The Association Between Areca-nut Chewing Habit and Metabolic Syndrome
Conditions
Oral and Esophageal Cancer - Metabolic Syndrome.
Conditions: official terms
Esophageal Neoplasms - Metabolic Syndrome X
Conditions: Keywords
nut chewing
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Overall Status
Recruiting
Summary
The purpose of this study is going to determine the odds ratio of metabolic syndrome (MS), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients. The current study was designed as a case-control study. Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing are defined as case group. Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing are defined as control group. The participants' age, blood pressures, and smoking habits will be recorded. Body weight, height, waist, and hip circumferences will be measured. Fasting venous blood samples will be obtained to determine hematological parameters [i.e., serum creatinine, total cholesterol, triacylglycerol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, and inflammatory markers (C-reactive protein, tumor necrosis factor-alpha, and interleukin-6)]. Logistic regression analyses are going to perform to examine the relationship between areca nut chewing and MS in this population. If we can make sure the relationship between areca nut chewing and MS, the clinicians and nutritionists can teach people to quit areca nut chewing in order to avoid the possibility of developing metabolic syndrome and cardiovascular disease.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: 80 Years
Minimum Age: 20 Years
Gender: Both
Criteria: Inclusion Criteria:

- Patients proved to be oral and esophageal cancer will be recruited.

Exclusion Criteria:

- Subjects with diabetes mellitus, liver, renal diseases, or undergoing statin therapy.

- Taking antioxidant vitamins supplements.
Location
Taichung Verterans General Hospital
Taichung, Taiwan
Status: Recruiting
Contact: Ping-Ting Lin, Ph.D. - +886-24730022 - apt810@csmu.edu.tw
Start Date
April 2014
Sponsors
Taichung Veterans General Hospital
Source
Taichung Veterans General Hospital
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page