Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging
Lung Cancer With Mediastinal Lymph Node Involvement
Conditions: official terms
Lung Neoplasms
Conditions: Keywords
Lung cancer, EBUS-TBNA, Epigenetics, shox2 protein, human
Study Type
Study Phase
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Name: No intervention
Type: Other
Overall Status
A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 90 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- clinical diagnosis of lung cancer

- enlarged mediastinal or hilar lymph nodes (>10 mm)

Exclusion Criteria:

- clinical condition which excludes general anesthesia
Ruhrlandklinik - Universitätsklinikum Essen
Essen, Germany
Status: Recruiting
Contact: Kaid Darwiche, MD - +49201433 -
Start Date
February 2012
University Hospital, Essen
University Hospital, Essen
Record processing date processed this data on July 28, 2015 page