Pharmacokinetics and Pharmacodynamics of BI 695500 vs. Rituximab as First Line-treatment in Patients With Low Tumor Burden Lymphoma
Conditions
Lymphoma, Follicular
Conditions: official terms
Lymphoma - Lymphoma, Follicular
Study Type
Interventional
Study Phase
Phase 1
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Intervention
Name: BI 695500 Type: Drug
Name: MabThera Type: Drug
Overall Status
Recruiting
Summary
The primary objective of the study is to assess the pharmacokinetic (PK) similarity of Boehringer Ingelheim (BI) 695500 vs. rituximab (MabThera®) in previously untreated patients with low tumor burden follicular lymphoma (LTBFL).

The secondary objective of the study is to evaluate the pharmacodynamics (PD), safety, and anti-tumor activity of BI 695500 vs. rituximab (MabThera®), as well as the presence of anti-drug antibodies (ADAs).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion criteria:

- Must give written informed consent and be willing to follow this CTP.

- Male or female patients, at least 18 years of age at Screening.

- Histologically-confirmed, stage II - IV NHL (CD20+ FL of Grades 1, 2, or 3a).

- Low tumor burden according to the GELF criteria - no nodal or extranodal involvement of more than 7 cm, no more than 3 nodal sites with a diameter >3 cm, no B symptoms (i.e., fever >38°C, weight loss - unexplained loss of >10 % body weight over the past 6 months, and sweats - the presence of drenching night sweats), no significant splenomegaly, no significant serious effusion, no complications such as organ compression, and less than 5x10^9/L circulating tumor cells.

- Availability of archived tumor sample prior to screening.

- Patients not previously treated for their FL.

- ECOG performance status of 0 to 1.

- Have at least 1 measurable lesion as per the International Working Group (IWG) criteria 2007 at Screening (lesion clearly measurable in at least 2 perpendicular dimensions; see Appendix 10.1 for further details).

- Adequate hematological function (unless abnormalities are related to lymphoma infiltration of the bone marrow) within 28 days prior to randomization, including:

- - hemoglobin =9.0 g/dL (=5.6 mmol/L).

- - absolute neutrophil count =1.5 × 10^9/L.

- - platelet count =100 × 10^9/L.

- Adequate renal and liver function:

- - serum creatinine <2.0 mg/dL (<176.8 mcmol/L).

- - total bilirubin <2.0 mg/dL (<34 mcmol/L) except for patient with Gilbert's Syndrome or Hemolysis. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <3 x upper limit of normal (ULN) (<5 x ULN is acceptable if abnormalities are thought to be related to hepatic infiltration by FL).

- For participants of reproductive potential (males and females), use of a medically acceptable method of contraception during the trial, i.e., a combination of 2 forms of effective contraception (defined as hormonal contraception, intrauterine device, condom with spermicide, etc.). Females of childbearing potential (includes tubal ligation) and males with female partners of childbearing potential must also agree to use an acceptable method of contraception (see above) for 12 months following completion or discontinuation from the trial medication.

Exclusion criteria:

- Transformation to high-grade lymphoma (secondary to low-grade lymphoma).

- Presence or history of central nervous system lymphoma.

- Patients receiving current treatment with corticosteroids must not be receiving a dose exceeding 20 mg/day prednisone or equivalent.

- Patients with prior or concomitant malignancies within 5 years prior to screening except non-melanoma skin cancer, adequately treated carcinoma in situ of the cervix, adequately treated breast cancer in situ, localized prostate cancer stage T1c - provided that the patient underwent curative treatment, and remains relapse free.

- Major surgery (excluding lymph node biopsy) within 28 days prior to randomization.

- Active, chronic or persistent infection that might worsen with immunosuppressive treatment (e.g., Human Immunodeficiency Virus [HIV], Hepatitis C Virus [HCV], Herpes Zoster); positive for HIV or tuberculosis at Screening.

- Patients with serological evidence of HBV infection. Patients seropositive because of HBV vaccine are eligible. HBV positive patients may participate following consultation with a hepatitis expert regarding monitoring and use of HBV antiviral therapy, and provided they agree to receive treatment as indicated.

- Serious underlying medical conditions, which, per the investigator's discretion, could impair the ability of the patient to participate in the trial (including but not limited to ongoing active infection, severe immunosuppression, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease); patients who have significant cardiac disease, including but not limited to congestive heart failure of Class III or IV of the NYHA classification; uncontrolled angina or arrhythmia; any uncontrolled or severe cardiovascular or cerebrovascular disease.

- Known hypersensitivity or allergy to murine products.

- History of a severe allergic reaction or anaphylactic reaction to a biological agent or history of hypersensitivity to any component of the trial drug.

- Receipt of a live/attenuated vaccine within 12 weeks prior to the Screening Visit.

- Prior treatment with BI 695500 and/or rituximab.

- Patients who received any prior therapy using monoclonal antibodies will be excluded; this does not apply to other biological drugs such as growth factors or anticoagulants.

- Treatment within a clinical trial within 4 weeks prior to initiation of trial treatment. Patients who have received treatment with a drug that has not received regulatory approval for any indication within 4 weeks or a minimum of 5 half-lives, whichever is longer, of the initial dose of trial medication.

- Any other co-existing medical or psychological condition(s) that will preclude participation in the trial or compromise ability to give informed consent and/or comply with study procedures.

- Pregnancy or breast feeding. For women of childbearing potential, a positive serum pregnancy test at the Screening Visit.

- Patients who have significant cardiac disease, including but not limited to congestive heart failure of Class III or IV of the New York Heart Association (NYHA) classification; uncontrolled angina or arrhythmia; any uncontrolled or severe cardiovascular or cerebrovascular disease; or uncontrolled hypertension.
Locations
1301.5.0218 Boehringer Ingelheim Investigational Site
Canberra, Australia
Status: Recruiting
1301.5.6606 Boehringer Ingelheim Investigational Site
Innsbruck, Austria
Status: Recruiting
1301.5.6602 Boehringer Ingelheim Investigational Site
Wien, Austria
Status: Recruiting
1301.5.0306 Boehringer Ingelheim Investigational Site
Bruxelles, Belgium
Status: Recruiting
1301.5.0304 Boehringer Ingelheim Investigational Site
Edegem, Belgium
Status: Recruiting
1301.5.0308 Boehringer Ingelheim Investigational Site
Leuven, Belgium
Status: Recruiting
1301.5.0302 Boehringer Ingelheim Investigational Site
Namur, Belgium
Status: Recruiting
1301.5.1004 Boehringer Ingelheim Investigational Site
Rijeka, Croatia
Status: Recruiting
1301.5.1002 Boehringer Ingelheim Investigational Site
Zagreb, Croatia
Status: Recruiting
1301.5.1104 Boehringer Ingelheim Investigational Site
Brno, Czech Republic
Status: Recruiting
1301.5.1102 Boehringer Ingelheim Investigational Site
Ostrava-Poruba, Czech Republic
Status: Recruiting
1301.5.1108 Boehringer Ingelheim Investigational Site
Praha 2, Czech Republic
Status: Recruiting
1301.5.1514 Boehringer Ingelheim Investigational Site
Angers, France
Status: Recruiting
1301.5.1508 Boehringer Ingelheim Investigational Site
Bordeaux cedex, France
Status: Recruiting
1301.5.1510 Boehringer Ingelheim Investigational Site
Brest, France
Status: Recruiting
1301.5.1506 Boehringer Ingelheim Investigational Site
La Roche sur Yon, France
Status: Recruiting
1301.5.1504 Boehringer Ingelheim Investigational Site
Pessac, France
Status: Recruiting
1301.5.1502 Boehringer Ingelheim Investigational Site
Poitiers, France
Status: Recruiting
1301.5.1704 Boehringer Ingelheim Investigational Site
Bad Nauheim, Germany
Status: Recruiting
1301.5.1734 Boehringer Ingelheim Investigational Site
Dresden, Germany
Status: Recruiting
1301.5.1706 Boehringer Ingelheim Investigational Site
Frankfurt, Germany
Status: Recruiting
1301.5.1702 Boehringer Ingelheim Investigational Site
Freiburg, Germany
Status: Recruiting
1301.5.1712 Boehringer Ingelheim Investigational Site
Goslar, Germany
Status: Recruiting
1301.5.1722 Boehringer Ingelheim Investigational Site
Hamburg, Germany
Status: Recruiting
1301.5.1710 Boehringer Ingelheim Investigational Site
Heidelberg, Germany
Status: Recruiting
1301.5.1716 Boehringer Ingelheim Investigational Site
Kassel, Germany
Status: Recruiting
1301.5.1804 Boehringer Ingelheim Investigational Site
Athens, Greece
Status: Recruiting
1301.5.1802 Boehringer Ingelheim Investigational Site
Patra, Greece
Status: Not yet recruiting
1301.5.2102 Boehringer Ingelheim Investigational Site
Budapest, Hungary
Status: Recruiting
1301.5.3402 Boehringer Ingelheim Investigational Site
Auckland, New Zealand
Status: Recruiting
1301.5.3904 Boehringer Ingelheim Investigational Site
Warszawa, Poland
Status: Recruiting
1301.5.4302 Boehringer Ingelheim Investigational Site
Omsk, Russian Federation
Status: Recruiting
1301.5.4304 Boehringer Ingelheim Investigational Site
St. Petersburg, Russian Federation
Status: Recruiting
1301.5.4306 Boehringer Ingelheim Investigational Site
St. Petersburg, Russian Federation
Status: Recruiting
1301.5.4602 Boehringer Ingelheim Investigational Site
Bratislava, Slovakia
Status: Recruiting
1301.5.4814 Boehringer Ingelheim Investigational Site
Badalona, Spain
Status: Recruiting
1301.5.4808 Boehringer Ingelheim Investigational Site
Cádiz, Spain
Status: Recruiting
1301.5.4818 Boehringer Ingelheim Investigational Site
Madrid, Spain
Status: Recruiting
1301.5.4810 Boehringer Ingelheim Investigational Site
Sevilla, Spain
Status: Recruiting
1301.5.4816 Boehringer Ingelheim Investigational Site
Vitoria, Spain
Status: Recruiting
Start Date
September 2013
Completion Date
January 2016
Sponsors
Boehringer Ingelheim
Source
Boehringer Ingelheim
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page