Thin Prep Versus Traditional Cytological Procedure for Lung Cancer
Conditions
Lung Cancer
Conditions: official terms
Lung Neoplasms
Conditions: Keywords
Lung Cancer, Bronchoscopy, Fine Need Aspiration, Cytochemical Assays
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Overall Status
Recruiting
Summary
In the diagnosis of lung cancer, the cytological sample obtained during Bronchoscopy (FBS), has an increasingly important role in the characterization of malignancy. The cytological sample can be harvested during bronchoscopy by bronchial brushing, bronchial lavages or fine needle aspiration. Immunocytochemical staining allows not only to discriminate between small cell lung cancer versus non-small cell lung cancer (NSCLC), but also to identify the expression of specific markers such as TTF-1, CK7, CK20, 4A4, 34βE12 and p63. Thin Prep is a technique for cytological assay already validated and largely used in the immunocytochemical determination of gynaecologic specimens. Further Studies are required to asses the accuracy of this technique compared to conventional smear in cytological airway samples obtained by fine needle aspiration.
Detailed Description
Patients undergoing FBS for lung cancer diagnosis purpose will be enrolled in the study. During FBS Fine Need Aspiration (FNA) will be performed. Four samplings by FNA will be performed in each patient. Two samplings will be processed with thin prep technique and two samplings with the traditional procedure. To avoid sampling procedures-related bias, the first harvested sample will be randomly tested with Thin Prep or Traditional technique.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 84 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- FBS undergoing bronchoscopy for diagnostic purpose of lung cancer.

- Informed consent.

- ASA Classification 1-3.

Exclusion Criteria:

- Patients intubated.

- Patients with respiratory failure.
Location
Bronchoscopy Unit, Section of Repiratory Disease, azienda ospedaliera universitaria di Ferrara
Ferrara, Italy
Status: Recruiting
Contact: Alberto Papi, MD - +390532236908 - ppa@unife.it
Start Date
May 2013
Completion Date
May 2014
Sponsors
Università degli Studi di Ferrara
Source
Università degli Studi di Ferrara
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page