Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
Conditions
Papillary Thyroid Microcarcinoma
Conditions: official terms
Carcinoma, Papillary - Thyroid Diseases - Thyroid Neoplasms
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Overall Status
Recruiting
Summary
In this study, the investigators look at the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.
Detailed Description
Papillary thyroid carcinomas (PTCs) measuring 1.0 cm or less in diameter were defined as papillary thyroid microcarcinomas (PTMCs) by the World Health Organization (WHO), emphasizing on their benign behavior, probably of little clinical significance, which do not affect patients' survival. However, some reported that PTMCs may have aggressive behavior, can cause locoregional recurrences, cervical lymph node metastases, and even distant metastases. But till now, the characteristics of PTMCs with early lateral neck node metastasis were only reviewed and described by the clinicopathological parameters, and no analysis of PTMCs by the gene level is available. In these study, we investigate the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 20 Years
Gender: Both
Criteria: Inclusion Criteria:

- age≥20 years old

- Conventional type papillary thyroid microcarcinoma (0.5cm≤tumor size≤1.0cm)

- group 1: no lymph node metastasis /group 2: with lateral neck node metastasis

Exclusion Criteria:

- tumor with capsular invasion (T3 tumor)

- distant metastasis

- combined underlying thyroiditis
Location
Severance Hospital
Seoul, Korea, Republic of
Status: Recruiting
Contact: Woung-Youn Chung, MD, Ph.D - 82-2-2228-2100 - woungyounc@yuhs.ac
Start Date
June 2011
Completion Date
December 2013
Sponsors
Yonsei University
Source
Yonsei University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page