Window of Opportunity Study of VS-6063 (Defactinib) in Participants With Surgical Resectable Malignant Pleural Mesothelioma.
Conditions
Malignant Pleural Mesothelioma
Conditions: official terms
Mesothelioma
Conditions: Keywords
Mesothelioma, adenoma, Neoplasms, Mesothelial, Focal Adhesion Kinase Inhibitor
Study Type
Interventional
Study Phase
Phase 2
Study Design
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: VS-6063
Type: Drug
Overall Status
Recruiting
Summary
This is an open label neoadjuvant (treatment with VS-6063 prior to mesothelioma surgery) study in subjects with malignant pleural mesothelioma who are eligible for surgery. Subjects will receive VS-6063 (defactinib) for 12 days. Pre- and post-treatment biopsies and blood samples will be collected. The purpose of this study is to assess biomarker responses from tumor tissue. The safety, pharmacokinetics, and tumor response rate to VS-6063 (defactinib) will be also be assessed.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Histologically confirmed malignant pleural mesothelioma that is not metastatic or unresectable

- Eligible to undergo excisional surgery such as extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/DC) or any other mesothelioma surgery.

- Localized disease. The malignancy is confined to one affected hemithorax. Mediastinal N2 lymph nodes via cervical mediastinoscopy or EBUS (endobronchial ultrasound) must be negative in order to be eligible

- Grossly normal pulmonary, cardiac function, renal, hepatic hematologic and performance functions

- Male or non-pregnant female

- Age ≥ 18 years of age

- Tissue is required prior to enrollment. If patient was diagnosed outside and tumor tissue is not available, a pleural biopsy for frozen tissue collection is required.

Exclusion Criteria:

- Participants who have had chemotherapy or radiotherapy any time prior to entering the study or at any prior time for mesothelioma. Patients receiving chemotherapy type drugs for benign conditions can participate in this trial

- History of upper gastrointestinal bleeding, ulceration, or perforation within 12 months prior to the first dose of study drug

- Known history of Gilbert's Syndrome or any current hyperbilirubinemia of any cause

- Known history of stroke or cerebrovascular accident within 6 months prior to the first dose of study drug

- Subjects with known infection with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS)

- Subjects with confirmed Hepatitis A, B or C

- Subjects being actively treated for a secondary malignancy or any malignancy within the last 5 years, with the exception of non-melanomatous skin cancer or localized, definitively treated cervical cancer

- Uncontrolled or severe cardiovascular disease, including myocardial infarct or unstable angina within 6 months prior to study treatment, New York Heart Association (NYHA) Class II or greater congestive heart failure, serious arrhythmias requiring medication for treatment, clinically significant pericardial disease, or cardiac amyloidosis

- Known history of malignant hypertension

- Uncontrolled intercurrent illness including symptomatic congestive heart failure, cardiac arrhythmia, or psychiatric illness/social situations which in the opinion of the study investigators would be associated with undue risk of participation in the study
Location
Brigham and Women's Hospital
Boston, Massachusetts, United States
Status: Recruiting
Contact: Julianne Barlow - 617-525-8541 - jbarlow1@partners.org
Start Date
December 2013
Completion Date
November 2015
Sponsors
Verastem, Inc.
Source
Verastem, Inc.
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page