Effects of Chemotherapy on Muscle Mass and Exercise Performance in Patients With Oesophageal Cancer.
Conditions
Oesophageal Adenocarcinoma
Conditions: official terms
Adenocarcinoma - Esophageal Neoplasms
Conditions: Keywords
neoadjuvant chemotherapy, oesophageal cancer, cardiorespiratory performance
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Intervention
Name: DEXA scan Type: Radiation
Name: Muscle biopsy Type: Procedure
Name: cardio-pulmonary exercise testing (CPEX) Type: Other
Overall Status
Recruiting
Summary
Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.
Detailed Description
We aim to review the effects of chemotherapy on skeletal muscle mass and cardio-respiratory performance in patients with oesophageal adenocarcinoma. All patients will be assessed by a Consultant Anaesthetist and a medical member of the Research team before commencing chemotherapy and after finishing their course. These assessments include a nutritional assessment, performance status assessments, blood assays, dual energy X-ray absorptiometry (DEXA) scans, cardio-pulmonary exercise (CPEX) testing and a muscle biopsy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- oesophageal cancer

- Multidisciplinary team decision to offer neoadjuvant chemotherapy prior to surgery

Exclusion Criteria:

- Metastatic disease
Location
Graduate Entry Medical School, University of Nottingham
Derby, Derbyshire, United Kingdom
Status: Recruiting
Start Date
October 2011
Completion Date
November 2013
Sponsors
University of Nottingham
Source
University of Nottingham
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page