Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy
Liver Neoplasms
Conditions: official terms
Ischemia - Liver Neoplasms
Conditions: Keywords
hepatic ischemia reperfusion injury, ischemia precondition, remote ischemia precondition, anti-inflammation
Study Type
Study Phase
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care
Name: Remote ischemia precondition Type: Other
Name: None remote ischemia precondition Type: Other
Overall Status
Not yet recruiting
Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.
Detailed Description
Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 70 Years
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade

- Selective hepatectomy, one time hepatic portal occlusion

- Child-Pugh A

Exclusion Criteria:

- Peripheral vessels diseases

- Not the same surgical procedure as expected

- Administered anti-inflammatory drugs as glucocorticoid etc

- Diagnosed of diabetes

- History of liver surgery

- History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy

- Refuse to join the research

- Patients with psychopathy

- Acute infection need antibiotic therapy

- Hepatic artery or portal vein embolism
Eastern Hepatobiliary Surgery Hospital
Shanghai, Shanghai, China
Status: Not yet recruiting
Contact: Weifeng Yu, professor - 86-10-81875231 -
Start Date
September 2014
Completion Date
June 2016
Eastern Hepatobiliary Surgery Hospital
Eastern Hepatobiliary Surgery Hospital
Record processing date processed this data on July 28, 2015 page