Molecular Signatures of Relapse in Tissue Samples From Patients With Small Cell Lung Cancer Who Are Receiving Cisplatin and Etoposide
Small Cell Lung Cancer
Conditions: official terms
Lung Neoplasms - Small Cell Lung Carcinoma
Study Type
Study Phase
Study Design
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Name: cytology specimen collection procedure Type: Other
Name: laboratory biomarker analysis Type: Other
Overall Status
This pilot research trial studies molecular signatures of the return of cancer after a period of improvement (relapse) in tissue samples from patients with small cell lung cancer who are receiving or planning to receive cisplatin and etoposide. Studying samples of tissue from patients with small cell lung cancer in the laboratory may help doctors learn more about the changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer relapse.
Detailed Description

I. To collect and analyze small cell lung cancer (SCLC) tumor DNA and ribonucleic acid (RNA) from 3 human patients before and after relapse to identify the molecular signatures of relapse.


Previously collected tissue samples are analyzed via RNA sequencing and DNA methylation at baseline. Patients also undergo collection of tissue samples for analysis at relapse.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Any patient seen at Norris or County with histologically confirmed SCLC, with tissue in the Norris Cancer Center Tumor Repository

- Patients must be undergoing or about to start first line treatment with cisplatin and etoposide

- Patients may not have a second malignancy
Los Angeles County-USC Medical Center
Los Angeles, California, United States
Status: Recruiting
Contact: Barbara J. Gitlitz - 323-865-3000 -
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States
Status: Recruiting
Contact: Gina Tse, R.N. - 323-865-0514 -
Start Date
August 2014
Completion Date
February 2016
University of Southern California
University of Southern California
Record processing date processed this data on July 28, 2015 page