Circulating Fibrocytes in Non-small Cell Lung Cancer.
Conditions
NSCLC
Conditions: Keywords
circulating fibrocytes, fibrocyte, NSCLC, treatment response, survival, stage
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Overall Status
Recruiting
Summary
The investigators will collect fibrocytes (CD45+Col-1+) in patients with non-small cell lung cancer (NSCLC). The investigators hypothesize that patients with NSCLC experience expansion of immunosuppressive fibrocytes, which are predicted to augment tumor growth by mediating immune escape in NSCLC patients.
Detailed Description
Fibrocytes have been described in both mice and humans, where they bear a hematopoietic progenitor phenotype (CD45+Col-1+). Fibrocytes have previously been described in murine cancer, implicated as mediators of tumor immune escape. In this study, the investigators will collect fibrocytes including CD45+Col-1+ expression. The cells express indoleamine oxidase, which is primarily responsible for their immunosuppressive properties. The investigators hypothesize that patients with non-small cell lung cancer experience expansion of immunosuppressive fibrocytes, which are predicted to augment tumor growth by mediating immune escape in non-small cell lung cancer patients.
Criteria for eligibility
Healthy Volunteers: Accepts Healthy Volunteers
Maximum Age: N/A
Minimum Age: 20 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC).

Exclusion Criteria:

- Combination of other malignancy.

- Age less than 20 years (not include 20 years).

- Pregnancy.
Locations
Chang Gung Memorial Hospital
Linkou, Taiwan
Status: Recruiting
Contact: Fu-Tsai Chung - vikingchung@yahoo.com.tw
Chang Gung Memoral Hospital
Taoyuan, Taiwan
Status: Recruiting
Contact: Fu-Tsai Chung - vikingchung@yahoo.com.tw
Start Date
November 2013
Completion Date
May 2015
Sponsors
Chang Gung Memorial Hospital
Source
Chang Gung Memorial Hospital
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page