A Study of Pancreatic Cancer in Xenografts From Liver Metastases
Conditions
Pancreatic Cancer - Liver Metastases - Tumor Tissue Biopsy - Blood Samples
Conditions: official terms
Liver Neoplasms - Neoplasm Metastasis - Pancreatic Neoplasms
Conditions: Keywords
Pancreatic cancer, Liver metastases, Tumor tissue biopsy, Blood samples, Xenografts, Murine, Genomic profiling, Circulating biomarkers
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
This is a feasibility study to perform image-guided liver biopsies in 25 patients who have pancreatic cancer with liver metastasis (cancer in the pancreas that has spread to the liver). This will contribute with samples for the bio-bank (bank of tumors) and develop xenografts (human tumors growing in mice) for further analysis of genes.
Detailed Description
This study might bring a better understanding of the metastatic pancreatic cancer and evaluate the differences between the metastatic and the primary pancreatic cancer (the type that does not have metastasis).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Minimum age of 18 years old

- Pancreatic cancer with liver metastasis

- No contraindication to image-guided biopsy of liver metastasis, including uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine etc) and no significant hepatic dysfunction.

- Provide written informed consent

- ECOG 0,1 or 2

Exclusion Criteria:

- Inability to lie supine for more than 30 minutes

- ECOG 3 or more

- Serious medical risk factors involving any of the major organ systems or including uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine etc) and no significant hepatic dysfunction.
Location
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Status: Recruiting
Start Date
January 2013
Completion Date
June 2015
Sponsors
University Health Network, Toronto
Source
University Health Network, Toronto
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page