Molecular Signatures of Relapse in Tissue Samples From Patients With Small Cell Lung Cancer Who Are Receiving Cisplatin and Etoposide
Conditions
Small Cell Lung Cancer
Conditions: official terms
Lung Neoplasms - Small Cell Lung Carcinoma
Study Type
Observational
Study Phase
N/A
Study Design
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Intervention
Name: cytology specimen collection procedure Type: Other
Name: laboratory biomarker analysis Type: Other
Overall Status
Recruiting
Summary
This pilot research trial studies molecular signatures of the return of cancer after a period of improvement (relapse) in tissue samples from patients with small cell lung cancer who are receiving or planning to receive cisplatin and etoposide. Studying samples of tissue from patients with small cell lung cancer in the laboratory may help doctors learn more about the changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer relapse.
Detailed Description
PRIMARY OBJECTIVES:

I. To collect and analyze small cell lung cancer (SCLC) tumor DNA and ribonucleic acid (RNA) from 3 human patients before and after relapse to identify the molecular signatures of relapse.

OUTLINE:

Previously collected tissue samples are analyzed via RNA sequencing and DNA methylation at baseline. Patients also undergo collection of tissue samples for analysis at relapse.
Criteria for eligibility
Healthy Volunteers: No
Maximum Age: N/A
Minimum Age: 18 Years
Gender: Both
Criteria: Inclusion Criteria:

- Any patient seen at Norris or County with histologically confirmed SCLC, with tissue in the Norris Cancer Center Tumor Repository

- Patients must be undergoing or about to start first line treatment with cisplatin and etoposide

- Patients may not have a second malignancy
Locations
Los Angeles County-USC Medical Center
Los Angeles, California, United States
Status: Recruiting
Contact: Barbara J. Gitlitz - 323-865-3000 - gitlitz@usc.edu
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States
Status: Recruiting
Contact: Gina Tse, R.N. - 323-865-0514 - Gina.Tse@med.usc.edu
Start Date
August 2014
Completion Date
February 2016
Sponsors
University of Southern California
Source
University of Southern California
Record processing date
ClinicalTrials.gov processed this data on July 28, 2015
ClinicalTrials.gov page