Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy
Conditions
Prostate Cancer - Urinary Tract Infection - Clostridium Difficile
Conditions: official terms
Urinary Tract Infections
Study Type
Interventional
Study Phase
N/A
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention
Name: Ciprofloxacin
Type: Drug
Overall Status
Recruiting
Summary
The aim of this study is to determine whether antibiotics prophylaxis at the time of urinary catheter removal decreases the number of symptomatic urinary tract infections in patients after radical prostatectomy. In addition, the investigators aim to determine whether antibiotic prophylaxis is potentially harmful to patients (e.g. adverse reactions from antibiotic use, resistant bacteria in the urine, Clostridium difficile infections etc.). The investigators also aim to identify specific populations that may be at higher risk of developing urinary tract infections with urinary catheter use after radical prostatectomy.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Male
Criteria: Inclusion Criteria:

- Subjects will include patients undergoing radical prostatectomy for prostate cancer. Subjects will be randomized into control or treatment group.

Exclusion Criteria:

- Subjects with a history of adverse reaction to ciprofloxacin, or any other quinolone will be excluded. Subjects being treated with tizanidine or with a history of myasthenia gravis will be excluded. In addition, we will exclude patients with major immediate post-operative complications after prostatectomy including significant post-operative bleeding with known pelvic hematoma and known urine leak.
Location
University of Rochester Medical Center
Rochester, New York, United States
Status: Recruiting
Contact: Jean V Joseph, M.D. - jean_joseph@urmc.rochester.edu
Start Date
July 2014
Sponsors
University of Rochester
Source
University of Rochester
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page