Observational Study of Biomarker During Liver Surgery
Conditions
Liver Cancer - Hepatobiliary Tract Adenomas and Carcinomas
Conditions: Keywords
liver, ischemia, reperfusion
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Intervention
Name: Hepatocellular carcinoma
Type: Procedure
Overall Status
Recruiting
Summary
The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.
Detailed Description
If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 70 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- liver resection > 2 segments,

- plate count > 100 x 109/L, and

- prothrombin activity >60%.

Exclusion Criteria:

- liver cirrhosis,

- portal hypertension,

- steatohepatitis or severe steatosis,

- patients receiving additional ablation therapies,

- laparoscopic resection, and

- simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy
Location
UF Health
Gainesville, Florida, United States
Status: Recruiting
Contact: Jae-Sung Kim, PhD - 352-392-7461 - jae.kim@surgery.ufl.edu
Start Date
October 2014
Completion Date
December 2019
Sponsors
University of Florida
Source
University of Florida
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page