Prognostic Relevance of Biological Subtype in Breast Cancer
Breast Cancer
Conditions: official terms
Breast Neoplasms
Study Type
Study Phase
Study Design
Time Perspective: Retrospective
Overall Status
Recently, the investigators face "on the edges" for treatment decision to decide adjuvant systemic treatment, especially for patients who show discordance between stage and tumor biology. The aim of this study was to compare the prognostic relevance of the TNM staging system and intrinsic subtype in breast cancer patients who received curative surgery.
Detailed Description
Identified patients who received curative surgery for stage I-III breast cancer and had available data on immunohistochemistry profiles including hormone receptor status (HR) status, human epidermal growth factor receptor 2 (HER2) status, and Ki 67 staining at Samsung Medical Center from January 2004 to September 2008. Primary outcomes were recurrence-free survival (RFS) and overall survival (OS).
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Female
Criteria: Inclusion Criteria:

- patients who received curative surgery

- stage I-III breast cancer

- between January 2004 and September 2008

- had available immunohistochemistry profiles.

exclusion Criteria:

- age <18 years old

- microinvasive carcinoma of breast
Samsung Medical Center, Sungkyunkwan University School of Medicine
Seoul, Korea, Republic of
Status: Recruiting
Contact: Young-Hyuck Im, MD, PhD - +82-2-3410-3445 -
Start Date
February 2014
Completion Date
May 2014
Samsung Medical Center
Samsung Medical Center
Record processing date processed this data on July 28, 2015 page