ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Low-dose Dex in Relapsed-and-Refractory Multiple Myeloma
Conditions
Multiple Myeloma
Conditions: official terms
Multiple Myeloma - Neoplasms, Plasma Cell
Conditions: Keywords
Multiple Myeloma, Neoplasms, Plasma Cell, Neoplasms by Histologic Type, Neoplasms, Blood Protein Disorders, Hematologic Diseases, Dexamethasone, Dexamethasone acetate, Pomalidomide
Study Type
Interventional
Study Phase
Phase 1/Phase 2
Study Design
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: ACY-1215 (Ricolinostat) in combination with pomalidomide and dexamethasone
Type: Drug
Overall Status
Recruiting
Summary
Phase 1b: To evaluate the side effects and determine the best dose of ACY-1215 in combination with Pomalidomide and low-dose dexamethasone in patients with relapsed-and-refractory multiple myeloma.

Phase 2: To determine the overall response rate of ACY-1215 in combination with Pomolidomide and low-dose dexamethasone in patients with relapsed-and-refractory multiple myeloma
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Must have a documented diagnosis of multiple myeloma and have relapsed-and-refractory disease. Patients must have received at least 2 lines of prior therapies. Patients must have relapsed after having achieved at least stable disease (SD) for at least one cycle of treatment to at least one prior regimen and then developed progressive disease (PD). Patients must also have documented evidence of PD during or within 60 days (measured from the end of the last cycle) of completing treatment with the last anti-myeloma drug regimen used just prior to study entry (refractory disease)

- Must have undergone prior treatment with at least 2 cycles of lenalidomide and at least 2 cycles of a proteasome inhibitor (either in separate regimens or within the same regimen)

- Must not be a candidate for autologous stem cell transplant (ASCT), has declined the option of ASCT, or has relapsed after prior ASCT

- Must have measurable levels of myeloma paraprotein in serum (≥ 0.5 g/dL) or urine (≥ 0.2 g/24 hours)

- Must have Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2

- Females of child bearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days prior to, and again within 24 hours of starting pomalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking pomalidomide. FCBP must also agree to ongoing pregnancy testing. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a vasectomy. All patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure. Risks of Fetal Exposure, Pregnancy Testing Guidelines and Acceptable Birth Control Methods,and Education and Counseling Guidance must be followed per protocol

- Must be able to take acetylsalicylic acid (ASA) (81 or 325 mg) daily as prophylactic anticoagulation. Patients intolerant to ASA may use low molecular weight heparin. Lovenox is recommended. Coumadin will be allowed provided the patient is fully anticoagulated, with an international normalized ratio (INR) of 2 to 3

Exclusion Criteria:

- Pregnant or lactating females

- Prior therapy with HDAC inhibitor

- Any of the following laboratory abnormalities:

- ANC < 1,000/µL

- Platelet count < 75,000/ µL for patients in whom < 50% of bone marrow nucleated cells are plasma cells; and < 50,000/ µL for patients in whom ≥ 50% of bone marrow nucleated cells are plasma cells

- Hemoglobin < 8g/dL (<4.9 mmol/L; prior red blood cell [RBC] transfusion is permitted)

- Creatine clearance < 45mL/min according to Cockcroft-Gault formula. If creatine clearance calculated from the 24-hour urine sample is ≥ 45 mL/min, patient will qualify for the study

- Serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST), or serum glutamic pyruvic transaminase (SGPT)/ alanine aminotransferase (ALT) > 3.0 × ULN

- Serum total bilirubin > 2.0 mg/dL

- Prior history of malignancies, other than MM, unless the patient has been free of the disease for ≥ 3 years. Exceptions include the following:

- Basal or squamous cell carcinoma of the skin

- Carcinoma in situ of the cervix or breast

- Incidental histologic finding of prostate cancer (TNM stage of T1a or T1b)

- Corrected QT interval using Fridericia's formula (QTcF) value > 480 msec at screening; family or personal history of long QTc syndrome or ventricular arrhythmias including ventricular bigeminy; previous history of drug-induced QTc prolongation or the need for treatment with medications known or suspected of producing prolonged QTc intervals on electrocardiogram (ECG)

- Positive human immunodeficiency virus (HIV), hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection

- Hypersensitivity to thalidomide, lenalidomide, or dexamethasone (such as Steven Johnson Syndrome). Hypersensitivity, such as rash, that can be medically managed is allowable

- Peripheral neuropathy ≥ Grade 2 desipite supportive therapy

- Radiotherapy or systemic therapy (standard or an investigational or biologic anticancer agent) within 14 days of initiation of study drug treatment

- Current enrollment in another clinical trial involving treatment and/or is receiving an investigational agent for any reason

- Inability or unwillingness to comply with birth control requirements or regional REMS/RevAid programs
Locations
Winship Cancer Institute
Atlanta, Georgia, United States
Status: Recruiting
Contact: Chika Obidike - 404-778-5920 - c.o.obidike@emory.edu
Horizon Oncology Research Inc
Lafayette, Indiana, United States
Status: Recruiting
Contact: Kristen McKinley, RN - 765-446-5111 - kmckinley@horizonbioadvance.com
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Status: Recruiting
Contact: Catherine Flynn - 617-632-3788 - catherine_flynn@dfci.harvard.edu
Massachusetts General Hospital
Boston, Massachusetts, United States
Status: Recruiting
Contact: Ellen Wallace - 617-643-3959 - ewallace3@mgh.harvard.edu
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Status: Recruiting
Contact: Erica Chapman - 734-232-0716 - echapman@med.umich.edu
Washington University School of Medicine at St. Louis
St. Louis, Missouri, United States
Status: Recruiting
Contact: Brett Ramsey - 314-747-2844 - bramsey@wusm.wustl.edu
New York Medical College
Hawthorne, New York, United States
Status: Recruiting
Contact: Karen Seiter - 914-493-8375
New York Medical College
Hawthorne, New York, United States
Status: Not yet recruiting
Contact: Paul Baskind - 914-493-8375 - paul_baskind@nymc.edu
Mt. Sinai Medical Center
New York, New York, United States
Status: Recruiting
Contact: Christine Pun - 212-241-5134 - christine.pun@mssm.edu
Mt. Sinai Medical Center
New York, New York, United States
Status: Recruiting
Contact: Kenneth Lau - 212-241-7846 - kenneth.lau@mssm.edu
Cleveland Clinic
Cleveland, Ohio, United States
Status: Recruiting
Contact: Sherry Fada - 216-445-6235 - fadas@ccf.org
Ohio State University, James Cancer Hospital
Columbus, Ohio, United States
Status: Recruiting
Contact: Katie Stamper - 614-366-6386 - kathleen.stamper@osumc.edu
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, United States
Status: Recruiting
Contact: Justin Mazur - 412-647-0864 - mazurjr@upmc.edu
Univ of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Status: Recruiting
Contact: Kathleen Cobb, RN - 210-450-5893 - cobb@uthscsa.edu
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Status: Recruiting
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
Status: Recruiting
Contact: Cari Morin - 206-667-6238 - cmorin@fhcrc.org
Fred Hutchinson Cancer Research Institute
Seattle, Washington, United States
Status: Recruiting
Contact: Cari Morin - 206-667-6238 - cmorin@fhcrc.org
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Status: Recruiting
Contact: Marilyn Linde - 414-805-4196 - mlinde@mcw.edu
Medical College of Wisconsin - Clinical Cancer Center
Milwaukee, Wisconsin, United States
Status: Recruiting
Contact: Paulette Jacobs - 414-805-4594 - pjacobs@mcw.edu
Tom Baker Cancer Center
Calgary, Alberta, Canada
Status: Recruiting
Contact: Danish Bhuiya - (403) 521-3452 - danish.bhuiya@albertahealthservices.ca
Cross Cancer Institute
Edmonton, Alberta, Canada
Status: Recruiting
Contact: Jenna Gursky, RN - (780) 989-5970 - jennifer.gursky@albertahealthservices.ca
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Status: Not yet recruiting
Contact: Diana Arones - (416) 946-2824 - diana.arones@uhn.ca
A.O.U. Citta della Salute e della Scienza di Torino/Hematology
Torino, Italy
Status: Not yet recruiting
Contact: Antonio Palumbo - +390116996107 - antonio.palumbo@yahoo.com
Start Date
November 2013
Sponsors
Acetylon Pharmaceuticals Incorporated
Source
Acetylon Pharmaceuticals Incorporated
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page