Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer
Conditions
Non-Small-cell Lung Cancer
Conditions: official terms
Carcinoma, Non-Small-Cell Lung - Lung Neoplasms
Conditions: Keywords
Biopsy, Maximal incremental cardiopulmonary test, Muscle strength test, magnetic stimulation
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown.

Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis.

Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days.

During the evaluation the following tests will be done:

- Anthropometric measures

- Level of daily physical activity

- Pulmonary function test

- Maximal incremental cardiopulmonary exercise test on ergocycle

- Endurance test on ergocycle

- Muscle function tests

- Magnetic stimulation

- Quadriceps biopsy
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: 80 Years
Minimum Age: 40 Years
Gender: Both
Criteria: Inclusion Criteria:

- Men and women with a primary lung cancer diagnosis

Exclusion Criteria:

- Already have undertaken surgery, chemotherapy or radiotherapy treatment

- Having an other cancer in the last five years

- Taking anticoagulation therapy
Location
Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, Canada
Status: Recruiting
Contact: Didier Saey, PhD - 418-656-8711 - didier.saey@criucpq.ulaval.ca
Start Date
February 2013
Completion Date
May 2015
Sponsors
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Source
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page