Improving Clinical Staging for Muscle Invasive Bladder Cancer Through Molecular Profiling and Improved Imaging
Conditions
Bladder Cancer
Conditions: official terms
Urinary Bladder Neoplasms
Conditions: Keywords
Bladder cancer, Muscle invasive bladder cancer, MIBC, Biopsy specimen molecular profiling, Bladder surgery, Magnetic resonance imaging, MRI, Trans urethral resection of bladder
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Intervention
Name: Tissue Biopsy Type: Procedure
Name: Magnetic Resonance Imaging (MRI) Type: Procedure
Overall Status
Recruiting
Summary
The goal of this research study is to improve detection of cancer outside of the bladder through genetic testing and improved imaging.
Detailed Description
If you agree to take part in the study, a piece of the tumor that is removed during the biopsy will be collected for research purposes. The tissue will be sent to the laboratory for genetic testing.

If you have had a computed tomography scan (CT scan) or magnetic resonance imaging scan (MRI) recently, information collected from the scan will be collected. If you have not had one recently, you will have an MRI with contrast as part of this study. You will receive a separate consent form for this MRI scan.

The results of the test will be given to your doctor, but the results will not be used to decide your treatment.

After you have surgery, information will be collected from your medical records, such as your diagnosis.

Length of Study:

Your participation on this study will be over once your surgery is completed.

This is an investigational study.

Up to 100 participants will take part in this study. All will be enrolled at MD Anderson.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: N/A
Gender: Both
Criteria: Inclusion Criteria:

1. Patients with biopsy proven bladder cancer of any age will be eligible for enrollment.

Exclusion Criteria:

1. Contraindication to pelvic MRI (metallic implants/hardware, claustrophobia)

2. Participants who have previously received chemotherapy as part of multimodal therapy.
Location
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Status: Recruiting
Start Date
June 2014
Sponsors
M.D. Anderson Cancer Center
Source
M.D. Anderson Cancer Center
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page