Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer
Conditions
Lung Neoplasms
Conditions: official terms
Lung Neoplasms
Conditions: Keywords
Oncogenes, Lung and Other Thoracic Cancers
Study Type
Observational
Study Phase
N/A
Study Design
Time Perspective: Prospective
Overall Status
Recruiting
Summary
The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.
Detailed Description
To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 85 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

1. Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies

2. Aged 18 years or older

3. Either be:a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, CT or US-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.

4. Patients must have the ability to understand and willingness to sign an informed consent document.

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Exclusion Criteria:

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Location
University of Colorado Cancer Center
Aurora, Colorado, United States
Status: Recruiting
Contact: Mary K. Jackson - 303-724-1650 - mary.k.jackson@ucdenver.edu
Start Date
December 2011
Completion Date
May 2016
Sponsors
University of Colorado, Denver
Source
University of Colorado, Denver
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page