Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
Brain Neoplasms
Conditions: official terms
Brain Neoplasms
Conditions: Keywords
Magnetic Resonance Imaging
Study Type
Observational [Patient Registry]
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Patient 18 years and older

- Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery

- Patient able of accepting protocol information

- Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion Criteria:

- Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI

- Claustrophobic patient

- Patients who cannot cooperate for the fMRI

- Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
Rennes University Hospital
Rennes, France
Status: Recruiting
Start Date
September 2013
Completion Date
July 2016
Rennes University Hospital
Rennes University Hospital
Record processing date processed this data on July 28, 2015 page