Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer
Conditions
Small Cell Carcinoma of Lung
Conditions: official terms
Carcinoma, Small Cell - Lung Neoplasms - Small Cell Lung Carcinoma
Conditions: Keywords
Irinotecan, UGT1A1 Gene Polymorphisms, Small Cell Carcinoma of Lung
Study Type
Interventional
Study Phase
Phase 2
Study Design
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Irinotecan
Type: Drug
Overall Status
Recruiting
Summary
The purpose of this study is to find out the correlation between uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer.
Detailed Description
In multiple studies of metastatic colorectal cancer,uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and its correlation with irinotecan-associated side effects have been confirmed.Data from several studies indicated an improved clinical outcome of patients who had received an irinotecan-based regimen.In order to find out the correlation between UGT1A1 gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer,we designed this study.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 75 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Clinical diagnosis of refractory or relapsed small cell lung cancer

- Physical examination and routine laboratory tests show no contraindications to chemotherapy

Exclusion Criteria:

- Pregnant and nursing women

- Brain metastasis with symptoms
Location
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Status: Recruiting
Contact: Fan Yun - 0086-571-88122192 - fanyun@csco.org.cn
Start Date
June 2012
Completion Date
June 2014
Sponsors
Zhejiang Cancer Hospital
Source
Zhejiang Cancer Hospital
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page