Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer
Conditions
Thyroid Cancer
Conditions: official terms
Thyroid Diseases - Thyroid Neoplasms
Conditions: Keywords
non-anaplastic, non-medullary, radiation, IMRT, Doxorubicin, 13-070
Study Type
Interventional
Study Phase
Phase 2
Study Design
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: IMRT Type: Radiation
Name: DWI MRI Type: Device
Name: Doxorubicin Type: Drug
Name: Modified Barium Swallow Impairment Profile (MBSImP) Type: Other
Overall Status
Recruiting
Summary
The purpose of this Phase 2 study is to find out what effect, good and/or bad, external beam radiation therapy, has on the patient and their thyroid cancer where surgery is not an option or where despite surgery, the disease is still present.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Pathologically confirmed diagnosis of non-anaplastic non-medullary thyroid cancer that is either grossly recurrent after surgery or unresectable with or without metastatic disease.

- Age ≥18 years

- Karnofsky performance status ≥70%

- Men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months after treatment.

- Patients must have ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

- Women who are pregnant or lactating

- Inability to comply with study and/or follow-up procedures
Locations
Memorial Sloan Kettering Cancer Center at Basking Ridge
Basking Ridge, New Jersey, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Memorial Sloan Kettering Cancer Center at Commack
Commack, New York, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Memorial Sloan Kettering Cancer Center at Mercy Medical Center
Rockville Centre, New York, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center
Sleepy Hollow, New York, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Memorial Sloan Kettering West Harrison
West Harrison, New York, United States
Status: Recruiting
Contact: Nancy Lee, MD - 212-639-3341
Start Date
June 2013
Completion Date
June 2016
Sponsors
Memorial Sloan Kettering Cancer Center
Source
Memorial Sloan Kettering Cancer Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page