Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection
Conditions
Breast Cancer
Conditions: Keywords
total intravenous anesthesia, inhalation anesthesia, cancer cell cytotoxicity, breast tumor
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
Intervention
Name: intravenous anesthesia Type: Procedure
Name: inhalation anesthesia Type: Procedure
Name: propofol-remifentanil Type: Drug
Name: sevoflurane-remifentanil Type: Drug
Overall Status
Recruiting
Summary
The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 65 Years
Minimum Age: 20 Years
Gender: Female
Criteria: Inclusion Criteria:

- patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ

- breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies

- surgery performed by the same surgical team

Exclusion Criteria:

- ASA physical status Ⅳ

- hepatic and renal impairment

- diabetes or other endocrine disorders

- body mass index > 35 kg/m2

- immune disorders or immunosuppressive therapy

- steroid treatment in the last 6 months

- inflammation
Location
Severance Hospital
Seoul, Korea, Republic of
Status: Recruiting
Contact: Bon Nyeo Koo, MD - 82-2-2228-2420 - koobn@yuhs.ac
Start Date
February 2014
Completion Date
February 2015
Sponsors
Yonsei University
Source
Yonsei University
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
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