Radiotherapy Alternates Human Epidermal Growth Factor 2 (Her2) Expression in Human Breast Cancer
Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Conditions: official terms
Breast Neoplasms
Conditions: Keywords
Breast, Cancer, Human Epidermal Growth Factor 2 (Her2), irradiation
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Prospective
Overall Status
Based on fundamental study (in Vitro and in Vivo, Pro. Jianjian Li), Her2 expression would be changed from negative to positive by cancer irradiation with liner-accelerator at dose 6GY or up. The propose of this study is to reveal the irradiation result on Her2 expression in human breast cancer.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 80 Years
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- histological confirmed advanced breast cancer

- cancer sample can be obtained by fine needle biopsy

- IHC and FISH confirmed Her2 negative

- radiotherapy indication for local residual cancer

Exclusion Criteria:

- no radiotherapy indication

- patient refuse
Qingdao Central Hospital, Qingdao Cancer Hospital
Qingdao, Shandong, China
Status: Recruiting
Contact: youxin ji, M.D. - 8653268665078 -
Start Date
August 2013
Completion Date
December 2015
Qingdao Central Hospital
Qingdao Central Hospital
Record processing date processed this data on July 28, 2015 page