A Feasibility Study of Chemo-radiotherapy to Treat Operable Oesophageal Cancer
Conditions
Oesophageal Cancer
Conditions: official terms
Esophageal Neoplasms
Conditions: Keywords
Oesophageal cancer
Study Type
Interventional
Study Phase
Phase 2
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Oxaliplatin Type: Drug
Name: Capecitabine Type: Drug
Name: Carboplatin Type: Drug
Name: Paclitaxel Type: Drug
Name: Radiotherapy Type: Radiation
Name: Surgery Type: Procedure
Overall Status
Recruiting
Summary
About 7500 patients are diagnosed with oesophageal cancer each year in the UK of which less than a quarter have resectable disease at diagnosis. There is a general lack of consistency in the standard of care for patients across UK hospitals. Patients are either treated with a) chemotherapy followed by surgical removal of the tumour, or b) chemoradiotherapy followed by removal of the tumour by surgery, as part of their standard of care. Recent research supports the latter treatment, as chemoradiotherapy maybe more effective at shrinking the tumour and preventing the disease from spreading than taking chemotherapy alone. However, there is no definitive way of identifying which treatment is best without a clinical trial.

Evidence suggests that the effect of the chemoradiotherapy currently used as standard practice may be improved and the side effects reduced by using a different chemoradiotherapy combination. In this trial, eligible patients will receive 2 cycles of the same chemotherapy before being randomised to receive two different chemoradiotherapy regimens (carboplatin and paclitaxel verses oxaliplatin and capecitabine) both of which have shown promising results in previous studies. Patients will then have their tumour removed. The best chemoradiotherapy regimen will then be taken forward to a Phase III trial in which chemoradiotherapy will be compared with chemotherapy alone.

The efficacy of the regimens will be measured by counting the number of patients who i) remain free from cancer, ii)have local or distant spread of their cancer, iii) are successfully recruited and iv) experience toxicities. A specific set of toxicity criteria will be used to monitor any treatment induced side-effects and provide justification for any necessary dose modifications or withdrawal of treatment.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically confirmed operable oesophageal cancer (adenocarcinoma)

- Tumour must be staged as a T3, 4 or N1 (using TNM6 staging) or T3, T4a or N13 using TNM7 staging)

- Maximum disease (Tumour plus nodes) length 8 cm staged with EUS and CT/PET

- WHO performance status 01

- Adequate haematological, renal, respiratory, cardiac and hepatic function

- The patient has provided written informed consent.

Exclusion Criteria:

- Histologically confirmed operable oesophageal cancer (squamous cell carcinoma)

- Uncontrolled angina pectoris, myocardial infarction within 6 months, heart failure, clinically significant uncontrolled cardiac arrhythmias, or any patient with a clinically significant abnormal ECG.

- Patients with any previous treatment for oesophageal carcinoma.

- Siewert type 3 oesophagogastric tumours.

- T4 tumours invading contiguous structures other than diaphragm, crura or mediastinal pleura.

- Patients with disease in any of the following areas on the CT scan, EUS or other staging investigation:

1. Evidence of metastases in liver, lung, bone or other distant metastases.

2. Abdominal para aortic lymphadenopathy >1cm diameter on CT or >6mm diameter on EUS.

3. Invasion of tracheo-bronchial tree, aorta, pericardium or lung.

- Lymphadenopathy encasing the coeliac axis (as described above, patients with single nodes lying anterior to the origin of the splenic artery and anterior to the origin of the coeliac axis are not excluded).

- Any patient with a single significant medical condition which is thought likely to compromise his or her ability to tolerate any of the above therapies.

- Specific contraindications to surgery, chemotherapeutic agents (including known allergies to chemotherapy) or radiotherapy.

- Pregnant or lactating women and fertile women who will not be using adequate contraception during the trial.
Locations
Bristol Oncology and Haematology Centre
Bristol, United Kingdom
Status: Recruiting
Valindre NHS
Cardiff, United Kingdom
Status: Recruiting
University Hospitals Coventry and Warwickshire
Coventry, United Kingdom
Status: Recruiting
Royal Derby Hospital
Derby, United Kingdom
Status: Not yet recruiting
St James's Hospital
Leeds, United Kingdom
Status: Recruiting
Leicester Royal Infirmary
Leicester, United Kingdom
Status: Recruiting
St Mary's Hopsital
London, United Kingdom
Status: Recruiting
The Christie
Manchester, United Kingdom
Status: Recruiting
Churchill Hospital
Oxford, United Kingdom
Status: Recruiting
Weston Park Hospital
Sheffield, United Kingdom
Status: Recruiting
Southampton General Hospital
Southampton, United Kingdom
Status: Recruiting
The Great Western Hospital
Swindon, United Kingdom
Status: Recruiting
Start Date
October 2013
Completion Date
May 2016
Sponsors
Lisette Nixon
Source
Velindre NHS Trust
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page