3D Breast Ultrasound Elastography in Patients Under Neoadjuvant Chemotherapy
Malignant Breast Tumours
Conditions: official terms
Breast Neoplasms
Study Type
Study Phase
Study Design
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Name: 3D Ultrasound elastography by means of shear wave propagation into breast tissue
Type: Device
Overall Status
Breast Ultrasound Elastography is a complementary technique permitting a better characterization of breast lesions. 3D breast ultrasound elastography is a novel technique permitting a volumetric calculation of lesion stiffness. This could be particularly useful in patients with large breast tumors under pre-operative chemotherapy
Detailed Description
3D breast ultrasound elastography provides volumetric lesion stiffness details in real time. 3D acquisition is compared to breast MRI in order to evaluate volume measurements calculated in ultrasound. Lesion elasticity is calculated in 3 planes with immediate reconstruction. The purpose of this prospective study is to evaluate the feasibility of this technique and compare the results to those of Breast MRI. For women receiving preoperative chemotherapy, this technique will be evaluated with regard to tumour shrinkage and lesion elasticity modifications under treatment.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 75 Years
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- Patients having already undergone a breast MRI

- Patients presenting with breast lesions measuring between20-50mm in ultrasound

Exclusion Criteria:

- Multifocal lesions

- History of breast cancer

- Breast implants

- Inflammatory breast disease

- Pregnancy
Curie Cancer Institute
Paris, France
Status: Recruiting
Contact: Alexandra Athanasiou, MD - +33156245823 - alexandra.athanasiou@curie.net
Start Date
December 2010
Completion Date
September 2013
Institut National de la Santé Et de la Recherche Médicale, France
Institut National de la Santé Et de la Recherche Médicale, France
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page