Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer
Conditions
Colorectal Neoplasms
Conditions: official terms
Colorectal Neoplasms
Conditions: Keywords
colonoscopy, colorectal neoplasms, screening, family history
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls.

Design: Single-center prospective study
Detailed Description
Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 49 Years
Minimum Age: 30 Years
Gender: Both
Criteria: Inclusion Criteria:

- 30- to 49-year-old asymptomatic subjects

- First relative history of colorectal cancer

Exclusion Criteria:

- previous colonoscopy for any reason

- personal history of colorectal adenomas or CRC

- history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease

- documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or

- iron deficiency anemia

- unexplained weight loss of >10% of the body weight in the 6 months before colonoscopy

- incomplete examination of entire colon
Location
Asan Medical Center
Seoul, Korea, Republic of
Status: Recruiting
Contact: Kyung-Jo Kim, M.D - 82230103196 - capsulendos@gmail.com
Start Date
September 2011
Completion Date
September 2014
Sponsors
Asan Medical Center
Source
Asan Medical Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page