Retrospective Study of Ovarian Cancer Patients With Brain Metastasis
Ovarian Cancer - Brain Metastases
Conditions: official terms
Brain Neoplasms - Neoplasm Metastasis - Ovarian Neoplasms
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Retrospective
Overall Status
Ovarian cancer, especially epithelial ovarian carcinoma, has the highest mortality rate among the gynecologic malignancies. The majority of patients with epithelial ovarian carcinoma are diagnosed at advanced stage which has the overall survival rates of only 19-30%. As the advance in the managements which prolonged the overall survival, metastatic lesion in rare location such as brain was noted in few patients of ovarian cancer in recent years. In the retrospective study, the investigators will review the medical records of the ovarian cancer patients with brain metastasis in the investigators hospital to investigate the incidence, clinical courses, optimal managements and possible prognostic factors in the rare condition.
Detailed Description
The ovarian cancer patient treated at the Department of Obstetrics and Gynecology of the National Taiwan University Hospital were retrospectively collected. The cancer registration database was searched for the patients with ovarian carcinoma who brain metastases were also diagnosed. The medical records of these patients were reviewed with particular attention to the results of histo-pathological and radiologic reports. Patients with other synchronous primary brain tumor were excluded. The initial management of primary tumor, including the surgery and adjuvant chemotherapy, and the clinical courses and disease status, such as remission, recurrence and progression, were all carefully reviewed. The intra-cranial lesions were all diagnosed by imaging studies, including brain computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therapeutic strategies for the metastatic lesions in the brain were also reviewed. All statistical analyses were performed using the SPSS 13.0 statistical software for Windows. P<0.05 was defined as statistical significance. Survival was measured from the time of initial diagnosis of brain metastasis until the date of death or last contact, and was presented by Kaplan-Meier curves.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 80 Years
Minimum Age: 25 Years
Gender: Female
Criteria: Inclusion Criteria:

- Patients with ovarian cancer and brain metastasis

- Patients ovarian cancer from National Taiwan University Hospital

Exclusion Criteria:

- none
National Taiwan University Hospital
Taipei, Taiwan
Status: Recruiting
Contact: Wen-Fang Cheng, Professor - 886-2-23123456 -
Start Date
April 2010
Completion Date
December 2011
National Taiwan University Hospital
National Taiwan University Hospital
Record processing date processed this data on July 28, 2015 page