydrochloride IV on days 1 and 2 and cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 5, and 9; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 7, and 11.
CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7, 8, 9, 10, 13, 14, 17, 18, 21, and 22; doxorubicin hydrochloride IV on days 1 and 2 in weeks 1 and 9; cyclophosphamide IV over 30-60 minutes on day 1 in weeks 1, 7, 9, 13, 17, and 21; and ifosfamide IV over 1 hour and etoposide IV over 1-2 hours on days 1-5 in weeks 3, 5, 11, 15, and 19.
ARM II:
INDUCTION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 5, 6, 9, 10, 11 and 12; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1 and 9; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1 and 9, and on day 1 of weeks 5 and 11; ifosfamide and etoposide as in arm I; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 5 and 11.
CONSOLIDATION THERAPY: Patients receive vincristine sulfate IV on day 1 in weeks 1, 2, 7-10, 13-16, 19, and 20; topotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1, 7, and 15; cyclophosphamide IV over 15-60 minutes on days 1-5 in weeks 1, 7, and 15, and on day 1 in weeks 9, 13, and 19; ifosfamide IV over 1 hour and etoposide IV over 1- 2 hours on days 1-5 in weeks 3, 5, 11, 17, and 21; and doxorubicin hydrochloride IV on days 1 and 2 in weeks 9,13, and 19.
Patients with responsive or stable disease undergo may undergo surgery alone in week 13 if lesion can be complete resected with negative margins and with reasonable functional result. Patients with unresectable lesions or inadequate margins after surgery receive radiotherapy during weeks 1-7. Patients with bulky lesions in surgically difficult sites such as the spine, skull, and periacetabular pelvis, patients with a poor response to induction chemotherapy, or those patients in whom surgery would result in unacceptable functional results may undergo radiotherapy alone in weeks 1-7 of consolidation therapy, and surgery should be performed after completion of consolidation chemotherapy. Patients with microscopic residual disease after planned pre-operative radiotherapy receive additional radiotherapy.
After completion of study therapy, patients are followed up every 3 months for 3 years and then every 6 months for 2 years.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 50 Years
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:
- Patients with newly diagnosed, biopsy confirmed, extracranial, non-metastatic Ewing sarcoma or primitive neuroectodermal tumor (PNET) of bone or soft tissue are eligible for this study; note:
- For the purpose of this study, chest wall tumors with ipsilateral pleural effusions, ipsilateral positive pleural fluid cytology or ipsilateral pleural based secondary tumor nodules will be considered localized disease
- Patients with regional node involvement, based on clinical suspicion confirmed by pathologic documentation are considered to be non-metastatic
- Patients with discontinuous osseous lesions within the same bone are considered to be non-metastatic
- Tumors arising in the bony skull (extra-dural) are considered to be extracranial
- Patient eligibility will be based on a diagnosis of Ewing sarcoma or PNET by institutional pathologist
- No prior chemotherapy or radiation therapy is allowed; patients should only have had a biopsy of the primary tumor without an attempt at complete or partial resection; patients will still be eligible if unplanned excision was attempted or accomplished as long as adequate imaging was obtained prior to surgery
- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or serum creatinine based on age/gender as follows:
- 1 month to < 6 months: 0.4 mg/dL
- 6 months to < 1 year: 0.5 mg/dL
- 1 to < 2 years: 0.6 mg/dL
- 2 to < 6 years: 0.8 mg/dL
- 6 to < 10 years: 1 mg/dL
- 10 to < 13 years: 1.2 mg/dL
- 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)
- >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)
- Total bilirubin < 1.5 x upper limit of normal (ULN) for age
- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age
- Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram
Exclusion Criteria:
- Patients must have no evidence of metastatic disease; metastatic disease:
- Are lesions which are discontinuous from the primary tumor, are not regional lymph nodes and do not share a body cavity with the primary tumor; if there is any doubt whether lesions are metastatic, a biopsy of those lesions should be taken
- Skeletal lesions in adjacent bones (trans-articular)
- Contralateral pleural effusion and contralateral pleural nodules
- Distant lymph node involvement
- Patients with pulmonary nodules are considered to have metastatic disease if the patient has:
- Solitary nodule > 0.5 cm or multiple nodules of > 0.3 cm unless biopsied and negative for Ewing's
- Biopsies of solitary nodule =< 0.5 cm or multiple nodules =< 0.3 cm are not required but if performed and positive indicate metastatic disease
- Patients whose tumors arise in the dural and intra-dural soft tissues of the cranium and spine are not eligible
- Patients with pathologic diagnoses other than Ewing sarcoma will be excluded
- Patients diagnosed with Ewing Sarcoma as a second malignant neoplasm are not eligible if they have received chemotherapy or radiation for the treatment of their primary malignancy
- Pregnant women will not be entered on this study; pregnancy tests must be obtained in female patients who are post-menarchal; lactating females may not participate unless they have agreed not to breastfeed their infants; males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method for the duration of the study treatment
- All patients and/or their parents or legal guardians must sign a written informed consent
- All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
- Patients with newly diagnosed, biopsy confirmed, extracranial, non-metastatic Ewing sarcoma or primitive neuroectodermal tumor (PNET) of bone or soft tissue are eligible for this study; note:
- For the purpose of this study, chest wall tumors with ipsilateral pleural effusions, ipsilateral positive pleural fluid cytology or ipsilateral pleural based secondary tumor nodules will be considered localized disease
- Patients with regional node involvement, based on clinical suspicion confirmed by pathologic documentation are considered to be non-metastatic
- Patients with discontinuous osseous lesions within the same bone are considered to be non-metastatic
- Tumors arising in the bony skull (extra-dural) are considered to be extracranial
- Patient eligibility will be based on a diagnosis of Ewing sarcoma or PNET by institutional pathologist
- No prior chemotherapy or radiation therapy is allowed; patients should only have had a biopsy of the primary tumor without an attempt at complete or partial resection; patients will still be eligible if unplanned excision was attempted or accomplished as long as adequate imaging was obtained prior to surgery
- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2 or serum creatinine based on age/gender as follows:
- 1 month to < 6 months: 0.4 mg/dL
- 6 months to < 1 year: 0.5 mg/dL
- 1 to < 2 years: 0.6 mg/dL
- 2 to < 6 years: 0.8 mg/dL
- 6 to < 10 years: 1 mg/dL
- 10 to < 13 years: 1.2 mg/dL
- 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)
- >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)
- Total bilirubin < 1.5 x upper limit of normal (ULN) for age
- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age
- Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram
Exclusion Criteria:
- Patients must have no evidence of metastatic disease; metastatic disease:
- Are lesions which are discontinuous from the primary tumor, are not regional lymph nodes and do not share a body cavity with the primary tumor; if there is any doubt whether lesions are metastatic, a biopsy of those lesions should be taken
- Skeletal lesions in adjacent bones (trans-articular)
- Contralateral pleural effusion and contralateral pleural nodules
- Distant lymph node involvement
- Patients with pulmonary nodules are considered to have metastatic disease if the patient has:
- Solitary nodule > 0.5 cm or multiple nodules of > 0.3 cm unless biopsied and negative for Ewing's
- Biopsies of solitary nodule =< 0.5 cm or multiple nodules =< 0.3 cm are not required but if performed and positive indicate metastatic disease
- Patients whose tumors arise in the dural and intra-dural soft tissues of the cranium and spine are not eligible
- Patients with pathologic diagnoses other than Ewing sarcoma will be excluded
- Patients diagnosed with Ewing Sarcoma as a second malignant neoplasm are not eligible if they have received chemotherapy or radiation for the treatment of their primary malignancy
- Pregnant women will not be entered on this study; pregnancy tests must be obtained in female patients who are post-menarchal; lactating females may not participate unless they have agreed not to breastfeed their infants; males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method for the duration of the study treatment
- All patients and/or their parents or legal guardians must sign a written informed consent
- All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
Locations
Children's Hospital of Alabama
Birmingham, Alabama, United States
University of Alabama at Birmingham
Status: Recruiting
Contact: Alyssa T. Reddy - 205-934-0309
Birmingham, Alabama, United States
University of South Alabama
Status: Recruiting
Contact: Alyssa T. Reddy - 205-934-0309
Mobile, Alabama, United States
Phoenix Childrens Hospital
Status: Terminated
Phoenix, Arizona, United States
University of Arizona Health Sciences Center
Status: Recruiting
Contact: Jessica Boklan - 602-546-0920
Tucson, Arizona, United States
Arkansas Children's Hospital
Status: Recruiting
Contact: Brenda J. Wittman - 520-626-9008
Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences
Status: Recruiting
Contact: David L. Becton - 501-364-7373
Little Rock, Arkansas, United States
Southern California Permanente Medical Group
Status: Withdrawn
Downey, California, United States
City of Hope
Status: Recruiting
Contact: Robert M. Cooper - 626-564-3455
Duarte, California, United States
Loma Linda University Medical Center
Status: Recruiting
Contact: Anna B. Pawlowska - 800-826-4673 - becomingapatient@coh.org
Loma Linda, California, United States
Miller Children's Hospital
Status: Recruiting
Contact: Antranik A. Bedros - 909-558-3375
Long Beach, California, United States
Cedars-Sinai Medical Center
Status: Recruiting
Contact: Amanda M. Termuhlen - 562-933-5437
Los Angeles, California, United States
Children's Hospital Los Angeles
Status: Recruiting
Contact: Fataneh (Fae) Majlessipour - 310-423-8965
Los Angeles, California, United States
David Geffen School of Medicine at UCLA
Status: Recruiting
Contact: Leo Mascarenhas - 323-361-4110
Los Angeles, California, United States
Mattel Children's Hospital UCLA
Status: Recruiting
Contact: Pamela H. Kempert - 310-825-6708
Los Angeles, California, United States
Children's Hospital Central California
Status: Recruiting
Contact: Pamela H. Kempert - 310-825-6708
Madera, California, United States
Children's Hospital and Research Center at Oakland
Status: Recruiting
Contact: Vonda L. Crouse - 866-353-5437
Oakland, California, United States
Kaiser Permanente-Oakland
Status: Recruiting
Contact: Carla B. Golden - 510-450-7600
Oakland, California, United States
Childrens Hospital of Orange County
Status: Recruiting
Contact: Steven K. Bergstrom - 626-564-3455
Orange, California, United States
University of California Medical Center At Irvine-Orange Campus
Status: Recruiting
Contact: Violet Shen - 714-997-3000
Orange, California, United States
Lucile Packard Children's Hospital Stanford University
Status: Recruiting
Contact: Leonard S. Sender - 877-827-8839 - ucstudy@uci.edu
Palo Alto, California, United States
UC Davis Comprehensive Cancer Center
Status: Recruiting
Contact: Neyssa M. Marina - 650-498-7061 - clinicaltrials@med.stanford.edu
Sacramento, California, United States
Rady Children's Hospital - San Diego
Status: Recruiting
Contact: Jay Michael S. Balagtas - 916-734-3089
San Diego, California, United States
University of California San Francisco Medical Center-Parnassus
Status: Recruiting
Contact: William D. Roberts - 858-966-5934
San Francisco, California, United States
Children's Hospital Colorado
Status: Recruiting
Contact: Steven G. DuBois - 877-827-3222
Aurora, Colorado, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Status: Recruiting
Contact: Timothy P. Garrington - 720-777-6672
Denver, Colorado, United States
Connecticut Children's Medical Center
Status: Recruiting
Contact: Jennifer J. Clark - 866-775-6246
Hartford, Connecticut, United States
Yale University
Status: Recruiting
Contact: Michael S. Isakoff - 860-545-9981
New Haven, Connecticut, United States
Alfred I duPont Hospital for Children
Status: Recruiting
Contact: Nina S. Kadan-Lottick - 203-785-5702
Wilmington, Delaware, United States
Children's National Medical Center
Status: Recruiting
Contact: Christopher N. Frantz - 302-651-5755
Washington, District of Columbia, United States
Lombardi Comprehensive Cancer Center at Georgetown University
Status: Recruiting
Contact: Jeffrey S. Dome - 202-884-2549
Washington, District of Columbia, United States
Broward Health Medical Center
Status: Recruiting
Contact: Aziza T. Shad - 202-444-0381
Fort Lauderdale, Florida, United States
Lee Memorial Health System
Status: Recruiting
Contact: Hector M. Rodriguez-Cortes - 954-355-5346
Fort Myers, Florida, United States
The Children's Hospital of Southwest Florida
Status: Withdrawn
Fort Myers, Florida, United States
University of Florida
Status: Recruiting
Contact: Emad K. Salman - 239-343-5333
Gainesville, Florida, United States
Memorial Healthcare System - Joe DiMaggio Children's Hospital
Status: Recruiting
Contact: Amy A. Smith - 352-273-8675
Hollywood, Florida, United States
Nemours Children's Clinic - Jacksonville
Status: Recruiting
Contact: Iftikhar Hanif - 954-265-2234
Jacksonville, Florida, United States
Baptist Hospital of Miami
Status: Recruiting
Contact: Scott M. Bradfield - 904-697-3529
Miami, Florida, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: Recruiting
Contact: Doured Daghistani - 800-599-2456 - cancerinfo@baptisthealth.net
Miami, Florida, United States
Florida Hospital
Status: Recruiting
Contact: Julio C. Barredo - 866-574-5124 - Sylvester@emergingmed.com
Orlando, Florida, United States
M D Anderson Cancer Center- Orlando
Status: Recruiting
Contact: Fouad M. Hajjar - 407-303-5623
Orlando, Florida, United States
Nemours Children's Hospital
Status: Recruiting
Contact: Vincent F. Giusti - 321-841-7246
Orlando, Florida, United States
Nemours Childrens Clinic - Orlando
Status: Recruiting
Contact: Ramamoorthy Nagasubramanian - 407-650-7150
Orlando, Florida, United States
Nemours Children's Clinic - Pensacola
Status: Withdrawn
Pensacola, Florida, United States
All Children's Hospital
Status: Recruiting
Contact: Jeffrey H. Schwartz - 904-697-3529
Saint Petersburg, Florida, United States
Saint Joseph Children's Hospital of Tampa
Status: Recruiting
Contact: Gregory A. Hale - 727-767-2423 - HamblinF@allkids.org
Tampa, Florida, United States
Saint Mary's Hospital
Status: Recruiting
Contact: Hardeo K. Panchoosingh - 800-882-4123
West Palm Beach, Florida, United States
Children's Healthcare of Atlanta - Egleston
Status: Recruiting
Contact: Narayana Gowda - 888-823-5923 - ctsucontact@westat.com
Atlanta, Georgia, United States
Georgia Regents University
Status: Recruiting
Contact: Howard M. Katzenstein - 800-811-8480
Augusta, Georgia, United States
Memorial Health University Medical Center
Status: Recruiting
Contact: Colleen H. McDonough - 706-721-1663 - cancer@georgiahealth.edu
Savannah, Georgia, United States
Tripler Army Medical Center
Status: Recruiting
Contact: J. M. Johnston - 912-350-8568
Honolulu, Hawaii, United States
University of Hawaii
Status: Recruiting
Contact: Jeremy V. Edwards - 808-433-6336
Honolulu, Hawaii, United States
Saint Luke's Mountain States Tumor Institute
Status: Recruiting
Contact: Robert W. Wilkinson - 808-983-6090
Boise, Idaho, United States
Lurie Children's Hospital-Chicago
Status: Recruiting
Contact: Eugenia Chang - 800-845-4624
Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
Status: Recruiting
Contact: David O. Walterhouse - 773-880-4562
Chicago, Illinois, United States
University of Illinois
Status: Recruiting
Contact: Susan L. Cohn - 773-834-7424
Chicago, Illinois, United States
Loyola University Medical Center
Status: Recruiting
Contact: Mary L. Schmidt - 312-355-3046
Maywood, Illinois, United States
Advocate Hope Children's Hospital
Status: Recruiting
Contact: Ricarchito B. Manera - 708-226-4357
Oak Lawn, Illinois, United States
Advocate Lutheran General Hospital
Status: Recruiting
Contact: Sharad N. Salvi - 847-723-7570
Park Ridge, Illinois, United States
Saint Jude Midwest Affiliate
Status: Recruiting
Contact: Jong H. Kwon - 847-384-3621
Peoria, Illinois, United States
Memorial Medical Center
Status: Recruiting
Contact: Pedro A. De Alarcon - 309-655-3258
Springfield, Illinois, United States
Saint John's Hospital
Status: Recruiting
Contact: Gregory P. Brandt - 217-545-7929
Springfield, Illinois, United States
Southern Illinois University
Status: Recruiting
Contact: Gregory P. Brandt - 217-545-7929
Springfield, Illinois, United States
Indiana University Medical Center
Status: Recruiting
Contact: Gregory P. Brandt - 217-545-7929
Indianapolis, Indiana, United States
Riley Hospital for Children
Status: Active, not recruiting
Indianapolis, Indiana, United States
Saint Vincent Hospital and Health Services
Status: Recruiting
Contact: Robert J. Fallon - 317-274-2552
Indianapolis, Indiana, United States
Raymond Blank Children's Hospital
Status: Recruiting
Contact: Bassem I. Razzouk - 317-338-2194
Des Moines, Iowa, United States
University of Iowa Hospitals and Clinics
Status: Recruiting
Contact: Wendy L. Woods-Swafford - 515-241-6729
Iowa City, Iowa, United States
Mercy Medical Center-Sioux City
Status: Recruiting
Contact: Ayman A. El-Sheikh - 800-237-1225
Sioux City, Iowa, United States
Saint Luke's Regional Medical Center
Status: Recruiting
Contact: Donald B. Wender - 712-252-0088
Sioux City, Iowa, United States
Siouxland Hematology Oncology Associates
Status: Recruiting
Contact: Donald B. Wender - 712-252-0088
Sioux City, Iowa, United States
University of Kentucky
Status: Recruiting
Contact: Donald B. Wender - 712-252-0088
Lexington, Kentucky, United States
Kosair Children's Hospital
Status: Recruiting
Contact: Martha F. Greenwood - 859-257-3379
Louisville, Kentucky, United States
Children's Hospital-Main Campus
Status: Recruiting
Contact: Salvatore J. Bertolone - 866-530-5516
New Orleans, Louisiana, United States
Ochsner Clinic Foundation
Status: Recruiting
Contact: Lolie C. Yu - 504-894-5377
New Orleans, Louisiana, United States
Tulane University Health Sciences Center
Status: Recruiting
Contact: Craig Lotterman - 888-562-4763
New Orleans, Louisiana, United States
Eastern Maine Medical Center
Status: Recruiting
Contact: Tammuella C. Singleton - 504-988-6121
Bangor, Maine, United States
Johns Hopkins University
Status: Recruiting
Contact: Sarah J. Fryberger - 207-973-4274
Baltimore, Maryland, United States
Sinai Hospital of Baltimore
Status: Recruiting
Contact: David M. Loeb - 410-955-8804 - jhcccro@jhmi.edu
Baltimore, Maryland, United States
University of Maryland Greenebaum Cancer Center
Status: Recruiting
Contact: Joseph M. Wiley - 410-601-6120 - pridgely@lifebridgehealth.org
Baltimore, Maryland, United States
Walter Reed National Military Medical Center
Status: Recruiting
Contact: Teresa A. York - 800-888-8823
Bethesda, Maryland, United States
Dana-Farber Cancer Institute
Status: Recruiting
Contact: Anne B. Warwick - 301-319-2100
Boston, Massachusetts, United States
Massachusetts General Hospital Cancer Center
Status: Recruiting
Contact: Carlos Rodriguez-Galindo - 866-790-4500
Boston, Massachusetts, United States
University of Massachusetts Medical School
Status: Recruiting
Contact: Carlos Rodriguez-Galindo - 866-790-4500
Worcester, Massachusetts, United States
C S Mott Children's Hospital
Status: Recruiting
Contact: Christopher P. Keuker - 508-856-3216 - cancer.research@umassmed.edu
Ann Arbor, Michigan, United States
Saint John Hospital and Medical Center
Status: Recruiting
Contact: Brenda J. Kitchen - 800-865-1125
Detroit, Michigan, United States
Wayne State University
Status: Recruiting
Contact: Hadi Sawaf - 313-343-3166
Detroit, Michigan, United States
Hurley Medical Center
Status: Recruiting
Contact: Roland L. Chu - 313-576-9363
Flint, Michigan, United States
Helen DeVos Children's Hospital at Spectrum Health
Status: Recruiting
Contact: Susumu Inoue - 888-606-6556
Grand Rapids, Michigan, United States
Bronson Methodist Hospital
Status: Recruiting
Contact: David S. Dickens - 616-267-1925
Kalamazoo, Michigan, United States
Michigan State University - Breslin Cancer Center
Status: Recruiting
Contact: Jeffrey S. Lobel - 800-227-2345
Lansing, Michigan, United States
Beaumont Children's Hospital-Royal Oak
Status: Recruiting
Contact: Renuka Gera - 517-334-2765
Royal Oak, Michigan, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis
Status: Terminated
Minneapolis, Minnesota, United States
University of Minnesota Medical Center-Fairview
Status: Recruiting
Contact: Bruce C. Bostrom - 612-813-5193
Minneapolis, Minnesota, United States
Mayo Clinic
Status: Recruiting
Contact: Brenda J. Weigel - 612-624-2620
Rochester, Minnesota, United States
University of Mississippi Medical Center
Status: Recruiting
Contact: Nadia N. Laack - 507-538-7623
Jackson, Mississippi, United States
Columbia Regional
Status: Recruiting
Contact: Gail C. Megason - 601-815-6700
Columbia, Missouri, United States
University of Missouri-Columbia
Status: Recruiting
Contact: Thomas W. Loew - 573-882-7440
Columbia, Missouri, United States
The Childrens Mercy Hospital
Status: Withdrawn
Kansas City, Missouri, United States
Saint John's Mercy Medical Center
Status: Recruiting
Contact: Maxine L. Hetherington - 816-234-3265
Saint Louis, Missouri, United States
Washington University School of Medicine
Status: Recruiting
Contact: Bethany G. Sleckman - 913-948-5588
Saint Louis, Missouri, United States
Children's Hospital and Medical Center of Omaha
Status: Recruiting
Contact: Frederick S. Huang - 800-600-3606 - info@siteman.wustl.edu
Omaha, Nebraska, United States
University of Nebraska Medical Center
Status: Recruiting
Contact: Minnie Abromowitch - 402-955-3949
Omaha, Nebraska, United States
Nevada Cancer Research Foundation CCOP
Status: Recruiting
Contact: Peter F. Coccia - 800-999-5465
Las Vegas, Nevada, United States
Dartmouth Hitchcock Medical Center
Status: Recruiting
Contact: Nik Farahana N. Rashid - 702-384-0013
Lebanon, New Hampshire, United States
Hackensack University Medical Center
Status: Recruiting
Contact: Sara Chaffee - 800-639-6918 - cancer.research.nurse@dartmouth.edu
Hackensack, New Jersey, United States
Saint Barnabas Medical Center
Status: Recruiting
Contact: Burton E. Appel - 201-996-2879
Livingston, New Jersey, United States
Morristown Memorial Hospital
Status: Recruiting
Contact: Stacey Rifkin-Zenenberg - 973-926-7230
Morristown, New Jersey, United States
Saint Peter's University Hospital
Status: Recruiting
Contact: Steven L. Halpern - 973-971-5900
New Brunswick, New Jersey, United States
UMDNJ - Robert Wood Johnson University Hospital
Status: Recruiting
Contact: Stanley Calderwood - 732-745-8600 - kcovert@saintpetersuh.com
New Brunswick, New Jersey, United States
Newark Beth Israel Medical Center
Status: Recruiting
Contact: Richard A. Drachtman - 732-235-8675
Newark, New Jersey, United States
Saint Joseph's Regional Medical Center
Status: Recruiting
Contact: Peri Kamalakar - 973-926-7230
Paterson, New Jersey, United States
Overlook Hospital
Status: Recruiting
Contact: Mary A. Bonilla - 973-754-2909
Summit, New Jersey, United States
University of New Mexico Cancer Center
Status: Recruiting
Contact: Steven L. Halpern - 973-971-5900
Albuquerque, New Mexico, United States
Albany Medical Center
Status: Recruiting
Contact: Koh B. Boayue - 505-272-6972
Albany, New York, United States
Montefiore Medical Center
Status: Recruiting
Contact: Vikramjit S. Kanwar - 518-262-3368
Bronx, New York, United States
Roswell Park Cancer Institute
Status: Recruiting
Contact: Rosanna J. Ricafort - 718-904-2730 - aecc@aecom.yu.edu
Buffalo, New York, United States
The Steven and Alexandra Cohen Children's Medical Center of New York
Status: Recruiting
Contact: Martin L. Brecher - 877-275-7724
New Hyde Park, New York, United States
Columbia University Medical Center
Status: Recruiting
Contact: Carolyn F. Levy - 718-470-3470
New York, New York, United States
Mount Sinai Medical Center
Status: Recruiting
Contact: Alice Lee - 212-305-8615
New York, New York, United States
New York University Langone Medical Center
Status: Recruiting
Contact: Birte Wistinghausen - 212-824-7320 - jenny.figueroa@mssm.edu
New York, New York, United States
University of Rochester
Status: Recruiting
Contact: Elizabeth A. Raetz - 212-263-4434 - prmc.coordinator@nyumc.org
Rochester, New York, United States
Stony Brook University Medical Center
Status: Recruiting
Contact: Lisa R. Hackney - 585-275-5830
Stony Brook, New York, United States
State University of New York Upstate Medical University
Status: Recruiting
Contact: Robert I. Parker - 800-862-2215
Syracuse, New York, United States
Ny Cancer%
Status: Recruiting
Contact: Karol H. Kerr - 315-464-5476
Valhalla, New York, United States
Mission Hospitals
Status: Recruiting
Contact: Mehmet F. Ozkaynak - 914-594-3794
Asheville, North Carolina, United States
University of North Carolina
Status: Recruiting
Contact: Krystal S. Bottom - 828-213-4150
Chapel Hill, North Carolina, United States
Carolinas Medical Center
Status: Recruiting
Contact: Stuart H. Gold - 877-668-0683 - cancerclinicaltrials@med.unc.edu
Charlotte, North Carolina, United States
Presbyterian Hospital
Status: Recruiting
Contact: Joel A. Kaplan - 704-355-2884
Charlotte, North Carolina, United States
Duke University Medical Center
Status: Recruiting
Contact: Paulette C. Bryant - 704-384-5369
Durham, North Carolina, United States
Wake Forest University Health Sciences
Status: Recruiting
Contact: Susan G. Kreissman - 888-275-3853
Winston-Salem, North Carolina, United States
Sanford Medical Center-Fargo
Status: Recruiting
Contact: Thomas W. McLean - 336-713-6771
Fargo, North Dakota, United States
Children's Hospital Medical Center of Akron
Status: Recruiting
Contact: Nathan L. Kobrinsky - 701-234-6161
Akron, Ohio, United States
Cincinnati Children's Hospital Medical Center
Status: Recruiting
Contact: Steven J. Kuerbitz - 330-543-3193
Cincinnati, Ohio, United States
Cleveland Clinic Foundation
Status: Recruiting
Contact: John P. Perentesis - 513-636-2799
Cleveland, Ohio, United States
Rainbow Babies and Childrens Hospital
Status: Recruiting
Contact: Margaret C. Thompson - 866-223-8100
Cleveland, Ohio, United States
Nationwide Children's Hospital
Status: Recruiting
Contact: Yousif (Joe) H. Matloub - 216-844-5437
Columbus, Ohio, United States
The Children's Medical Center of Dayton
Status: Recruiting
Contact: Mark A. Ranalli - 614-722-2708
Dayton, Ohio, United States
Mercy Children's Hospital
Status: Recruiting
Contact: Emmett H. Broxson - 800-228-4055
Toledo, Ohio, United States
The Toledo Hospital/Toledo Children's Hospital
Status: Recruiting
Contact: Rama Jasty - 419-251-8210
Toledo, Ohio, United States
University of Oklahoma Health Sciences Center
Status: Recruiting
Contact: Dagmar T. Stein - 419-824-1842
Oklahoma City, Oklahoma, United States
Natalie W Bryant Cancer Center
Status: Recruiting
Contact: Rene Y. McNall-Knapp - 405-271-4272 - julie-traylor@ouhsc.edu
Tulsa, Oklahoma, United States
Legacy Emanuel Children's Hospital
Status: Recruiting
Contact: Gregory B. Kirkpatrick - 918-494-2200
Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center
Status: Recruiting
Contact: Janice F. Olson - 503-413-2560
Portland, Oregon, United States
Oregon Health and Science University
Status: Recruiting
Contact: Janice F. Olson - 503-413-2560
Portland, Oregon, United States
Lehigh Valley Hospital - Muhlenberg
Status: Recruiting
Contact: Suman Malempati - 503-494-1080 - trials@ohsu.edu
Bethlehem, Pennsylvania, United States
Geisinger Medical Center
Status: Recruiting
Contact: Philip M. Monteleone - 484-884-2201
Danville, Pennsylvania, United States
Penn State Hershey Children's Hospital
Status: Recruiting
Contact: Jeffrey S. Taylor - 570-271-5251
Hershey, Pennsylvania, United States
Fox Chase Cancer Center
Status: Recruiting
Contact: Lisa M. McGregor - 717-531-6012
Philadelphia, Pennsylvania, United States
Saint Christopher's Hospital for Children
Status: Recruiting
Contact: Margaret von Mehren - 215-728-4790
Philadelphia, Pennsylvania, United States
Children's Hospital of Pittsburgh of UPMC
Status: Recruiting
Contact: Gregory E. Halligan - 215-427-8991
Pittsburgh, Pennsylvania, United States
Rhode Island Hospital
Status: Recruiting
Contact: Michael R. Wollman - 412-692-5573
Providence, Rhode Island, United States
Medical University of South Carolina
Status: Recruiting
Contact: Cindy L. Schwartz - 401-444-1488
Charleston, South Carolina, United States
Palmetto Health Richland
Status: Recruiting
Contact: Jacqueline M. Kraveka - 843-792-9321
Columbia, South Carolina, United States
BI-LO Charities Children's Cancer Center
Status: Recruiting
Contact: Ronnie W. Neuberg - 803-434-3680
Greenville, South Carolina, United States
Greenville Cancer Treatment Center
Status: Recruiting
Contact: Nichole L. Bryant - 864-241-6251
Greenville, South Carolina, United States
Sanford USD Medical Center - Sioux Falls
Status: Recruiting
Contact: Cary E. Stroud - 864-241-6251
Sioux Falls, South Dakota, United States
T C Thompson Children's Hospital
Status: Recruiting
Contact: Kayelyn J. Wagner - 605-328-1367
Chattanooga, Tennessee, United States
East Tennessee Childrens Hospital
Status: Recruiting
Contact: Donald H. Chamberlain - 423-698-2050
Knoxville, Tennessee, United States
St. Jude Children's Research Hospital
Status: Recruiting
Contact: Ray C. Pais - 865-541-8266
Memphis, Tennessee, United States
Vanderbilt-Ingram Cancer Center
Status: Recruiting
Contact: Wayne L. Furman - 901-595-4644
Nashville, Tennessee, United States
Dell Children's Medical Center of Central Texas
Status: Recruiting
Contact: Scott C. Borinstein - 800-811-8480
Austin, Texas, United States
Driscoll Children's Hospital
Status: Recruiting
Contact: Sharon K. Lockhart - 512-324-8022
Corpus Christi, Texas, United States
Medical City Dallas Hospital
Status: Recruiting
Contact: M. C. Johnson - 361-694-5311
Dallas, Texas, United States
University of Texas Southwestern Medical Center
Status: Recruiting
Contact: Carl Lenarsky - 972-566-5588
Dallas, Texas, United States
Brooke Army Medical Center
Status: Recruiting
Contact: Naomi J. Winick - 214-648-7097
Fort Sam Houston, Texas, United States
Cook Children's Medical Center
Status: Recruiting
Contact: Della L. Howell - 210-292-7311
Fort Worth, Texas, United States
Baylor College of Medicine
Status: Recruiting
Contact: Mary Meaghan P. Granger - 682-885-2103
Houston, Texas, United States
M D Anderson Cancer Center
Status: Recruiting
Contact: Lisa R. Bomgaars - 713-798-1354 - burton@bcm.edu
Houston, Texas, United States
M D Anderson Cancer Center
Status: Recruiting
Contact: Cynthia E. Herzog - cherzog@mdanderson.org
Houston, Texas, United States
Covenant Children's Hospital
Status: Recruiting
Contact: Najat C. Daw - 713-792-3245
Lubbock, Texas, United States
University of Texas Health Science Center at San Antonio
Status: Recruiting
Contact: Latha Prasannan - 806-725-8000 - jaccresearch@covhs.org
San Antonio, Texas, United States
Scott and White Memorial Hospital
Status: Recruiting
Contact: Anne-Marie R. Langevin - 210-567-0653 - che@uthscsa.edu
Temple, Texas, United States
Primary Children's Medical Center
Status: Recruiting
Contact: Guy H. Grayson - 254-724-5407
Salt Lake City, Utah, United States
University of Vermont
Status: Recruiting
Contact: Phillip E. Barnette - 801-585-5270
Burlington, Vermont, United States
University of Virginia
Status: Recruiting
Contact: Alan C. Homans - 802-656-8990
Charlottesville, Virginia, United States
Inova Fairfax Hospital
Status: Recruiting
Contact: Kimberly P. Dunsmore - 434-243-6143
Falls Church, Virginia, United States
Childrens Hospital-King's Daughters
Status: Recruiting
Contact: Marshall A. Schorin - 703-208-6650
Norfolk, Virginia, United States
Virginia Commonwealth University
Status: Recruiting
Contact: Eric J. Lowe - 757-668-7243
Richmond, Virginia, United States
Seattle Children's Hospital
Status: Recruiting
Contact: Kamar Godder - 305-662-8360
Seattle, Washington, United States
University of Washington Medical Center
Status: Recruiting
Contact: Douglas S. Hawkins - 866-987-2000
Seattle, Washington, United States
Providence Sacred Heart Medical Center and Children's Hospital
Status: Recruiting
Contact: Douglas S. Hawkins - 866-987-2000
Spokane, Washington, United States
Madigan Army Medical Center
Status: Recruiting
Contact: Judy L. Felgenhauer - 800-228-6618 - HopeBeginsHere@providence.org
Tacoma, Washington, United States
Mary Bridge Children's Hospital and Health Center
Status: Recruiting
Contact: Melissa A. Forouhar - 253-968-0129 - mamcdci@amedd.army.mil
Tacoma, Washington, United States
West Virginia University Charleston
Status: Recruiting
Contact: Robert G. Irwin - 888-823-5923 - ctsucontact@westat.com
Charleston, West Virginia, United States
University of Wisconsin Hospital and Clinics
Status: Recruiting
Contact: Allen R. Chauvenet - 304-388-9944
Madison, Wisconsin, United States
Marshfield Clinic
Status: Recruiting
Contact: Kenneth B. DeSantes - 608-262-5223
Marshfield, Wisconsin, United States
Froedtert and the Medical College of Wisconsin
Status: Recruiting
Contact: Michael J. McManus - 715-389-4457
Milwaukee, Wisconsin, United States
Midwest Children's Cancer Center
Status: Recruiting
Contact: Timothy S. Fenske - 414-805-4380
Milwaukee, Wisconsin, United States
Sydney Children's Hospital
Status: Recruiting
Contact: Meghen B. Browning - 414-805-4380
Randwick, New South Wales, Australia
The Children's Hospital at Westmead
Status: Recruiting
Contact: Draga Barbaric - (02) 9382-1721
Sydney, New South Wales, Australia
Royal Brisbane and Women's Hospital
Status: Recruiting
Contact: Geoffrey B. McCowage - 61-2-9845 1400
Herston, Queensland, Australia
Royal Childrens Hospital
Status: Recruiting
Contact: Helen Irving - 888-823-5923 - ctsucontact@westat.com
Herston, Queensland, Australia
Women's and Children's Hospital-Adelaide
Status: Recruiting
Contact: Helen Irving - 888-823-5923 - ctsucontact@westat.com
North Adelaide, South Australia, Australia
Princess Margaret Hospital for Children
Status: Recruiting
Contact: Maria L. Kirby - (08) 8161 7327 - cywhs.oncsec@health.sa.gov.au
Perth, Western Australia, Australia
Alberta Children's Hospital
Status: Recruiting
Contact: Catherine H. Cole - (08) 9340 8330 - admin@childcancerresearch.com.au
Calgary, Alberta, Canada
British Columbia Children's Hospital
Status: Recruiting
Contact: Douglas R. Strother - 403-220-6898 - research4kids@ucalgary.ca
Vancouver, British Columbia, Canada
CancerCare Manitoba
Status: Recruiting
Contact: Caron Strahlendorf - 604-875-2345ext6477
Winnipeg, Manitoba, Canada
Janeway Child Health Centre
Status: Recruiting
Contact: Rochelle A. Yanofsky - 866-561-1026 - CIO_Web@cancercare.mb.ca
Saint John's, Newfoundland and Labrador, Canada
IWK Health Centre
Status: Recruiting
Contact: Lisa Anne B. Goodyear - 866-722-1126
Halifax, Nova Scotia, Canada
Chedoke-McMaster Hospitals
Status: Recruiting
Contact: Margaret C. Yhap - 902-470-8394
Hamilton, Ontario, Canada
McMaster Children's Hospital at Hamilton Health Sciences
Status: Recruiting
Contact: Carol Portwine - 905-521-2100ext74595
Hamilton, Ontario, Canada
Cancer Centre of Southeastern Ontario at Kingston General Hospital
Status: Recruiting
Contact: Carol Portwine - 905-521-2100ext74595
Kingston, Ontario, Canada
Children's Hospital
Status: Recruiting
Contact: Mariana P. Silva - 613-544-2630
London, Ontario, Canada
Children's Hospital of Eastern Ontario
Status: Recruiting
Contact: Anne E. Cairney - 519-685-8306
Ottawa, Ontario, Canada
Hospital for Sick Children
Status: Recruiting
Contact: Jacqueline M. Halton - 613-738-3931
Toronto, Ontario, Canada
Centre Hospitalier Universitaire Sainte-Justine
Status: Recruiting
Contact: Abha A. Gupta - 416-946-4501 - clinical.trials@uhn.on.ca
Montreal, Quebec, Canada
The Montreal Children's Hospital of the MUHC
Status: Recruiting
Contact: Yvan Samson - 514-345-4931
Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Quebec
Status: Recruiting
Contact: Sharon B. Abish - 514-412-4445 - info@thechildren.com
Ste-Foy, Quebec, Canada
Allan Blair Cancer Centre
Status: Recruiting
Contact: Bruno Michon - 418-525-4444
Regina, Saskatchewan, Canada
Saskatoon Cancer Centre
Status: Recruiting
Contact: Mansoor M. Haq - 306-766-2213
Saskatoon, Saskatchewan, Canada
Starship Children's Hospital
Status: Recruiting
Contact: Christopher Mpofu - 306-655-2914
Grafton, Auckland, New Zealand
Christchurch Hospital
Status: Recruiting
Contact: Lochie R. Teague - 0800 728 436
Christchurch, New Zealand
San Jorge Children's Hospital
Status: Recruiting
Contact: Siobhan F. Cross - 03 364 0640
Santurce, Puerto Rico
Status: Recruiting
Contact: Luis A. Clavell - 888-823-5923 - ctsucontact@westat.com
Start Date
November 2010
Sponsors
Children's Oncology Group
Source
Children's Oncology Group
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page