The Development of Diagnostic Biomarker Panels for Hepatitis and Liver Cancer
Hepatitis B,Chronic - Carcinoma,Hepatocellular
Conditions: official terms
Carcinoma, Hepatocellular - Hepatitis - Hepatitis A - Hepatitis B, Chronic
Conditions: Keywords
hepatocellular carcinoma, microarray, gene expression profiling, biomarkers
Study Type
Study Phase
Study Design
Time Perspective: Cross-Sectional
Overall Status
More recent studies have shown that the HBV-infected population has a greater risk of development of hepatocellular carcinoma. Nevertheless, there are still a significant number of people chronically infected by HBV who do not develop the complication. Hence, there exist biological markers that could be indicator for the disease-inducing and carcinogenic potential of the virus.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 21 Years
Gender: Both
Criteria: Inclusion Criteria:

- Patients of at least 21 years old on day of giving consent for study

- Patients must be able and wiling to give an informed consent

- Patient with chronic HBV infection

- Patient with active hepatocellular carcinoma and chronic hepatitis B

- Healthy subjects

Exclusion Criteria:

- Patients who have co-infection with HIV or chronic hepatitis C

- Subjects with other types of cancer
Sultanah Bahiyah Hospital
Alor Star, Kedah, Malaysia
Status: Recruiting
Queen Elizabeth Hospital
Kota Kinabalu, Sabah, Malaysia
Status: Recruiting
Hospital Umum Kuching Sarawak
Kuching, Sarawak, Malaysia
Status: Not yet recruiting
Selayang Hospital
Selayang, Selangor, Malaysia
Status: Recruiting
Kuala Lumpur Hospital
Kuala Lumpur, Wilayah Persekutuan, Malaysia
Status: Not yet recruiting
Island Hospital
Pulau Pinang, Malaysia
Status: Not yet recruiting
Lam Wah Ee Hospital
Pulau Pinang, Malaysia
Status: Recruiting
Penang Hospital
Pulau Pinang, Malaysia
Status: Recruiting
Start Date
August 2010
Completion Date
August 2012
Ministry of Health, Malaysia
Ministry of Health, Malaysia
Record processing date processed this data on July 28, 2015 page