Study of a Predictor for Cervix Cancer
Conditions
Cervix Cancer - Radiochemotherapy
Conditions: official terms
Uterine Cervical Neoplasms
Study Type
Interventional
Study Phase
Phase 2
Study Design
Intervention Model: Single Group Assignment, Masking: Open Label
Intervention
Name: local control at 19.8Gy
Type: Procedure
Overall Status
Recruiting
Summary
Non operated cervix cancer (diameter > 4 cm) and stade Ib2-IIb are usually treated by radio-chemotherapy.

Non control local rate is inexplicably close to 30%. However, important volume of those tumors and their hypoxia degree induce phenomenon of pathologic angiogenesis, explaining these therapeutic failures.

Persistence of tumor hypoxia could be a predictive factor of local control
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 65 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- cervix epidermoid cancer or adenocarcinoma(IB2, IIA, and IIB)

- treatment by radiochemotherapy

- tumor diameter at least 4 cm

- patient accepting not to smoke from 3 days prior to first cervix biopsies until end of treatment

- ECOG ≤ 1

- social and psychological compliance for standard treatment of radiochemotherapy for cervix carcinoma

- patient affiliated to health insurance system

- signed informed consent
Location
Oscar Lambret Center
Lille, France
Status: Recruiting
Contact: Philippe NICKERS, MD PhD - +33 (0)3.20.29.59.11 - p-nickers@o-lambret.fr
Start Date
January 2012
Completion Date
May 2016
Sponsors
Centre Oscar Lambret
Source
Centre Oscar Lambret
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page