Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer
Conditions
Cervical Adenocarcinoma - Cervical Adenosquamous Carcinoma - Cervical Squamous Cell Carcinoma - Chemotherapeutic Agent Toxicity - Cognitive Side Effects of Cancer Therapy - Psychological Impact of Cancer - Radiation Toxicity - Sexual Dysfunction and Infertility - Stage IB Cervical Cancer - Stage IIA Cervical Cancer - Stage IIB Cervical Cancer - Stage III Cervical Cancer - Stage IVA Cervical Cancer
Conditions: official terms
Adenocarcinoma - Carcinoma - Carcinoma, Adenosquamous - Carcinoma, Squamous Cell - Uterine Cervical Neoplasms
Study Type
Interventional
Study Phase
Phase 3
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Carboplatin Type: Drug
Name: Cisplatin Type: Drug
Name: External Beam Radiation Therapy Type: Radiation
Name: Internal Radiation Therapy Type: Radiation
Name: Paclitaxel Type: Drug
Name: Quality-of-Life Assessment Type: Other
Overall Status
Recruiting
Summary
This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with locally advanced cervical cancer. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.
Detailed Description
PRIMARY OBJECTIVES:

I. To determine if the addition of adjuvant chemotherapy to standard cisplatin-based chemoradiation improves overall survival.

SECONDARY OBJECTIVES:

I. To determine the progression-free survival rates. II. To determine acute and long-term toxicities. III. To determine patterns of disease recurrence. IV. To determine the association between radiation protocol compliance and outcomes.

V. To determine patient quality of life, including psycho-sexual health.

TERTIARY OBJECTIVES:

I. To determine the association between the results of a follow-up positron emission tomography (PET) scan performed 4-6 months post completion of chemoradiation and outcomes for all patients in the trial.

II. To determine the biological predictors of patients' outcomes based on translational laboratory studies of blood and tissue specimens.

OUTLINE: This is a multicenter study. Patients are stratified according to pelvic or common iliac nodal involvement (yes vs no), requirement for extended-field radiotherapy treatment (yes vs no), International Federation of Gynecology and Obstetrics (FIGO) stage (IB/IIA vs IIB vs IIIB/IVA), age (< 60 years of age vs >= 60 years of age), and hospital/site. Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive cisplatin intravenously (IV) over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.

ARM II: Patients receive cisplatin and undergo external-beam radiation and brachytherapy as in arm I. Beginning 4 weeks later, patients also receive adjuvant chemotherapy comprising paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Patients may undergo baseline tumor biopsy and blood collection for future correlative studies.

Patients complete the European Organization for Research and Treatment of Cancer (EORTC) Core questionnaire (QLQ-C30), the EORTC cervix cancer module (CX24), the ovarian cancer module (OV28), and the Sexual function-Vaginal Changes Questionnaire (SVQ) questionnaires at baseline, during, and after completion of study treatment.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- Eligible patients will have locally advanced cervical cancer suitable for primary treatment with chemoradiation with curative intent, in addition to:

- Histological diagnosis of squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma of the cervix

- FIGO 2008 stage IB1 & node positive, IB2, II, IIIB, or IVA disease

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Histological diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous cell carcinoma of the cervix

- White blood cells (WBC) >= 3.0 x 10^9/L

- Absolute neutrophil count (ANC) >= 1.5 x 10^9/L

- Platelet count >= 100 x 10^9/L

- Bilirubin =< 1.5 times upper limit of normal (ULN)

- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x ULN

- Creatinine =< ULN (Common Toxicity Criteria [CTC] Grade 0) OR calculated creatinine clearance (Cockcroft-Gault Formula) >= 60 mL/min OR >= 50 mL/min by ethylenediaminetetraacetic acid (EDTA) creatinine clearance

- Written informed consent

Exclusion Criteria:

- Any previous pelvic radiotherapy

- Para-aortic nodal involvement above the level of the common iliac nodes or L3/L4 (if biopsy proven, PET positive, or >= 15 mm short-axis diameter on computed tomography [CT])

- FIGO 2008 stage IIIA disease

- Patients assessed at presentation as requiring interstitial brachytherapy treatment

- Patients with bilateral hydronephrosis unless at least one side has been stented and renal function fulfills the required inclusion criteria

- Previous chemotherapy for this tumor

- Evidence of distant metastases

- Prior diagnosis of Crohn disease or ulcerative colitis

- Peripheral neuropathy >= grade 2 (per Common Terminology Criteria for Adverse Events [CTCAE] v. 4)

- Patients who have undergone a previous hysterectomy or will have a hysterectomy as part of their initial cervical cancer therapy

- Patients with other invasive malignancies, with the exception of non-melanoma skin cancer and in situ melanoma, who had (or have) any evidence of the other cancer present within the last 5 years

- Patients who are pregnant or lactating

- Any contraindication to the use of cisplatin, carboplatin, or paclitaxel chemotherapy

- Serious illness or medical condition that precludes the safe administration of the trial treatment including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

- Human immunodeficiency virus (HIV) positive
Locations
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Status: Recruiting
Contact: Warner K. Huh - 205-934-0309
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, United States
Status: Recruiting
Contact: Rodney P. Rocconi - 251-445-9870 - pfrancisco@usouthal.edu
Alaska Women's Cancer Care
Anchorage, Alaska, United States
Status: Recruiting
Contact: Matthew C. Solhjem - 503-215-6412 - Julie.Cramer@providence.org
Providence Alaska Medical Center
Anchorage, Alaska, United States
Status: Recruiting
Contact: Matthew C. Solhjem - 503-215-6412 - Julie.Cramer@providence.org
Arizona Oncology Associates-Biltmore Cancer Center
Phoenix, Arizona, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
Gynecologic Oncology Group of Arizona
Phoenix, Arizona, United States
Status: Recruiting
Contact: Kathleen N. Moore - 405-271-8707 - lreese@gog.org
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
Status: Recruiting
Contact: John H. Farley - 301-319-2100
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Status: Recruiting
Contact: Kristin K. Zorn - 501-686-8274
John Muir Medical Center-Concord Campus
Concord, California, United States
Status: Recruiting
Contact: Babak Edraki - 925-674-2580
Kaiser Permanente, Fremont
Fremont, California, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, United States
Status: Recruiting
Contact: John K. Chan - 415-209-2686 - bernicl@sutterhealth.org
Kaiser Permanente-Oakland
Oakland, California, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
Saint Joseph Hospital - Orange
Orange, California, United States
Status: Recruiting
Contact: Michael L. Berman - 877-827-8839 - ucstudy@uci.edu
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, United States
Status: Recruiting
Contact: Krishnansu S. Tewari - 714-456-6191 - awallick@uci.edu
Kaiser Permanente-Roseville
Roseville, California, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Status: Recruiting
Contact: Gary S. Leiserowitz - 916-734-3089
Kaiser Permanente-San Francisco
San Francisco, California, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
Olive View-University of California Los Angeles Medical Center
Sylmar, California, United States
Status: Recruiting
Contact: Christine H. Holschneider - 888-798-0719
Kaiser Permanente-Vallejo
Vallejo, California, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
John Muir Medical Center-Walnut Creek
Walnut Creek, California, United States
Status: Recruiting
Contact: Babak Edraki - 925-674-2580
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
The Medical Center of Aurora
Aurora, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
University of Colorado Cancer Center - Anschutz Cancer Pavilion
Aurora, Colorado, United States
Status: Recruiting
Contact: Saketh R. Guntupalli - 720-848-0650
Boulder Community Hospital
Boulder, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
Status: Active, not recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Colorado Blood Cancer Institute
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Colorado Cancer Research Program CCOP
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Exempla Saint Joseph Hospital
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Porter Adventist Hospital
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rose Medical Center
Denver, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Southwest Oncology PC
Durango, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Swedish Medical Center
Englewood, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
North Colorado Medical Center
Greeley, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Greenwood Village
Greenwood Village, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Saint Anthony Hospital
Lakewood, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Littleton Adventist Hospital
Littleton, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Sky Ridge Medical Center
Lone Tree, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Longmont United Hospital
Longmont, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
McKee Medical Center
Loveland, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Parker Adventist Hospital
Parker, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Parker
Parker, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers - Pueblo
Pueblo, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Saint Mary Corwin Medical Center
Pueblo, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
University of Connecticut
Farmington, Connecticut, United States
Status: Active, not recruiting
Hartford Hospital
Hartford, Connecticut, United States
Status: Recruiting
Contact: James S. Hoffman - 860-224-5660
The Hospital of Central Connecticut
New Britain, Connecticut, United States
Status: Recruiting
Contact: James S. Hoffman - 860-224-5660
Yale University
New Haven, Connecticut, United States
Status: Active, not recruiting
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Status: Active, not recruiting
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Status: Recruiting
Contact: Aaron H. Wolfson - 866-574-5124 - Sylvester@emergingmed.com
Jackson Memorial Hospital-Holtz Children's Hospital
Miami, Florida, United States
Status: Recruiting
Contact: Aaron H. Wolfson - 866-574-5124 - Sylvester@emergingmed.com
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Status: Recruiting
Contact: Aaron H. Wolfson - 866-574-5124 - Sylvester@emergingmed.com
UF Cancer Center at Orlando Health
Orlando, Florida, United States
Status: Recruiting
Contact: Kathleen N. Moore - 405-271-4272 - julie-traylor@ouhsc.edu
Sarasota Memorial Hospital
Sarasota, Florida, United States
Status: Active, not recruiting
Emory University/Winship Cancer Institute
Atlanta, Georgia, United States
Status: Active, not recruiting
Grady Health System
Atlanta, Georgia, United States
Status: Active, not recruiting
Northside Hospital
Atlanta, Georgia, United States
Status: Recruiting
Contact: Sahar E. Rosenbaum - 404-303-3355
Northeast Georgia Medical Center
Gainesville, Georgia, United States
Status: Recruiting
Contact: Andrew E. Green - 770-219-8800 - cancerpatient.navigator@nghs.com
Central Georgia Gynecologic Oncology
Macon, Georgia, United States
Status: Withdrawn
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, United States
Status: Recruiting
Contact: Tatjana Kolevska - 626-564-3455
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States
Status: Recruiting
Contact: Michael E. Carney - 808-983-6090
Queen's Medical Center
Honolulu, Hawaii, United States
Status: Recruiting
Contact: Michael E. Carney - 808-983-6090
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Status: Recruiting
Contact: Michael E. Carney - 808-983-6090
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Saint Joseph Medical Center
Bloomington, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Canton
Canton, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Carthage
Carthage, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Status: Recruiting
Contact: Thomas E. Lad - 312-864-6000
Northwestern University
Chicago, Illinois, United States
Status: Recruiting
Contact: Eric D. Donnelly - 312-695-1301 - cancer@northwestern.edu
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Status: Recruiting
Contact: Meaghan E. Tenney - 773-834-7424
Illinois CancerCare-Eureka
Eureka, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, United States
Status: Active, not recruiting
Illinois CancerCare Galesburg
Galesburg, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Western Illinois Cancer Treatment Center
Galesburg, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Sudarshan K Sharma MD Limted-Gynecologic Oncology
Hinsdale, Illinois, United States
Status: Recruiting
Contact: Sudarshan K. Sharma - 630-856-6757
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Macomb
Macomb, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Loyola University Medical Center
Maywood, Illinois, United States
Status: Recruiting
Contact: William Small - 708-226-4357
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Pekin Cancer Treatment Center
Pekin, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 800-793-2262
Illinois CancerCare-Peoria
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 800-793-2262
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 800-793-2262
OSF Saint Francis Medical Center
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 800-793-2262
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
Peoria, Illinois, United States
Status: Recruiting
Contact: Nguyet A. Le-Lindqwister - 800-793-2262
Illinois CancerCare-Peru
Peru, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Valley Radiation Oncology
Peru, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Illinois CancerCare-Princeton
Princeton, Illinois, United States
Status: Recruiting
Contact: James L. Wade - 217-876-4740 - kcheek@dmhhs.org
Michiana Hematology Oncology PC-Elkhart
Elkhart, Indiana, United States
Status: Recruiting
Contact: Kathleen N. Moore - 405-271-4272 - julie-traylor@ouhsc.edu
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States
Status: Active, not recruiting
Saint Vincent Oncology Center
Indianapolis, Indiana, United States
Status: Recruiting
Contact: Michael J. Callahan - 317-338-2194 - research@stvincent.org
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka, Indiana, United States
Status: Recruiting
Contact: Kathleen N. Moore - 405-271-4272 - julie-traylor@ouhsc.edu
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States
Status: Recruiting
Contact: David P. Bender - 800-237-1225
University of Kansas Cancer Center
Kansas City, Kansas, United States
Status: Recruiting
Contact: Julia A. Chapman - 913-945-7552 - ctnursenav@kumc.edu
Baptist Health Lexington
Lexington, Kentucky, United States
Status: Recruiting
Contact: Hope M. Cottrill - 859-260-6425
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States
Status: Recruiting
Contact: Frederick R. Ueland - 859-257-3379
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, United States
Status: Active, not recruiting
Louisiana State University Health Science Center
New Orleans, Louisiana, United States
Status: Recruiting
Contact: Augusto C. Ochoa - 504-568-2428 - emede1@lsuhsc.edu
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Status: Recruiting
Contact: Richard C. Kline - 888-562-4763
Tulane University Health Sciences Center
New Orleans, Louisiana, United States
Status: Recruiting
Contact: William R. Robinson - 504-988-6121
Maine Medical Center-Bramhall Campus
Portland, Maine, United States
Status: Terminated
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States
Status: Recruiting
Contact: Gautam G. Rao - 800-888-8823
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Status: Recruiting
Contact: Michael P. Stany - 301-319-2100
Baystate Medical Center
Springfield, Massachusetts, United States
Status: Active, not recruiting
University of Massachusetts Memorial Health Care
Worcester, Massachusetts, United States
Status: Active, not recruiting
Bronson Battle Creek
Battle Creek, Michigan, United States
Status: Recruiting
Contact: Gilbert D. Padula - 616-685-5225 - connie.szczepanek@grcop.org
Henry Ford Hospital
Detroit, Michigan, United States
Status: Recruiting
Contact: Thomas E. Buekers - 313-916-1784
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States
Status: Recruiting
Contact: Robert T. Morris - 313-576-9363
Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, United States
Status: Terminated
Mercy Health Saint Mary's
Grand Rapids, Michigan, United States
Status: Recruiting
Contact: Gilbert D. Padula - 616-685-5225 - connie.szczepanek@grcop.org
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, United States
Status: Recruiting
Contact: Gilbert D. Padula - 616-685-5225 - connie.szczepanek@grcop.org
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Status: Recruiting
Contact: Sunil Nagpal - 269-373-7458
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States
Status: Recruiting
Contact: Jayson B. Field - 248-551-7695
Munson Medical Center
Traverse City, Michigan, United States
Status: Recruiting
Contact: Gilbert D. Padula - 616-685-5225 - connie.szczepanek@grcop.org
Mercy Hospital
Coon Rapids, Minnesota, United States
Status: Withdrawn
Fairview-Southdale Hospital
Edina, Minnesota, United States
Status: Withdrawn
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States
Status: Withdrawn
University of Minnesota Medical Center-Fairview
Minneapolis, Minnesota, United States
Status: Recruiting
Contact: Peter A. Argenta - 612-624-2620
United Hospital
Saint Paul, Minnesota, United States
Status: Withdrawn
Minnesota Oncology and Hematology PA-Woodbury
Woodbury, Minnesota, United States
Status: Recruiting
Contact: Matthew P. Boente - 952-993-1517 - MMCCOP@parknicollet.com
University of Mississippi Medical Center
Jackson, Mississippi, United States
Status: Recruiting
Contact: James T. Thigpen - 601-815-6700
CoxHealth South Hospital
Springfield, Missouri, United States
Status: Recruiting
Contact: Jay W. Carlson - 800-821-7532
Mercy Hospital Springfield
Springfield, Missouri, United States
Status: Recruiting
Contact: Jay W. Carlson - 800-821-7532
Billings Clinic Cancer Center
Billings, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint Vincent Healthcare
Billings, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Bozeman Deaconess Hospital
Bozeman, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint Peter's Community Hospital
Helena, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Kalispell Regional Medical Center
Kalispell, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Saint Patrick Hospital - Community Hospital
Missoula, Montana, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Nebraska Methodist Hospital
Omaha, Nebraska, United States
Status: Recruiting
Contact: Peter C. Morris - 402-354-7939 - kathryn.bartz@nmhs.org
University of Nebraska Medical Center
Omaha, Nebraska, United States
Status: Active, not recruiting
Women's Cancer Center of Nevada
Las Vegas, Nevada, United States
Status: Recruiting
Contact: Nicola M. Spirtos - 702-851-4672
Wentworth-Douglass Hospital
Dover, New Hampshire, United States
Status: Recruiting
Contact: John O. Schorge - 877-726-5130
Cooper Hospital University Medical Center
Camden, New Jersey, United States
Status: Recruiting
Contact: David P. Warshal - 856-325-6757
Hackensack University Medical Center
Hackensack, New Jersey, United States
Status: Recruiting
Contact: Donna T. McNamara - 201-996-2879
Morristown Medical Center
Morristown, New Jersey, United States
Status: Recruiting
Contact: Yana P. Goldberg - 973-971-5900
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
Mount Holly, New Jersey, United States
Status: Withdrawn
Jersey Shore Medical Center
Neptune, New Jersey, United States
Status: Recruiting
Contact: Karim S. ElSahwi - 732-776-4240
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Status: Recruiting
Contact: Darlene G. Gibbon - 732-235-8675
Southwest Gynecologic Oncology Associates Inc
Albuquerque, New Mexico, United States
Status: Recruiting
Contact: Teresa L. Rutledge - 505-272-6972
University of New Mexico
Albuquerque, New Mexico, United States
Status: Recruiting
Contact: Kathleen N. Moore - 405-271-4272 - julie-traylor@ouhsc.edu
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States
Status: Recruiting
Contact: Teresa L. Rutledge - 505-272-6972
Women's Cancer Care Associates LLC
Albany, New York, United States
Status: Active, not recruiting
Montefiore Medical Center-Einstein Campus
Bronx, New York, United States
Status: Active, not recruiting
State University of New York Downstate Medical Center
Brooklyn, New York, United States
Status: Active, not recruiting
The New York Methodist Hospital
Brooklyn, New York, United States
Status: Recruiting
Contact: Katherine Economos - 718-780-5240
Roswell Park Cancer Institute
Buffalo, New York, United States
Status: Recruiting
Contact: Peter J. Frederick - 877-275-7724
New York Hospital Medical Center of Queens
Fresh Meadows, New York, United States
Status: Terminated
Queens Hospital Center
Jamaica, New York, United States
Status: Terminated
North Shore University Hospital
Manhasset, New York, United States
Status: Recruiting
Contact: Veena S. John - 516-562-3467
Winthrop University Hospital
Mineola, New York, United States
Status: Recruiting
Contact: Eva Chalas - 866-946-8476
Long Island Jewish Medical Center
New Hyde Park, New York, United States
Status: Recruiting
Contact: Veena S. John - 516-562-3467
North Shore-LIJ Health System/Center for Advanced Medicine
New Hyde Park, New York, United States
Status: Recruiting
Contact: Veena S. John - 516-562-3467
Laura and Issac Perlmutter Cancer Center at NYU Langone
New York, New York, United States
Status: Recruiting
Contact: Stephanie V. Blank - 212-263-4434 - prmc.coordinator@nyumc.org
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Status: Recruiting
Contact: Mario M. Leitao - 212-639-7202
Stony Brook University Medical Center
Stony Brook, New York, United States
Status: Recruiting
Contact: Michael L. Pearl - 800-862-2215
Memorial Sloan-Kettering Cancer Center West Harrison
West Harrison, New York, United States
Status: Recruiting
Contact: Mario M. Leitao - 212-639-7202
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina, United States
Status: Recruiting
Contact: Janak K. Choksi - 336-538-7725
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Status: Active, not recruiting
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, United States
Status: Recruiting
Contact: Robert V. Higgins - 704-355-2884
Carolinas HealthCare System NorthEast
Concord, North Carolina, United States
Status: Recruiting
Contact: Robert V. Higgins - 704-355-2884
New Hanover Regional Medical Center/Zimmer Cancer Center
Wilmington, North Carolina, United States
Status: Withdrawn
Southeast Cancer Consortium-Upstate NCORP
Winston-Salem, North Carolina, United States
Status: Terminated
Summa Akron City Hospital/Cooper Cancer Center
Akron, Ohio, United States
Status: Recruiting
Contact: Vivian E. von Gruenigen - 330-375-6101
University of Cincinnati
Cincinnati, Ohio, United States
Status: Active, not recruiting
Case Western Reserve University
Cleveland, Ohio, United States
Status: Withdrawn
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, United States
Status: Recruiting
Contact: Peter G. Rose - 866-223-8100
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Status: Recruiting
Contact: Peter G. Rose - 866-223-8100
MetroHealth Medical Center
Cleveland, Ohio, United States
Status: Recruiting
Contact: Peter G. Rose - 866-223-8100
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Status: Recruiting
Contact: David M. O'Malley - 800-293-5066 - Jamesline@osumc.edu
Riverside Methodist Hospital
Columbus, Ohio, United States
Status: Recruiting
Contact: John P. Kuebler - 614-488-2745 - sheree@columbusccop.org
Miami Valley Hospital
Dayton, Ohio, United States
Status: Recruiting
Contact: Howard M. Gross - 937-775-1350
Kettering Medical Center
Kettering, Ohio, United States
Status: Recruiting
Contact: Howard M. Gross - 937-775-1350
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, United States
Status: Recruiting
Contact: Peter G. Rose - 866-223-8100
Lake University Ireland Cancer Center
Mentor, Ohio, United States
Status: Withdrawn
University of Toledo
Toledo, Ohio, United States
Status: Withdrawn
Wright-Patterson Medical Center
Wright-Patterson Afb, Ohio, United States
Status: Active, not recruiting
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Status: Recruiting
Contact: Robert S. Mannel - 405-271-4272 - julie-traylor@ouhsc.edu
Tulsa Cancer Institute
Tulsa, Oklahoma, United States
Status: Recruiting
Contact: Robert S. Mannel - 405-271-4272 - julie-traylor@ouhsc.edu
Providence Portland Medical Center
Portland, Oregon, United States
Status: Recruiting
Contact: Matthew C. Solhjem - 503-215-6412 - Julie.Cramer@providence.org
Abington Memorial Hospital
Abington, Pennsylvania, United States
Status: Recruiting
Contact: Parviz Hanjani - 215-481-2402
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, United States
Status: Recruiting
Contact: Nicholas P. Taylor - 610-954-3582 - infolink@slhn.org
Drexel University School of Medicine
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Scott D. Richard - 866-884-4484
Gynecologic Oncology Group
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Philip J. DiSaia - 215-854-0770 - lreese@gog.org
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Status: Recruiting
Contact: Pramila R. Anne - 215-955-6084
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, United States
Status: Active, not recruiting
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania, United States
Status: Recruiting
Contact: Dwight E. Heron - 412-647-8073
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, United States
Status: Recruiting
Contact: Dwight E. Heron - 412-647-8073
Reading Hospital
West Reading, Pennsylvania, United States
Status: Recruiting
Contact: Bernice L. Robinson-Bennett - 610-988-9323
Women and Infants Hospital
Providence, Rhode Island, United States
Status: Recruiting
Contact: Paul A. DiSilvestro - 401-274-1122
AnMed Health Cancer Center
Anderson, South Carolina, United States
Status: Recruiting
Contact: David Griffin - 864-512-1000
Medical University of South Carolina
Charleston, South Carolina, United States
Status: Recruiting
Contact: Jennifer L. Young Pierce - 843-792-9321
Saint Francis Hospital
Greenville, South Carolina, United States
Status: Recruiting
Contact: David Griffin - 864-512-1000
Spartanburg Medical Center
Spartanburg, South Carolina, United States
Status: Recruiting
Contact: David Griffin - 864-512-1000
Black Hills Obstetrics and Gynecology
Rapid City, South Dakota, United States
Status: Recruiting
Contact: Helen L. Frederickson - 605-343-9224
Rapid City Regional Hospital
Rapid City, South Dakota, United States
Status: Recruiting
Contact: Helen L. Frederickson - 605-343-9224
Texas Oncology - Central Austin Cancer Center
Austin, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
Texas Oncology - South Austin Cancer Center
Austin, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
Texas Oncology-Austin Midtown
Austin, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
Texas Oncology Bedford
Bedford, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
Texas Oncology at Baylor Charles A Sammons Cancer Center
Dallas, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States
Status: Recruiting
Contact: David S. Miller - 214-648-7097
Texas Oncology Fort Worth at 12th Avenue
Fort Worth, Texas, United States
Status: Recruiting
Contact: Michael A. Bookman - 520-626-9008
University of Texas Medical Branch
Galveston, Texas, United States
Status: Active, not recruiting
Lyndon Baines Johnson General Hospital
Houston, Texas, United States
Status: Recruiting
Contact: Lois M. Ramondetta - 713-792-3245
M D Anderson Cancer Center
Houston, Texas, United States
Status: Recruiting
Contact: Lois M. Ramondetta - 713-792-3245
M D Anderson Cancer Center
Houston, Texas, United States
Status: Recruiting
Contact: Lois M. Ramondetta - lramonde@mdanderson.org
Memorial Hermann Texas Medical Center
Houston, Texas, United States
Status: Active, not recruiting
The Methodist Hospital System
Houston, Texas, United States
Status: Recruiting
Contact: Aparna A. Kamat - 713-790-2700
Intermountain Medical Center
Murray, Utah, United States
Status: Recruiting
Contact: R. J. Lee - 801-507-3950
Dixie Medical Center Regional Cancer Center
Saint George, Utah, United States
Status: Recruiting
Contact: R. J. Lee - 801-507-3950
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States
Status: Recruiting
Contact: Matthew M. Poppe - 801-581-4477 - clinical.trials@hci.utah.edu
LDS Hospital
Salt Lake City, Utah, United States
Status: Recruiting
Contact: R. J. Lee - 801-507-3950
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, United States
Status: Recruiting
Contact: R. J. Lee - 801-507-3950
University of Virginia Cancer Center
Charlottesville, Virginia, United States
Status: Recruiting
Contact: Susan C. Modesitt - 434-243-6143
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, United States
Status: Recruiting
Contact: Weldon E. Chafe - 804-628-1939
Carilion Clinic Gynecological Oncology
Roanoke, Virginia, United States
Status: Recruiting
Contact: Janet L. Osborne - 540-985-8510
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States
Status: Recruiting
Contact: Ali Mahdavi - 414-649-5717
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States
Status: Recruiting
Contact: Kristin A. Bradley - 877-405-6866
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, United States
Status: Recruiting
Contact: Ali Mahdavi - 414-649-5717
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Status: Recruiting
Contact: William H. Bradley - 414-805-4380
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States
Status: Recruiting
Contact: Ali Mahdavi - 414-649-5717
Aurora West Allis Medical Center
West Allis, Wisconsin, United States
Status: Active, not recruiting
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming, United States
Status: Recruiting
Contact: Keren Sturtz - 888-785-6789
Welch Cancer Center
Sheridan, Wyoming, United States
Status: Recruiting
Contact: Benjamin T. Marchello - 800-648-6274
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada
Status: Active, not recruiting
London Regional Cancer Program
London, Ontario, Canada
Status: Active, not recruiting
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
Status: Recruiting
Contact: Anthony W. Fyles - 416-946-4501 - clinical.trials@uhn.on.ca
CHUM - Hopital Notre-Dame
Montreal, Quebec, Canada
Status: Recruiting
Contact: Maroie Barkati - 514-890-8000 - sylvie.beaudoin.chum@ssss.gouv.qc.ca
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
Status: Recruiting
Contact: Evgeny Sadikov - 306-766-2213
King Faisal Specialist Hospital and Research Centre
Riyadh, Saudi Arabia
Status: Recruiting
Contact: Hamed H. Al-Husaini - 011-966-1-464-7272
National University Hospital Singapore
Singapore, Singapore
Status: Active, not recruiting
Start Date
January 2012
Sponsors
Gynecologic Oncology Group
Source
Gynecologic Oncology Group
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page